Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation

Chronic use of cannabis leads to both motor deficits and the downregulation of CB1 receptors (CB1R) in the cerebellum. In turn, cerebellar damage is often related to impairments in motor learning and control. Further, a recent motor learning task that measures cerebellar-dependent adaptation has bee...

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Detalles Bibliográficos
Autores: Fernández Amil, Adrián, Rubio Ballester, Belén, Maier, Martina, Verschure, Paul
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/193300
Acceso en línea:https://hdl.handle.net/2445/193300
Access Level:acceso abierto
Palabra clave:Cànnabis
Cerebel
Aprenentatge motor
Trastorns de la cognició
Cannabis
Cerebellum
Motor learning
Cognition disorders
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spelling Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulationFernández Amil, AdriánRubio Ballester, BelénMaier, MartinaVerschure, PaulCànnabisCerebelAprenentatge motorTrastorns de la cognicióCannabisCerebellumMotor learningCognition disordersChronic use of cannabis leads to both motor deficits and the downregulation of CB1 receptors (CB1R) in the cerebellum. In turn, cerebellar damage is often related to impairments in motor learning and control. Further, a recent motor learning task that measures cerebellar-dependent adaptation has been shown to distinguish well between healthy subjects and chronic cannabis users. Thus, the deteriorating effects of chronic cannabis use in motor performance point to cerebellar adaptation as a key process to explain such deficits. We review the literature relating chronic cannabis use, the endocannabinoid system in the cerebellum, and different forms of cerebellar-dependent motor learning, to suggest that CB1R downregulation leads to a generalized underestimation and misprocessing of the sensory errors driving synaptic updates in the cerebellar cortex. Further, we test our hypothesis with a computational model performing a motor adaptation task and reproduce the behavioral effect of decreased implicit adaptation that appears to be a sign of chronic cannabis use. Finally, we discuss the potential of our hypothesis to explain similar phenomena related to motor impairments following chronic alcohol dependency.Elsevier2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/193300Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléshttps://doi.org/10.1016/j.addbeh.2022.107297Addictive Behaviors, 2022, vol.131, num. 107297https://doi.org/10.1016/j.addbeh.2022.107297cc by (c) Fernández Amil, Adrián et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1933002026-05-27T06:46:51Z
dc.title.none.fl_str_mv Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
title Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
spellingShingle Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
Fernández Amil, Adrián
Cànnabis
Cerebel
Aprenentatge motor
Trastorns de la cognició
Cannabis
Cerebellum
Motor learning
Cognition disorders
title_short Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
title_full Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
title_fullStr Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
title_full_unstemmed Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
title_sort Chronic use of cannabis might impair sensory error processing in the cerebellum through endocannabinoid dysregulation
dc.creator.none.fl_str_mv Fernández Amil, Adrián
Rubio Ballester, Belén
Maier, Martina
Verschure, Paul
author Fernández Amil, Adrián
author_facet Fernández Amil, Adrián
Rubio Ballester, Belén
Maier, Martina
Verschure, Paul
author_role author
author2 Rubio Ballester, Belén
Maier, Martina
Verschure, Paul
author2_role author
author
author
dc.subject.none.fl_str_mv Cànnabis
Cerebel
Aprenentatge motor
Trastorns de la cognició
Cannabis
Cerebellum
Motor learning
Cognition disorders
topic Cànnabis
Cerebel
Aprenentatge motor
Trastorns de la cognició
Cannabis
Cerebellum
Motor learning
Cognition disorders
description Chronic use of cannabis leads to both motor deficits and the downregulation of CB1 receptors (CB1R) in the cerebellum. In turn, cerebellar damage is often related to impairments in motor learning and control. Further, a recent motor learning task that measures cerebellar-dependent adaptation has been shown to distinguish well between healthy subjects and chronic cannabis users. Thus, the deteriorating effects of chronic cannabis use in motor performance point to cerebellar adaptation as a key process to explain such deficits. We review the literature relating chronic cannabis use, the endocannabinoid system in the cerebellum, and different forms of cerebellar-dependent motor learning, to suggest that CB1R downregulation leads to a generalized underestimation and misprocessing of the sensory errors driving synaptic updates in the cerebellar cortex. Further, we test our hypothesis with a computational model performing a motor adaptation task and reproduce the behavioral effect of decreased implicit adaptation that appears to be a sign of chronic cannabis use. Finally, we discuss the potential of our hypothesis to explain similar phenomena related to motor impairments following chronic alcohol dependency.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193300
url https://hdl.handle.net/2445/193300
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.addbeh.2022.107297
Addictive Behaviors, 2022, vol.131, num. 107297
https://doi.org/10.1016/j.addbeh.2022.107297
dc.rights.none.fl_str_mv cc by (c) Fernández Amil, Adrián et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Fernández Amil, Adrián et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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