TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.

AIM To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS The coloni...

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Detalhes bibliográficos
Autores: Román González, Elvira, Huertas, Blanca, Prieto, Daniel, Díez Orejas, Rosalía María, Pla Alonso, Jesús
Tipo de documento: artigo
Data de publicação:2018
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/13365
Acesso em linha:https://hdl.handle.net/20.500.14352/13365
Access Level:Acceso aberto
Palavra-chave:579
Candida albicans
Commensalism
Filamentous growth
TUP1
Microbiología (Farmacia)
3302.03 Microbiología Industrial
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oai_identifier_str oai:docta.ucm.es:20.500.14352/13365
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repository_id_str
spelling TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.Román González, ElviraHuertas, BlancaPrieto, DanielDíez Orejas, Rosalía MaríaPla Alonso, Jesús579Candida albicansCommensalismFilamentous growthTUP1Microbiología (Farmacia)3302.03 Microbiología IndustrialAIM To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS The colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. CONCLUSION Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.Future MedicineUniversidad Complutense de Madrid20182018-06-0120182018-06-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/13365reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/133652026-06-02T12:44:21Z
dc.title.none.fl_str_mv TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
title TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
spellingShingle TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
Román González, Elvira
579
Candida albicans
Commensalism
Filamentous growth
TUP1
Microbiología (Farmacia)
3302.03 Microbiología Industrial
title_short TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
title_full TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
title_fullStr TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
title_full_unstemmed TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
title_sort TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
dc.creator.none.fl_str_mv Román González, Elvira
Huertas, Blanca
Prieto, Daniel
Díez Orejas, Rosalía María
Pla Alonso, Jesús
author Román González, Elvira
author_facet Román González, Elvira
Huertas, Blanca
Prieto, Daniel
Díez Orejas, Rosalía María
Pla Alonso, Jesús
author_role author
author2 Huertas, Blanca
Prieto, Daniel
Díez Orejas, Rosalía María
Pla Alonso, Jesús
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579
Candida albicans
Commensalism
Filamentous growth
TUP1
Microbiología (Farmacia)
3302.03 Microbiología Industrial
topic 579
Candida albicans
Commensalism
Filamentous growth
TUP1
Microbiología (Farmacia)
3302.03 Microbiología Industrial
description AIM To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS The colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. CONCLUSION Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-01
2018
2018-06-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/13365
url https://hdl.handle.net/20.500.14352/13365
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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