Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
Obesity has reached pandemic proportions worldwide and continues to increase alarmingly, making it urgent to understand the molecular mechanisms that regulate energy metabolism, as well as novel signals secreted by adipose tissue under both physiological and pathological conditions. Recently, extrac...
| Autor: | |
|---|---|
| Formato: | tesis doctoral |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:minerva_____::2826055c0e418f477681d97ba1c5a2b3 |
| Acesso em linha: | https://hdl.handle.net/10347/41590 |
| Access Level: | acceso abierto |
| Palavra-chave: | Obesity extracellular vesicle diabetes fatty liver adipose tissue 241104 Fisiología endocrina 320502 Endocrinología 320610 Enfermedades de la nutrición |
| Resumo: | Obesity has reached pandemic proportions worldwide and continues to increase alarmingly, making it urgent to understand the molecular mechanisms that regulate energy metabolism, as well as novel signals secreted by adipose tissue under both physiological and pathological conditions. Recently, extracellular vesicles (EVs) have emerged as key mediators of tissue-totissue communication, transporting RNA, proteins and lipids that influence inflammation, metabolism and other cellular functions. This thesis investigates the role of EVs in obesity, focusing on how vesicles secreted by different tissues (adipocytes, hepatocytes, macrophages) contribute to metabolic alterations such as insulin resistance and inflammation. Through in vitro and in vivo experimental models, the composition and functional effects of EVs have been analysed using advanced isolation and proteomic analysis techniques. |
|---|