COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study

Background. Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) strategy during the pandemic. This study investigated the ass...

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Autores: Goffin, E, Candellier, A, Vart, P, Noordzij, M, Arnol, M, Covic, A, Lentini, P, Malik, S, Reichert, LJ, Sever, MS, Watschinger, B, Jager, KJ, Gansevoort, RT, Canal C., Facundo C., ERACODA Collaborators
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p11812
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11812
https://pure.eur.nl/ws/files/73363236/COVID_19_related_mortality_in_kidney_transplant_and_haemodialysis_patients.pdf
Access Level:acceso abierto
Palabra clave:COVID-19
dialysis
kidney
mortality
transplantation
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spelling COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based studyGoffin, ECandellier, AVart, PNoordzij, MArnol, MCovic, ALentini, PMalik, SReichert, LJSever, MSWatschinger, BJager, KJGansevoort, RTCanal C.Facundo C.ERACODA CollaboratorsCOVID-19dialysiskidneymortalitytransplantationBackground. Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) strategy during the pandemic. This study investigated the association of the type of KRT with COVID-19 severity, adjusting for differences in individual characteristics. Methods. Data on KT recipients and HD patients diagnosed with COVID-19 between 1 February 2020 and 1 December 2020 were retrieved from the European Renal Association COVID-19 Database. Cox regression models adjusted for age, sex, frailty and comorbidities were used to estimate hazard ratios (HRs) for 28-day mortality risk in all patients and in the subsets that were tested because of symptoms. Results. A total of 1670 patients (496 functional KT and 1174 HD) were included; 16.9% of KT and 23.9% of HD patients died within 28 days of presentation. The unadjusted 28-day mortality risk was 33% lower in KT recipients compared with HD patients {HR 0.67 [95% confidence interval (CI) 0.52-0.85]}. In a fully adjusted model, the risk was 78% higher in KT recipients [HR 1.78 (95% CI 1.22-2.61)] compared with HD patients. This association was similar in patients tested because of symptoms [fully adjusted model HR 2.00 (95% CI 1.31-3.06)]. This risk was dramatically increased during the first post-transplant year. Results were similar for other endpoints (e.g. hospitalization, intensive care unit admission and mortality >28 days) and across subgroups. Conclusions. KT recipients had a greater risk of a more severe course of COVID-19 compared with HD patients, therefore they require specific infection mitigation strategies.OXFORD UNIV PRESS2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11812https://pure.eur.nl/ws/files/73363236/COVID_19_related_mortality_in_kidney_transplant_and_haemodialysis_patients.pdfNEPHROLOGY DIALYSIS TRANSPLANTATIONISSN: 09310509ISSNe: 14602385reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p118122026-06-14T12:41:47Z
dc.title.none.fl_str_mv COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
title COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
spellingShingle COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
Goffin, E
COVID-19
dialysis
kidney
mortality
transplantation
title_short COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
title_full COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
title_fullStr COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
title_full_unstemmed COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
title_sort COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
dc.creator.none.fl_str_mv Goffin, E
Candellier, A
Vart, P
Noordzij, M
Arnol, M
Covic, A
Lentini, P
Malik, S
Reichert, LJ
Sever, MS
Watschinger, B
Jager, KJ
Gansevoort, RT
Canal C.
Facundo C.
ERACODA Collaborators
author Goffin, E
author_facet Goffin, E
Candellier, A
Vart, P
Noordzij, M
Arnol, M
Covic, A
Lentini, P
Malik, S
Reichert, LJ
Sever, MS
Watschinger, B
Jager, KJ
Gansevoort, RT
Canal C.
Facundo C.
ERACODA Collaborators
author_role author
author2 Candellier, A
Vart, P
Noordzij, M
Arnol, M
Covic, A
Lentini, P
Malik, S
Reichert, LJ
Sever, MS
Watschinger, B
Jager, KJ
Gansevoort, RT
Canal C.
Facundo C.
ERACODA Collaborators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
dialysis
kidney
mortality
transplantation
topic COVID-19
dialysis
kidney
mortality
transplantation
description Background. Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) strategy during the pandemic. This study investigated the association of the type of KRT with COVID-19 severity, adjusting for differences in individual characteristics. Methods. Data on KT recipients and HD patients diagnosed with COVID-19 between 1 February 2020 and 1 December 2020 were retrieved from the European Renal Association COVID-19 Database. Cox regression models adjusted for age, sex, frailty and comorbidities were used to estimate hazard ratios (HRs) for 28-day mortality risk in all patients and in the subsets that were tested because of symptoms. Results. A total of 1670 patients (496 functional KT and 1174 HD) were included; 16.9% of KT and 23.9% of HD patients died within 28 days of presentation. The unadjusted 28-day mortality risk was 33% lower in KT recipients compared with HD patients {HR 0.67 [95% confidence interval (CI) 0.52-0.85]}. In a fully adjusted model, the risk was 78% higher in KT recipients [HR 1.78 (95% CI 1.22-2.61)] compared with HD patients. This association was similar in patients tested because of symptoms [fully adjusted model HR 2.00 (95% CI 1.31-3.06)]. This risk was dramatically increased during the first post-transplant year. Results were similar for other endpoints (e.g. hospitalization, intensive care unit admission and mortality >28 days) and across subgroups. Conclusions. KT recipients had a greater risk of a more severe course of COVID-19 compared with HD patients, therefore they require specific infection mitigation strategies.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11812
https://pure.eur.nl/ws/files/73363236/COVID_19_related_mortality_in_kidney_transplant_and_haemodialysis_patients.pdf
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11812
https://pure.eur.nl/ws/files/73363236/COVID_19_related_mortality_in_kidney_transplant_and_haemodialysis_patients.pdf
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv NEPHROLOGY DIALYSIS TRANSPLANTATION
ISSN: 09310509
ISSNe: 14602385
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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