The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) - Incidence and Case-Control Programme

Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and...

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Detalhes bibliográficos
Autores: Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, Haan, Lieuwe de, Selten, Jean Paul, Szöke, Andrei, Llorca, Pierre Michel, Tortelli, Andrea Tortelli, Arango, Celso, Bobes García, Julio, Bernardo Arroyo, Miquel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, Cascia, Caterina La, Barbera, Daniele La, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, EU-GEI WP2 Group, Rutten, Bart P.F., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2020
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/170991
Acesso em linha:https://hdl.handle.net/2445/170991
Access Level:Acceso aberto
Palavra-chave:Esquizofrènia
Psicosi
Schizophrenia
Psychoses
Descrição
Resumo:Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identifed 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial afect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted

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