Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation
Biodiversity loss is one major outcome of human-mediated ecosystem disturbance. One way that humans have triggered wildlife declines is by transporting disease-causing agents to remote areas of the world. Amphibians have been hit particularly hard by disease due in part to a globally distributed pat...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/224491 |
| Acesso em linha: | http://hdl.handle.net/10261/224491 |
| Access Level: | acceso abierto |
| Palavra-chave: | Batrachochytrium dendrobatidis Amphibians Conservation Genetic monitoring |
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Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservationByrne, Allison Q.Vredenburg, Vance T.Martel, AnPasmans, FrankBell, Rayna C.Blackburn, David C.Bletz, Molly C.Bosch, JaimeBriggs, Cheryl J.Brown, Rafe M.Catenazzi, AlessandroFamiliar López, MarielFigueroa-Valenzuela, RaúlGhose, Sonia L.Jaeger, Jef R.Jani, Andrea J.Jirku, MiloslavKnapp, Roland A.Muñoz, AntonioPortik, Daniel M.Richards-Zawacki, Corine L.Rockney, HeidiRovito, Sean M.Sulaeman, HasanTao, Nguyen ThienVoyles, JamieWaddle, Anthony W.Yuan, ZhiyongRosenblum, Erica BreeBatrachochytriumdendrobatidisAmphibiansConservationGenetic monitoringBiodiversity loss is one major outcome of human-mediated ecosystem disturbance. One way that humans have triggered wildlife declines is by transporting disease-causing agents to remote areas of the world. Amphibians have been hit particularly hard by disease due in part to a globally distributed pathogenic chytrid fungus (Batrachochytrium dendrobatidis [Bd]). Prior research has revealed important insights into the biology and distribution of Bd; however, there are still many outstanding questions in this system. Although we know that there are multiple divergent lineages of Bd that differ in pathogenicity, we know little about how these lineages are distributed around the world and where lineages may be coming into contact. Here, we implement a custom genotyping method for a global set of Bd samples. This method is optimized to amplify and sequence degraded DNA from noninvasive skin swab samples. We describe a divergent lineage of Bd, which we call BdASIA3, that appears to be widespread in Southeast Asia. This lineage co-occurs with the global panzootic lineage (BdGPL) in multiple localities. Additionally, we shed light on the global distribution of BdGPL and highlight the expanded range of another lineage, BdCAPE. Finally,we argue that more monitoring needs to take place where Bd lineages are coming into contact and where we know little about Bd lineage diversity. Monitoring need not use expensive or difficult field techniques but can use archived swab samples to further explore the history—and predict the future impacts—of this devastating pathogen.This work was supported by NSF Grant IOS 1354241 (to E.B.R.), NSF Grant DEB 1557190 (to C.J.B., R.A.K., and E.B.R.), NSF Grant DEB 1551488 (to J.V., C.L.R.-Z., and E.B.R.), and the NSF Graduate Research Fellowship Program (A.Q.B.). Sequencing done at the University of Idaho Institute of Bioinformatics and Evolutionary Studies Genomics Resources Core is supported by NIH Centers of Biomedical Research Excellence Phase III Grant P30GM103324. Sample collection was supported by grants from the NSF (DEB-1202609 [to D.C.B.]; DEB-0743491, 0334952, 1418895, and 1654388 [to R.M.B.]; and Belmont Forum 1633948 [to V.T.V.]), the Czech Science Foundation and Institute of Parasitology (Grants P506/10/2330 and RVO 60077344 [to M.J.]), the National Natural Science Foundation of China (Grant 31702008 [to Z.Y.]), and the Yunnan Applied Basic Research Project (Grant 2018FD047 [to Z.Y.]).National Academy of Sciences (U.S.)National Science Foundation (US)Czech Science FoundationNational Natural Science Foundation of ChinaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/224491reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1073/pnas.1908289116Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2244912026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation |
| title |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation |
| spellingShingle |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation Byrne, Allison Q. Batrachochytrium dendrobatidis Amphibians Conservation Genetic monitoring |
| title_short |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation |
| title_full |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation |
| title_fullStr |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation |
| title_full_unstemmed |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation |
| title_sort |
Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation |
| dc.creator.none.fl_str_mv |
Byrne, Allison Q. Vredenburg, Vance T. Martel, An Pasmans, Frank Bell, Rayna C. Blackburn, David C. Bletz, Molly C. Bosch, Jaime Briggs, Cheryl J. Brown, Rafe M. Catenazzi, Alessandro Familiar López, Mariel Figueroa-Valenzuela, Raúl Ghose, Sonia L. Jaeger, Jef R. Jani, Andrea J. Jirku, Miloslav Knapp, Roland A. Muñoz, Antonio Portik, Daniel M. Richards-Zawacki, Corine L. Rockney, Heidi Rovito, Sean M. Sulaeman, Hasan Tao, Nguyen Thien Voyles, Jamie Waddle, Anthony W. Yuan, Zhiyong Rosenblum, Erica Bree |
| author |
Byrne, Allison Q. |
| author_facet |
Byrne, Allison Q. Vredenburg, Vance T. Martel, An Pasmans, Frank Bell, Rayna C. Blackburn, David C. Bletz, Molly C. Bosch, Jaime Briggs, Cheryl J. Brown, Rafe M. Catenazzi, Alessandro Familiar López, Mariel Figueroa-Valenzuela, Raúl Ghose, Sonia L. Jaeger, Jef R. Jani, Andrea J. Jirku, Miloslav Knapp, Roland A. Muñoz, Antonio Portik, Daniel M. Richards-Zawacki, Corine L. Rockney, Heidi Rovito, Sean M. Sulaeman, Hasan Tao, Nguyen Thien Voyles, Jamie Waddle, Anthony W. Yuan, Zhiyong Rosenblum, Erica Bree |
| author_role |
author |
| author2 |
Vredenburg, Vance T. Martel, An Pasmans, Frank Bell, Rayna C. Blackburn, David C. Bletz, Molly C. Bosch, Jaime Briggs, Cheryl J. Brown, Rafe M. Catenazzi, Alessandro Familiar López, Mariel Figueroa-Valenzuela, Raúl Ghose, Sonia L. Jaeger, Jef R. Jani, Andrea J. Jirku, Miloslav Knapp, Roland A. Muñoz, Antonio Portik, Daniel M. Richards-Zawacki, Corine L. Rockney, Heidi Rovito, Sean M. Sulaeman, Hasan Tao, Nguyen Thien Voyles, Jamie Waddle, Anthony W. Yuan, Zhiyong Rosenblum, Erica Bree |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
National Science Foundation (US) Czech Science Foundation National Natural Science Foundation of China Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Batrachochytrium dendrobatidis Amphibians Conservation Genetic monitoring |
| topic |
Batrachochytrium dendrobatidis Amphibians Conservation Genetic monitoring |
| description |
Biodiversity loss is one major outcome of human-mediated ecosystem disturbance. One way that humans have triggered wildlife declines is by transporting disease-causing agents to remote areas of the world. Amphibians have been hit particularly hard by disease due in part to a globally distributed pathogenic chytrid fungus (Batrachochytrium dendrobatidis [Bd]). Prior research has revealed important insights into the biology and distribution of Bd; however, there are still many outstanding questions in this system. Although we know that there are multiple divergent lineages of Bd that differ in pathogenicity, we know little about how these lineages are distributed around the world and where lineages may be coming into contact. Here, we implement a custom genotyping method for a global set of Bd samples. This method is optimized to amplify and sequence degraded DNA from noninvasive skin swab samples. We describe a divergent lineage of Bd, which we call BdASIA3, that appears to be widespread in Southeast Asia. This lineage co-occurs with the global panzootic lineage (BdGPL) in multiple localities. Additionally, we shed light on the global distribution of BdGPL and highlight the expanded range of another lineage, BdCAPE. Finally,we argue that more monitoring needs to take place where Bd lineages are coming into contact and where we know little about Bd lineage diversity. Monitoring need not use expensive or difficult field techniques but can use archived swab samples to further explore the history—and predict the future impacts—of this devastating pathogen. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2020 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/224491 |
| url |
http://hdl.handle.net/10261/224491 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
http://dx.doi.org/10.1073/pnas.1908289116 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
National Academy of Sciences (U.S.) |
| publisher.none.fl_str_mv |
National Academy of Sciences (U.S.) |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869408112047292416 |
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15,198674 |