The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization

11 Pág. Departamento de Reproducción Animal​ (INIA)

Detalhes bibliográficos
Autores: González-Brusi, Leopoldo, Hamzé, Julieta G., Lamas Toranzo, Ismael, Jiménez-Movilla, Maria, Bermejo Álvarez, Pablo
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/279787
Acesso em linha:http://hdl.handle.net/10261/279787
https://api.elsevier.com/content/abstract/scopus_id/85133303746
Access Level:Acceso aberto
Palavra-chave:TMEM95
Fertilization
Sperm
Olfactory receptor
Odorant
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spelling The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse FertilizationGonzález-Brusi, LeopoldoHamzé, Julieta G.Lamas Toranzo, IsmaelJiménez-Movilla, MariaBermejo Álvarez, PabloTMEM95FertilizationSpermOlfactory receptorOdorant11 Pág. Departamento de Reproducción Animal​ (INIA)Fertilization involves the fusion of two gametes by means of yet unknown membrane binding and fusion events. Over the last years, many sperm proteins have been uncovered to play essential roles in sperm-egg fusion in mammals, but their precise role in fertilization remains unknown, being unclear how these proteins interact with each other or with other yet unknown sperm proteins. The aim of this study has been to identify possible sperm proteins interacting with TMEM95, a protein essential for fertilization located in the sperm membrane. A list of 41 sperm proteins that were pulled down with TMEM95 and identified by mass spectrometry did not include other sperm proteins known to play a role in fertilization, suggesting an independent role of TMEM95 in fertilization. Between these lists, OLFR601 is allocated to the acrosomal region and may mediate affinity for an odorant involved in fertilization. However, Olfr601 disruption did not impair the sperm fertilization ability, suggesting that its function may be redundant with that of other sperm proteins.This work was supported by the projects AGL 2017-84908-R and PID 2020-117501RB-I00 to B-AP and PID 2020-114109GB-I00 to J-MM, funded by the Spanish Ministry of Science and Innovation and FEDER funds from the European Union.Peer reviewedFrontiers MediaMinisterio de Ciencia e Innovación (España)European CommissionL, González-Brusi [0000-0002-6371-6423]Lamas Toranzo, Ismael [0000-0002-7790-2649]Jiménez-Movilla, Maria [0000-0002-1572-8219]Bermejo Álvarez, Pablo [0000-0001-9907-2626]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/279787https://api.elsevier.com/content/abstract/scopus_id/85133303746reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-84908-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114109GB-I00Frontiers in cell and developmental biologyhttps://doi.org/10.3389/fcell.2022.854115Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2797872026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
title The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
spellingShingle The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
González-Brusi, Leopoldo
TMEM95
Fertilization
Sperm
Olfactory receptor
Odorant
title_short The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
title_full The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
title_fullStr The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
title_full_unstemmed The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
title_sort The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
dc.creator.none.fl_str_mv González-Brusi, Leopoldo
Hamzé, Julieta G.
Lamas Toranzo, Ismael
Jiménez-Movilla, Maria
Bermejo Álvarez, Pablo
author González-Brusi, Leopoldo
author_facet González-Brusi, Leopoldo
Hamzé, Julieta G.
Lamas Toranzo, Ismael
Jiménez-Movilla, Maria
Bermejo Álvarez, Pablo
author_role author
author2 Hamzé, Julieta G.
Lamas Toranzo, Ismael
Jiménez-Movilla, Maria
Bermejo Álvarez, Pablo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
European Commission
L, González-Brusi [0000-0002-6371-6423]
Lamas Toranzo, Ismael [0000-0002-7790-2649]
Jiménez-Movilla, Maria [0000-0002-1572-8219]
Bermejo Álvarez, Pablo [0000-0001-9907-2626]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv TMEM95
Fertilization
Sperm
Olfactory receptor
Odorant
topic TMEM95
Fertilization
Sperm
Olfactory receptor
Odorant
description 11 Pág. Departamento de Reproducción Animal​ (INIA)
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/279787
https://api.elsevier.com/content/abstract/scopus_id/85133303746
url http://hdl.handle.net/10261/279787
https://api.elsevier.com/content/abstract/scopus_id/85133303746
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-84908-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114109GB-I00
Frontiers in cell and developmental biology
https://doi.org/10.3389/fcell.2022.854115
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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