Engineering smart nano metal-organic frameworks for biomedical applications

This thesis aims to advance nanomedicine by developing nano metal-organic frameworks for enhanced drug delivery. Various systems were synthesized and tailored to investigate their encapsulation abilities and surface modi ications to provide them with targeting capabilities. Additionally, nanocomposi...

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Detalhes bibliográficos
Autor: Cedrún Morales, Manuela
Formato: tesis doctoral
Fecha de publicación:2024
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/34506
Acesso em linha:http://hdl.handle.net/10347/34506
Access Level:acceso abierto
Palavra-chave:230408 Macromoléculas
Descrição
Resumo:This thesis aims to advance nanomedicine by developing nano metal-organic frameworks for enhanced drug delivery. Various systems were synthesized and tailored to investigate their encapsulation abilities and surface modi ications to provide them with targeting capabilities. Additionally, nanocomposites responsive to near-infrared (NIR) light were created, comprising a core of gold nanoparticles and a shell of nano metal-organic frameworks. These intelligent nanocarriers were designed to facilitate intracellular cargo delivery through innovative strategies.