Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis

Outdoor exposure is considered the primary modifiable risk factor in preventing the development of myopia. This effect is thought to be attributed to the light-induced synthesis and release of dopamine in the retina. However, until recent years, there was no objective quantifiable method available t...

Full description

Bibliographic Details
Authors: Gutiérrez Rodríguez, Natali, Ortega Claici, Aura, Ramos Castaneda, Jorge A., González Zamora, Jorge, Bilbao Malavé, Valentina, Puente, Miriam de la, Fernández Robredo, Patricia, Garzón Parra, Sandra Johanna, Garza León, Manuel, Recalde Maestre, Sergio
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/211304
Online Access:https://hdl.handle.net/2445/211304
Access Level:Open access
Keyword:Miopia
Vida a l'aire lliure
Medicina preventiva
Myopia
Outdoor life
Preventive medicine
id ES_412e8204b3a25517aed5da4e21ba55ab
oai_identifier_str oai:diposit.ub.edu:2445/211304
network_acronym_str ES
network_name_str España
repository_id_str
spelling Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysisGutiérrez Rodríguez, NataliOrtega Claici, AuraRamos Castaneda, Jorge A.González Zamora, JorgeBilbao Malavé, ValentinaPuente, Miriam de laFernández Robredo, PatriciaGarzón Parra, Sandra JohannaGarza León, ManuelRecalde Maestre, SergioMiopiaVida a l'aire lliureMedicina preventivaMyopiaOutdoor lifePreventive medicineOutdoor exposure is considered the primary modifiable risk factor in preventing the development of myopia. This effect is thought to be attributed to the light-induced synthesis and release of dopamine in the retina. However, until recent years, there was no objective quantifiable method available to measure the association between time spent outdoors and myopia. It is only recently that the conjunctival ultraviolet autofluorescence (CUVAF) area, serving as a biomarker for sun exposure, has begun to be utilized in numerous studies. To provide a comprehensive summary of the relevant evidence pertaining to the association between the CUVAF area and myopia across different geographic regions and age groups, a systematic review and meta-analysis were conducted. The search encompassed multiple databases, including MEDLINE, SCIENCE DIRECT, GOOGLE SCHOLAR, WEB OF SCIENCE, and SCOPUS, and utilized specific search terms such as conjunctival ultraviolet autofluorescence, CUVAF, UVAF, objective marker of ocular sun exposure, myopia, degenerative myopia, and high myopia. The bibliographic research included papers published between the years 2006 and 2022. A total of 4051 records were initially identified, and after duplicates were removed, 49 articles underwent full-text review. Nine articles were included in the systematic review. These studies covered myopia and outdoor exposure across different regions (Australia, Europe and India) with a total population of 3615 individuals. They found that myopes generally had smaller CUVAF areas compared to non-myopes. The meta-analysis confirmed this, revealing statistically smaller CUVAF areas in myopic patients, with a mean difference of - 3.30 mm2 (95% CI - 5.53; - 1.06). Additionally, some studies showed a positive correlation between more outdoor exposure and larger CUVAF areas. In terms of outdoor exposure time, myopic patients reported less time outdoors than non-myopic individuals, with a mean difference of - 3.38 h/week (95% CI - 4.66; - 2.09). Overall, these findings highlight the connection between outdoor exposure, CUVAF area and myopia, with regional variations playing a significant role. The results of this meta-analysis validate CUVAF as a quantitative method to objectively measure outdoor exposure in relation with myopia development.Springer Science and Business Media LLC2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/211304Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-024-51417-9Scientific Reports, 2024, vol. 14, num. 1https://doi.org/10.1038/s41598-024-51417-9cc by (c) Gutiérrez Rodríguez, Natali et al, 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2113042026-05-27T06:46:51Z
dc.title.none.fl_str_mv Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
title Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
spellingShingle Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
Gutiérrez Rodríguez, Natali
Miopia
Vida a l'aire lliure
Medicina preventiva
Myopia
Outdoor life
Preventive medicine
title_short Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
title_full Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
title_fullStr Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
title_full_unstemmed Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
title_sort Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis
dc.creator.none.fl_str_mv Gutiérrez Rodríguez, Natali
Ortega Claici, Aura
Ramos Castaneda, Jorge A.
González Zamora, Jorge
Bilbao Malavé, Valentina
Puente, Miriam de la
Fernández Robredo, Patricia
Garzón Parra, Sandra Johanna
Garza León, Manuel
Recalde Maestre, Sergio
author Gutiérrez Rodríguez, Natali
author_facet Gutiérrez Rodríguez, Natali
Ortega Claici, Aura
Ramos Castaneda, Jorge A.
González Zamora, Jorge
Bilbao Malavé, Valentina
Puente, Miriam de la
Fernández Robredo, Patricia
Garzón Parra, Sandra Johanna
Garza León, Manuel
Recalde Maestre, Sergio
author_role author
author2 Ortega Claici, Aura
Ramos Castaneda, Jorge A.
González Zamora, Jorge
Bilbao Malavé, Valentina
Puente, Miriam de la
Fernández Robredo, Patricia
Garzón Parra, Sandra Johanna
Garza León, Manuel
Recalde Maestre, Sergio
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Miopia
Vida a l'aire lliure
Medicina preventiva
Myopia
Outdoor life
Preventive medicine
topic Miopia
Vida a l'aire lliure
Medicina preventiva
Myopia
Outdoor life
Preventive medicine
description Outdoor exposure is considered the primary modifiable risk factor in preventing the development of myopia. This effect is thought to be attributed to the light-induced synthesis and release of dopamine in the retina. However, until recent years, there was no objective quantifiable method available to measure the association between time spent outdoors and myopia. It is only recently that the conjunctival ultraviolet autofluorescence (CUVAF) area, serving as a biomarker for sun exposure, has begun to be utilized in numerous studies. To provide a comprehensive summary of the relevant evidence pertaining to the association between the CUVAF area and myopia across different geographic regions and age groups, a systematic review and meta-analysis were conducted. The search encompassed multiple databases, including MEDLINE, SCIENCE DIRECT, GOOGLE SCHOLAR, WEB OF SCIENCE, and SCOPUS, and utilized specific search terms such as conjunctival ultraviolet autofluorescence, CUVAF, UVAF, objective marker of ocular sun exposure, myopia, degenerative myopia, and high myopia. The bibliographic research included papers published between the years 2006 and 2022. A total of 4051 records were initially identified, and after duplicates were removed, 49 articles underwent full-text review. Nine articles were included in the systematic review. These studies covered myopia and outdoor exposure across different regions (Australia, Europe and India) with a total population of 3615 individuals. They found that myopes generally had smaller CUVAF areas compared to non-myopes. The meta-analysis confirmed this, revealing statistically smaller CUVAF areas in myopic patients, with a mean difference of - 3.30 mm2 (95% CI - 5.53; - 1.06). Additionally, some studies showed a positive correlation between more outdoor exposure and larger CUVAF areas. In terms of outdoor exposure time, myopic patients reported less time outdoors than non-myopic individuals, with a mean difference of - 3.38 h/week (95% CI - 4.66; - 2.09). Overall, these findings highlight the connection between outdoor exposure, CUVAF area and myopia, with regional variations playing a significant role. The results of this meta-analysis validate CUVAF as a quantitative method to objectively measure outdoor exposure in relation with myopia development.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/211304
url https://hdl.handle.net/2445/211304
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-024-51417-9
Scientific Reports, 2024, vol. 14, num. 1
https://doi.org/10.1038/s41598-024-51417-9
dc.rights.none.fl_str_mv cc by (c) Gutiérrez Rodríguez, Natali et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Gutiérrez Rodríguez, Natali et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media LLC
publisher.none.fl_str_mv Springer Science and Business Media LLC
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406828833538048
score 15,301629

Similar Items