A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water

A sensitive, multi-residue method using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine a representative group of 35 analytes, including corrosion inhibitors, pesticides and pharmaceuticals such as analgesic and anti-inflammator...

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Autores: Valls Cantenys, Carme, Scheurer, Marco, Iglesias Juncà, Mònica, Sacher, Frank, Brauch, Heinz Jürgen, Salvadó Martín, Victòria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/13130
Acceso en línea:http://hdl.handle.net/10256/13130
Access Level:acceso embargado
Palabra clave:Cromatografia de líquids
Liquid chromatography
Contaminants emergents en l'aigua
Emerging contaminants in water
Aigua -- Contaminació
Water -- Pollution
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spelling A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in waterValls Cantenys, CarmeScheurer, MarcoIglesias Juncà, MònicaSacher, FrankBrauch, Heinz JürgenSalvadó Martín, VictòriaCromatografia de líquidsLiquid chromatographyContaminants emergents en l'aiguaEmerging contaminants in waterAigua -- ContaminacióWater -- PollutionA sensitive, multi-residue method using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine a representative group of 35 analytes, including corrosion inhibitors, pesticides and pharmaceuticals such as analgesic and anti-inflammatory drugs, five iodinated contrast media, β-blockers and some of their metabolites and transformation products in water samples. Few other methods are capable of determining such a broad range of contrast media together with other analytes. We studied the parameters affecting the extraction of the target analytes, including sorbent selection and extraction conditions, their chromatographic separation (mobile phase composition and column) and detection conditions using two ionisation sources: electrospray ionisation (ESI) and atmospheric pressure chemical ionisation (APCI). In order to correct matrix effects, a total of 20 surrogate/internal standards were used. ESI was found to have better sensitivity than APCI. Recoveries ranging from 79 to 134 % for tap water and 66 to 144 % for surface water were obtained. Intra-day precision, calculated as relative standard deviation, was below 34 % for tap water and below 21 % for surface water, groundwater and effluent wastewater. Method quantification limits (MQL) were in the low ng L−1 range, except for the contrast agents iomeprol, amidotrizoic acid and iohexol (22, 25.5 and 17.9 ng L−1, respectively). Finally, the method was applied to the analysis of 56 real water samples as part of the validation procedure. All of the compounds were detected in at least some of the water samples analysedThis study was financed by the SpanishMinistry of Science and Innovation through projects CTM2011-28765-C02-02 and CGL2013-48802-C3-2-R, and an FPI grant (Ref. BES-2009-024892) awarded to C. Valls-CantenysSpringer VerlagMinisterio de Ciencia e Innovación (Espanya)Ministerio de Economía y Competitividad (Espanya)infoinfo2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10256/13130http://hdl.handle.net/10256/13130© Analytical and Bioanalytical Chemistry, 2016, vol. 408, núm. 22, p. 6189-6200Articles publicats (D-Q)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00216-016-9731-5info:eu-repo/semantics/altIdentifier/issn/1618-2642info:eu-repo/semantics/altIdentifier/eissn/1618-2650info:eu-repo/grantAgreement/MICINN//CTM2011-28765-C02-02info:eu-repo/grantAgreement/MINECO//CGL2013-48802-C3-2-RTots els drets reservatsinfo:eu-repo/semantics/embargoedAccessoai:recercat.cat:10256/131302026-05-29T05:05:01Z
dc.title.none.fl_str_mv A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
title A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
spellingShingle A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
Valls Cantenys, Carme
Cromatografia de líquids
Liquid chromatography
Contaminants emergents en l'aigua
Emerging contaminants in water
Aigua -- Contaminació
Water -- Pollution
title_short A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
title_full A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
title_fullStr A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
title_full_unstemmed A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
title_sort A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
dc.creator.none.fl_str_mv Valls Cantenys, Carme
Scheurer, Marco
Iglesias Juncà, Mònica
Sacher, Frank
Brauch, Heinz Jürgen
Salvadó Martín, Victòria
author Valls Cantenys, Carme
author_facet Valls Cantenys, Carme
Scheurer, Marco
Iglesias Juncà, Mònica
Sacher, Frank
Brauch, Heinz Jürgen
Salvadó Martín, Victòria
author_role author
author2 Scheurer, Marco
Iglesias Juncà, Mònica
Sacher, Frank
Brauch, Heinz Jürgen
Salvadó Martín, Victòria
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (Espanya)
Ministerio de Economía y Competitividad (Espanya)
dc.subject.none.fl_str_mv Cromatografia de líquids
Liquid chromatography
Contaminants emergents en l'aigua
Emerging contaminants in water
Aigua -- Contaminació
Water -- Pollution
topic Cromatografia de líquids
Liquid chromatography
Contaminants emergents en l'aigua
Emerging contaminants in water
Aigua -- Contaminació
Water -- Pollution
description A sensitive, multi-residue method using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine a representative group of 35 analytes, including corrosion inhibitors, pesticides and pharmaceuticals such as analgesic and anti-inflammatory drugs, five iodinated contrast media, β-blockers and some of their metabolites and transformation products in water samples. Few other methods are capable of determining such a broad range of contrast media together with other analytes. We studied the parameters affecting the extraction of the target analytes, including sorbent selection and extraction conditions, their chromatographic separation (mobile phase composition and column) and detection conditions using two ionisation sources: electrospray ionisation (ESI) and atmospheric pressure chemical ionisation (APCI). In order to correct matrix effects, a total of 20 surrogate/internal standards were used. ESI was found to have better sensitivity than APCI. Recoveries ranging from 79 to 134 % for tap water and 66 to 144 % for surface water were obtained. Intra-day precision, calculated as relative standard deviation, was below 34 % for tap water and below 21 % for surface water, groundwater and effluent wastewater. Method quantification limits (MQL) were in the low ng L−1 range, except for the contrast agents iomeprol, amidotrizoic acid and iohexol (22, 25.5 and 17.9 ng L−1, respectively). Finally, the method was applied to the analysis of 56 real water samples as part of the validation procedure. All of the compounds were detected in at least some of the water samples analysed
publishDate 2016
dc.date.none.fl_str_mv 2016
info
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/13130
http://hdl.handle.net/10256/13130
url http://hdl.handle.net/10256/13130
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00216-016-9731-5
info:eu-repo/semantics/altIdentifier/issn/1618-2642
info:eu-repo/semantics/altIdentifier/eissn/1618-2650
info:eu-repo/grantAgreement/MICINN//CTM2011-28765-C02-02
info:eu-repo/grantAgreement/MINECO//CGL2013-48802-C3-2-R
dc.rights.none.fl_str_mv Tots els drets reservats
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Tots els drets reservats
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv © Analytical and Bioanalytical Chemistry, 2016, vol. 408, núm. 22, p. 6189-6200
Articles publicats (D-Q)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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