Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography

While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and ear...

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Detalles Bibliográficos
Autores: Gonzalez-Tendero, Anna, Zhang, Chong, Balicevic, Vedrana, Cárdenes, Rubén, Loncaric, Sven, Butakoff, Constantine, Paun, Bruno, Bonnin, Anne, Garcia Canadilla, Patricia, Muñoz-Moreno, Emma, Gratacós Solsona, Eduard, Crispi Brillas, Fàtima, Bijnens, Bart
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/36969
Acceso en línea:http://hdl.handle.net/10230/36969
http://dx.doi.org/10.1093/ehjci/jew314
Access Level:acceso abierto
Palabra clave:Myocardial remodelling
Myofibre structure
Coronary vasculature
Synchrotron phase-contrast CT
Descripción
Sumario:While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes is crucial for diagnosis and prevention. Additionally, personalized computational modelling requires knowledge on the multi-scale structure of the whole heart and vessels.

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