Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain

Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common geno...

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Autores: Ardanuy Tisaire, María Carmen, Campa, Adela G. de la, García, Ernesto, Fenoll, Asunción, Calatayud, Laura, Cercenado, Emilia, Pérez Trallero, Emilio, Bouza, Emilio, Liñares Louzao, Josefina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/66251
Acceso en línea:https://hdl.handle.net/2445/66251
Access Level:acceso abierto
Palabra clave:Pneumococs
Infeccions per pneumococs
Estreptococs
Resistència als medicaments
Malalties de l'aparell respiratori
Malalties infeccioses
Espanya
Streptococcus pneumonia
Pneumococcal Infections
Streptococcus
Drug resistance
Respiratory organs diseases
Communicable diseases
Spain
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, SpainArdanuy Tisaire, María CarmenCampa, Adela G. de laGarcía, ErnestoFenoll, AsunciónCalatayud, LauraCercenado, EmiliaPérez Trallero, EmilioBouza, EmilioLiñares Louzao, JosefinaPneumococsInfeccions per pneumococsEstreptococsResistència als medicamentsMalalties de l'aparell respiratoriMalalties infecciosesEspanyaStreptococcus pneumoniaPneumococcal InfectionsStreptococcusDrug resistanceRespiratory organs diseasesCommunicable diseasesSpainSince 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.Centers for Disease Control and Prevention2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/66251Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.3201/eid2011.131215Emerging Infectious Diseases, 2014, vol. 20, num. 11, p. 1848-1856http://dx.doi.org/10.3201/eid2011.131215Domini públic / Public domainhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/662512026-05-27T06:46:51Z
dc.title.none.fl_str_mv Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
title Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
spellingShingle Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
Ardanuy Tisaire, María Carmen
Pneumococs
Infeccions per pneumococs
Estreptococs
Resistència als medicaments
Malalties de l'aparell respiratori
Malalties infeccioses
Espanya
Streptococcus pneumonia
Pneumococcal Infections
Streptococcus
Drug resistance
Respiratory organs diseases
Communicable diseases
Spain
title_short Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
title_full Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
title_fullStr Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
title_full_unstemmed Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
title_sort Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
dc.creator.none.fl_str_mv Ardanuy Tisaire, María Carmen
Campa, Adela G. de la
García, Ernesto
Fenoll, Asunción
Calatayud, Laura
Cercenado, Emilia
Pérez Trallero, Emilio
Bouza, Emilio
Liñares Louzao, Josefina
author Ardanuy Tisaire, María Carmen
author_facet Ardanuy Tisaire, María Carmen
Campa, Adela G. de la
García, Ernesto
Fenoll, Asunción
Calatayud, Laura
Cercenado, Emilia
Pérez Trallero, Emilio
Bouza, Emilio
Liñares Louzao, Josefina
author_role author
author2 Campa, Adela G. de la
García, Ernesto
Fenoll, Asunción
Calatayud, Laura
Cercenado, Emilia
Pérez Trallero, Emilio
Bouza, Emilio
Liñares Louzao, Josefina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pneumococs
Infeccions per pneumococs
Estreptococs
Resistència als medicaments
Malalties de l'aparell respiratori
Malalties infeccioses
Espanya
Streptococcus pneumonia
Pneumococcal Infections
Streptococcus
Drug resistance
Respiratory organs diseases
Communicable diseases
Spain
topic Pneumococs
Infeccions per pneumococs
Estreptococs
Resistència als medicaments
Malalties de l'aparell respiratori
Malalties infeccioses
Espanya
Streptococcus pneumonia
Pneumococcal Infections
Streptococcus
Drug resistance
Respiratory organs diseases
Communicable diseases
Spain
description Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/66251
url https://hdl.handle.net/2445/66251
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.3201/eid2011.131215
Emerging Infectious Diseases, 2014, vol. 20, num. 11, p. 1848-1856
http://dx.doi.org/10.3201/eid2011.131215
dc.rights.none.fl_str_mv Domini públic / Public domain
http://creativecommons.org/publicdomain/zero/1.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Domini públic / Public domain
http://creativecommons.org/publicdomain/zero/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centers for Disease Control and Prevention
publisher.none.fl_str_mv Centers for Disease Control and Prevention
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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