Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females

Background: Deficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence functionality. Sex differences are observed in individuals with psychosis in mul...

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Autores: Serra Navarro, Maria, Amoretti Guadall, Silvia, Verdolini, Norma, Forte, Maria Florencia, Sánchez-Torres, Ana M., Vieta i Pascual, Eduard, 1963-, Clougher, Derek, Lobo, Antonio, González-Pinto, Ana, Panadero Gómez, Rocío, Roldán, Alexandra, Carvalho, André F., Serna, Elena de la, 1978-, Toll Privat, Alba, Ramos-Quiroga, Josep Antoni, Torrent Font, Carla, Cuesta, Manuel J., Bernardo Arroyo, Miquel, PEPs Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/199926
Acceso en línea:https://hdl.handle.net/2445/199926
Access Level:acceso abierto
Palabra clave:Trastorns de la cognició
Neurociència cognitiva
Conductisme
Diferències entre sexes (Psicologia)
Símptomes
Psicosi
Cognition disorders
Cognitive neuroscience
Behaviorism (Psychology)
Sex differences (Psychology)
Symptoms
Psychoses
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spelling Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and femalesSerra Navarro, MariaAmoretti Guadall, SilviaVerdolini, NormaForte, Maria FlorenciaSánchez-Torres, Ana M.Vieta i Pascual, Eduard, 1963-Clougher, DerekLobo, AntonioGonzález-Pinto, AnaPanadero Gómez, RocíoRoldán, AlexandraCarvalho, André F.Serna, Elena de la, 1978-Toll Privat, AlbaRamos-Quiroga, Josep AntoniTorrent Font, CarlaCuesta, Manuel J.Bernardo Arroyo, MiquelPEPs GroupTrastorns de la cognicióNeurociència cognitivaConductismeDiferències entre sexes (Psicologia)SímptomesPsicosiCognition disordersCognitive neuroscienceBehaviorism (Psychology)Sex differences (Psychology)SymptomsPsychosesBackground: Deficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence functionality. Sex differences are observed in individuals with psychosis in multiple domains. Nonetheless, few studies have explored the predictive factors of poor functioning according to sex in first-episode psychosis (FEP). This study aimed to explore sex differences, examine changes, and identify predictors of functioning according to sex after onset. Materials and methods: The initial sample comprised 588 individuals. However, only adults with non-affective FEP (n = 247, 161 males and 86 females) and healthy controls (n = 224, 142 males and 82 females) were included. A comprehensive assessment including functional, neuropsychological, and clinical scales was performed at baseline and at 2-year follow-up. A linear regression model was used to determine the predictors of functioning at 2-year follow-up. Results: FEP improved their functionality at follow-up (67.4% of both males and females). In males, longer duration of untreated psychosis (β = 0.328, p = 0.003) and worse premorbid adjustment (β = 0.256, p = 0.023) were associated with impaired functioning at 2-year follow-up, while in females processing speed (β = 0.403, p = 0.003), executive function (β = 0.299, p = 0.020) and CR (β = -0.307, p = 0.012) were significantly associated with functioning. Conclusion: Our data indicate that predictors of functioning at 2-year follow-up in the FEP group differ according to sex. Therefore, treatment and preventative efforts may be adjusted taking sex into account. Males may benefit from functional remediation at early stages. Conversely, in females, early interventions centered on CR enhancement and cognitive rehabilitation may be recommended.Frontiers Media2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/199926Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fpsyt.2022.982583Frontiers In Psychiatry, 2022, vol. 13, p. 982583https://doi.org/10.3389/fpsyt.2022.982583cc-by (c) Serra Navarro, Maria et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1999262026-05-27T06:46:51Z
dc.title.none.fl_str_mv Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
title Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
spellingShingle Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
Serra Navarro, Maria
Trastorns de la cognició
Neurociència cognitiva
Conductisme
Diferències entre sexes (Psicologia)
Símptomes
Psicosi
Cognition disorders
Cognitive neuroscience
Behaviorism (Psychology)
Sex differences (Psychology)
Symptoms
Psychoses
title_short Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
title_full Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
title_fullStr Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
title_full_unstemmed Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
title_sort Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
dc.creator.none.fl_str_mv Serra Navarro, Maria
Amoretti Guadall, Silvia
Verdolini, Norma
Forte, Maria Florencia
Sánchez-Torres, Ana M.
Vieta i Pascual, Eduard, 1963-
Clougher, Derek
Lobo, Antonio
González-Pinto, Ana
Panadero Gómez, Rocío
Roldán, Alexandra
Carvalho, André F.
Serna, Elena de la, 1978-
Toll Privat, Alba
Ramos-Quiroga, Josep Antoni
Torrent Font, Carla
Cuesta, Manuel J.
Bernardo Arroyo, Miquel
PEPs Group
author Serra Navarro, Maria
author_facet Serra Navarro, Maria
Amoretti Guadall, Silvia
Verdolini, Norma
Forte, Maria Florencia
Sánchez-Torres, Ana M.
Vieta i Pascual, Eduard, 1963-
Clougher, Derek
Lobo, Antonio
González-Pinto, Ana
Panadero Gómez, Rocío
Roldán, Alexandra
Carvalho, André F.
Serna, Elena de la, 1978-
Toll Privat, Alba
Ramos-Quiroga, Josep Antoni
Torrent Font, Carla
Cuesta, Manuel J.
Bernardo Arroyo, Miquel
PEPs Group
author_role author
author2 Amoretti Guadall, Silvia
Verdolini, Norma
Forte, Maria Florencia
Sánchez-Torres, Ana M.
Vieta i Pascual, Eduard, 1963-
Clougher, Derek
Lobo, Antonio
González-Pinto, Ana
Panadero Gómez, Rocío
Roldán, Alexandra
Carvalho, André F.
Serna, Elena de la, 1978-
Toll Privat, Alba
Ramos-Quiroga, Josep Antoni
Torrent Font, Carla
Cuesta, Manuel J.
Bernardo Arroyo, Miquel
PEPs Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorns de la cognició
Neurociència cognitiva
Conductisme
Diferències entre sexes (Psicologia)
Símptomes
Psicosi
Cognition disorders
Cognitive neuroscience
Behaviorism (Psychology)
Sex differences (Psychology)
Symptoms
Psychoses
topic Trastorns de la cognició
Neurociència cognitiva
Conductisme
Diferències entre sexes (Psicologia)
Símptomes
Psicosi
Cognition disorders
Cognitive neuroscience
Behaviorism (Psychology)
Sex differences (Psychology)
Symptoms
Psychoses
description Background: Deficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence functionality. Sex differences are observed in individuals with psychosis in multiple domains. Nonetheless, few studies have explored the predictive factors of poor functioning according to sex in first-episode psychosis (FEP). This study aimed to explore sex differences, examine changes, and identify predictors of functioning according to sex after onset. Materials and methods: The initial sample comprised 588 individuals. However, only adults with non-affective FEP (n = 247, 161 males and 86 females) and healthy controls (n = 224, 142 males and 82 females) were included. A comprehensive assessment including functional, neuropsychological, and clinical scales was performed at baseline and at 2-year follow-up. A linear regression model was used to determine the predictors of functioning at 2-year follow-up. Results: FEP improved their functionality at follow-up (67.4% of both males and females). In males, longer duration of untreated psychosis (β = 0.328, p = 0.003) and worse premorbid adjustment (β = 0.256, p = 0.023) were associated with impaired functioning at 2-year follow-up, while in females processing speed (β = 0.403, p = 0.003), executive function (β = 0.299, p = 0.020) and CR (β = -0.307, p = 0.012) were significantly associated with functioning. Conclusion: Our data indicate that predictors of functioning at 2-year follow-up in the FEP group differ according to sex. Therefore, treatment and preventative efforts may be adjusted taking sex into account. Males may benefit from functional remediation at early stages. Conversely, in females, early interventions centered on CR enhancement and cognitive rehabilitation may be recommended.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/199926
url https://hdl.handle.net/2445/199926
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fpsyt.2022.982583
Frontiers In Psychiatry, 2022, vol. 13, p. 982583
https://doi.org/10.3389/fpsyt.2022.982583
dc.rights.none.fl_str_mv cc-by (c) Serra Navarro, Maria et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Serra Navarro, Maria et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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