Early metformin therapy to delay menarche and augment height in girls with precocious pubarche

Objective: To study the effects of early metformin treatment on menarche, height, and polycystic ovary syndrome (PCOS) markers. Low-birthweight (LBW) girls with precocious pubarche (PP) are at risk for an early menarche (< 12 years), an adult stature below target level, and PCOS. Hyperinsulinemic...

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Autores: Ibáñez L, Lopez-Bermejo A, Diaz M, Marcos MV, de Zegher F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p1037
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1037
Access Level:acceso abierto
Palabra clave:Metformin
menarche
insulin
IGF-I
DHEAS
puberty
pubarche
birthweight
epigenetic
androgen excess
polycystic ovary syndrome
PCOS
obesity
height
adrenarche
lipids
abdominal fat
subcutaneous fat
adiposity
hepatic fat
fatty liver
visceral fat
body composition
lean mass
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network_name_str España
repository_id_str
spelling Early metformin therapy to delay menarche and augment height in girls with precocious pubarcheIbáñez LLopez-Bermejo ADiaz MMarcos MVde Zegher FMetforminmenarcheinsulinIGF-IDHEASpubertypubarchebirthweightepigeneticandrogen excesspolycystic ovary syndromePCOSobesityheightadrenarchelipidsabdominal fatsubcutaneous fatadiposityhepatic fatfatty livervisceral fatbody compositionlean massObjective: To study the effects of early metformin treatment on menarche, height, and polycystic ovary syndrome (PCOS) markers. Low-birthweight (LBW) girls with precocious pubarche (PP) are at risk for an early menarche (< 12 years), an adult stature below target level, and PCOS. Hyperinsulinemic insulin resistance is thought to be a key factor. Design: Open-label, randomized study. Setting: University hospital. Patient(s): Thirty-eight LBW-PP girls. Intervention(s): At age 8 years, girls were randomly assigned to remain untreated or to receive metformin for 4 years; subsequently, both subgroups were followed without treatment until each girl was postmenarcheal. Main Outcome Measure(s): Age at menarche, height, weight, endocrine-metabolic state (fasting blood), body composition (by absorptiometry), abdominal fat (subcutaneous vs. visceral), and hepatic adiposity (by magnetic resonance imaging). Result(s): At last assessment, girls in each subgroup were on average 2 years beyond menarche; the mean growth velocity was below 2 cm/years. Age at menarche was 11.4 +/- 0.1 years in untreated girls and 12.5 +/- 0.2 years in metformin-treated girls; the latter girls were taller and much leaner (with less visceral and hepatic fat) and had more favorable levels of circulating insulin, androgens, and lipids. Conclusion(s): Early metformin therapy (age similar to 8-12 years) suffices to delay menarche; to augment postmenarcheal height; to reduce total, visceral, and hepatic adiposity; and to curb the endocrine-metabolic course of LBW-PP girls away from adolescent PCOS. (Fertil Steril(R) 2011;95:727-30. (C) 2011 by American Society for Reproductive Medicine.)ELSEVIER SCIENCE INC2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1037FERTILITY AND STERILITYISSN: 00150282ISSNe: 15565653reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p10372026-05-27T12:37:41Z
dc.title.none.fl_str_mv Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
title Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
spellingShingle Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
Ibáñez L
Metformin
menarche
insulin
IGF-I
DHEAS
puberty
pubarche
birthweight
epigenetic
androgen excess
polycystic ovary syndrome
PCOS
obesity
height
adrenarche
lipids
abdominal fat
subcutaneous fat
adiposity
hepatic fat
fatty liver
visceral fat
body composition
lean mass
title_short Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
title_full Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
title_fullStr Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
title_full_unstemmed Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
title_sort Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
dc.creator.none.fl_str_mv Ibáñez L
Lopez-Bermejo A
Diaz M
Marcos MV
de Zegher F
author Ibáñez L
author_facet Ibáñez L
Lopez-Bermejo A
Diaz M
Marcos MV
de Zegher F
author_role author
author2 Lopez-Bermejo A
Diaz M
Marcos MV
de Zegher F
author2_role author
author
author
author
dc.subject.none.fl_str_mv Metformin
menarche
insulin
IGF-I
DHEAS
puberty
pubarche
birthweight
epigenetic
androgen excess
polycystic ovary syndrome
PCOS
obesity
height
adrenarche
lipids
abdominal fat
subcutaneous fat
adiposity
hepatic fat
fatty liver
visceral fat
body composition
lean mass
topic Metformin
menarche
insulin
IGF-I
DHEAS
puberty
pubarche
birthweight
epigenetic
androgen excess
polycystic ovary syndrome
PCOS
obesity
height
adrenarche
lipids
abdominal fat
subcutaneous fat
adiposity
hepatic fat
fatty liver
visceral fat
body composition
lean mass
description Objective: To study the effects of early metformin treatment on menarche, height, and polycystic ovary syndrome (PCOS) markers. Low-birthweight (LBW) girls with precocious pubarche (PP) are at risk for an early menarche (< 12 years), an adult stature below target level, and PCOS. Hyperinsulinemic insulin resistance is thought to be a key factor. Design: Open-label, randomized study. Setting: University hospital. Patient(s): Thirty-eight LBW-PP girls. Intervention(s): At age 8 years, girls were randomly assigned to remain untreated or to receive metformin for 4 years; subsequently, both subgroups were followed without treatment until each girl was postmenarcheal. Main Outcome Measure(s): Age at menarche, height, weight, endocrine-metabolic state (fasting blood), body composition (by absorptiometry), abdominal fat (subcutaneous vs. visceral), and hepatic adiposity (by magnetic resonance imaging). Result(s): At last assessment, girls in each subgroup were on average 2 years beyond menarche; the mean growth velocity was below 2 cm/years. Age at menarche was 11.4 +/- 0.1 years in untreated girls and 12.5 +/- 0.2 years in metformin-treated girls; the latter girls were taller and much leaner (with less visceral and hepatic fat) and had more favorable levels of circulating insulin, androgens, and lipids. Conclusion(s): Early metformin therapy (age similar to 8-12 years) suffices to delay menarche; to augment postmenarcheal height; to reduce total, visceral, and hepatic adiposity; and to curb the endocrine-metabolic course of LBW-PP girls away from adolescent PCOS. (Fertil Steril(R) 2011;95:727-30. (C) 2011 by American Society for Reproductive Medicine.)
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1037
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1037
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv FERTILITY AND STERILITY
ISSN: 00150282
ISSNe: 15565653
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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