The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper
[EN]As cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long-acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA im...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2024 |
| País: | España |
| Recursos: | Universidad de Salamanca (USAL) |
| Repositório: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/168589 |
| Acesso em linha: | http://hdl.handle.net/10366/168589 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Acetylcholine Asthma Bronchodilator Endotype Precision medicine Long-acting muscarinic antagonist Muscarinic Antagonists Anti-Asthmatic Agents Bronchodilator Agents 3207.01 Alergias 3208.08 Mecanismos de Acción de Los Medicamentos 3205.08 Enfermedades Pulmonares asma acetilcolina antiasmáticos broncodilatadores antagonistas muscarínicos |
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The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paperAgache, I.Adcock, I. M.Akdis, C. A.Akdis, M.Bentabol Ramos, G.van den Berge, M.Bocabella, C.Canonica, W. G.Caruso, C.Couto, M.Dávila González, Ignacio JesúsDrummond, D.Fonseca, J.Gherasim, A.del Giacco, S.Jackson, D. J.Jute, M.Licari, A.Loukides, S.Moreira, A.Mukherjee, M.Ojanguren, I.Palomares, O.Papi, A.Pérez del Llano, L.Price, O. J.Rukhazde, M.Shamji, M. H.Shaw, D.Sánchez García, S.Testera Montes, A.Torres, M. J.Eguiluz Gracia, I.AcetylcholineAsthmaBronchodilatorEndotypePrecision medicineLong-acting muscarinic antagonistAsthmaMuscarinic AntagonistsAcetylcholineAnti-Asthmatic AgentsBronchodilator Agents3207.01 Alergias3208.08 Mecanismos de Acción de Los Medicamentos3205.08 Enfermedades Pulmonaresasmaacetilcolinaantiasmáticosbroncodilatadoresantagonistas muscarínicos[EN]As cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long-acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA improve lung function and reduce exacerbations in asthma patients who remained poorly controlled despite treatment with inhaled corticosteroids and long-acting β2 agonists. Asthma guidelines recommend LAMA as a third controller to be added on before the initiation of biologicals. In addition to bronchodilation, LAMA also exert anti-inflammatory and anti-fibrotic effects by inhibiting muscarinic receptors present in neutrophils, macrophages, fibroblasts and airway smooth muscle cells. Thus, besides bronchodilation, LAMA might provide additional therapeutic effects, thereby supporting an endotype-driven approach to asthma management. The Position Paper, developed by the Asthma Section of the European Academy of Allergy and Clinical Immunology, discusses the main cholinergic pathways in the lung, reviews the findings of significant clinical trials and real-life studies on LAMA use in asthma, examines the placement of these drugs in asthma clinical guidelines, and considers the potential for personalised medicine with LAMA in both adult and paediatric asthma patients.European Academy of Allergy and Clinical ImmunologyEuropean Academy of Allergy and Clinical ImmunologyWiley-Blackwel202620262024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/168589reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1685892026-06-07T06:28:51Z |
| dc.title.none.fl_str_mv |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper |
| title |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper |
| spellingShingle |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper Agache, I. Acetylcholine Asthma Bronchodilator Endotype Precision medicine Long-acting muscarinic antagonist Asthma Muscarinic Antagonists Acetylcholine Anti-Asthmatic Agents Bronchodilator Agents 3207.01 Alergias 3208.08 Mecanismos de Acción de Los Medicamentos 3205.08 Enfermedades Pulmonares asma acetilcolina antiasmáticos broncodilatadores antagonistas muscarínicos |
| title_short |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper |
| title_full |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper |
| title_fullStr |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper |
| title_full_unstemmed |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper |
| title_sort |
The bronchodilator and anti‐inflammatory effect of long‐Acting muscarinic antagonists in asthma: an EAACI position paper |
| dc.creator.none.fl_str_mv |
Agache, I. Adcock, I. M. Akdis, C. A. Akdis, M. Bentabol Ramos, G. van den Berge, M. Bocabella, C. Canonica, W. G. Caruso, C. Couto, M. Dávila González, Ignacio Jesús Drummond, D. Fonseca, J. Gherasim, A. del Giacco, S. Jackson, D. J. Jute, M. Licari, A. Loukides, S. Moreira, A. Mukherjee, M. Ojanguren, I. Palomares, O. Papi, A. Pérez del Llano, L. Price, O. J. Rukhazde, M. Shamji, M. H. Shaw, D. Sánchez García, S. Testera Montes, A. Torres, M. J. Eguiluz Gracia, I. |
| author |
Agache, I. |
| author_facet |
Agache, I. Adcock, I. M. Akdis, C. A. Akdis, M. Bentabol Ramos, G. van den Berge, M. Bocabella, C. Canonica, W. G. Caruso, C. Couto, M. Dávila González, Ignacio Jesús Drummond, D. Fonseca, J. Gherasim, A. del Giacco, S. Jackson, D. J. Jute, M. Licari, A. Loukides, S. Moreira, A. Mukherjee, M. Ojanguren, I. Palomares, O. Papi, A. Pérez del Llano, L. Price, O. J. Rukhazde, M. Shamji, M. H. Shaw, D. Sánchez García, S. Testera Montes, A. Torres, M. J. Eguiluz Gracia, I. |
| author_role |
author |
| author2 |
Adcock, I. M. Akdis, C. A. Akdis, M. Bentabol Ramos, G. van den Berge, M. Bocabella, C. Canonica, W. G. Caruso, C. Couto, M. Dávila González, Ignacio Jesús Drummond, D. Fonseca, J. Gherasim, A. del Giacco, S. Jackson, D. J. Jute, M. Licari, A. Loukides, S. Moreira, A. Mukherjee, M. Ojanguren, I. Palomares, O. Papi, A. Pérez del Llano, L. Price, O. J. Rukhazde, M. Shamji, M. H. Shaw, D. Sánchez García, S. Testera Montes, A. Torres, M. J. Eguiluz Gracia, I. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Acetylcholine Asthma Bronchodilator Endotype Precision medicine Long-acting muscarinic antagonist Asthma Muscarinic Antagonists Acetylcholine Anti-Asthmatic Agents Bronchodilator Agents 3207.01 Alergias 3208.08 Mecanismos de Acción de Los Medicamentos 3205.08 Enfermedades Pulmonares asma acetilcolina antiasmáticos broncodilatadores antagonistas muscarínicos |
| topic |
Acetylcholine Asthma Bronchodilator Endotype Precision medicine Long-acting muscarinic antagonist Asthma Muscarinic Antagonists Acetylcholine Anti-Asthmatic Agents Bronchodilator Agents 3207.01 Alergias 3208.08 Mecanismos de Acción de Los Medicamentos 3205.08 Enfermedades Pulmonares asma acetilcolina antiasmáticos broncodilatadores antagonistas muscarínicos |
| description |
[EN]As cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long-acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA improve lung function and reduce exacerbations in asthma patients who remained poorly controlled despite treatment with inhaled corticosteroids and long-acting β2 agonists. Asthma guidelines recommend LAMA as a third controller to be added on before the initiation of biologicals. In addition to bronchodilation, LAMA also exert anti-inflammatory and anti-fibrotic effects by inhibiting muscarinic receptors present in neutrophils, macrophages, fibroblasts and airway smooth muscle cells. Thus, besides bronchodilation, LAMA might provide additional therapeutic effects, thereby supporting an endotype-driven approach to asthma management. The Position Paper, developed by the Asthma Section of the European Academy of Allergy and Clinical Immunology, discusses the main cholinergic pathways in the lung, reviews the findings of significant clinical trials and real-life studies on LAMA use in asthma, examines the placement of these drugs in asthma clinical guidelines, and considers the potential for personalised medicine with LAMA in both adult and paediatric asthma patients. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10366/168589 |
| url |
http://hdl.handle.net/10366/168589 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Wiley-Blackwel |
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Wiley-Blackwel |
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reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL) |
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Universidad de Salamanca (USAL) |
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GREDOS. Repositorio Institucional de la Universidad de Salamanca |
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GREDOS. Repositorio Institucional de la Universidad de Salamanca |
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1869407337332080640 |
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15,198674 |