Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis

While the scientific community has long acknowledged the significant role of serendipity in shaping the field of contemporary psychopharmacology, its impact has not undergone a comprehensive analysis using operational methodologies. Serendipity, originally defined as discoveries stemming from a blen...

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Detalhes bibliográficos
Autores: López-Muñoz, Francisco, D'Ocón, Pilar, Romero Martínez, Manuel Alejandro, Guerra Guirao, José Antonio, De Berardis, Domenico, Álamo, Cecilio
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/105910
Acesso em linha:https://hdl.handle.net/20.500.14352/105910
Access Level:acceso abierto
Palavra-chave:615.9
Toxicología (Farmacia)
3214 Toxicología
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spelling Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical AnalysisLópez-Muñoz, FranciscoD'Ocón, PilarRomero Martínez, Manuel AlejandroGuerra Guirao, José AntonioDe Berardis, DomenicoÁlamo, Cecilio615.9Toxicología (Farmacia)3214 ToxicologíaWhile the scientific community has long acknowledged the significant role of serendipity in shaping the field of contemporary psychopharmacology, its impact has not undergone a comprehensive analysis using operational methodologies. Serendipity, originally defined as discoveries stemming from a blend of luck and astuteness by Walpole, has been operationalized by our research group. Our definition builds upon Walpole’s notion of fortuitous accidents and keen insight leading to the unexpected revelation of something unintended. We have discerned four unique serendipitous attributability patterns. In this paper, we delve into the historical aspect of how serendipity has played a role in the discovery and advancement of drugs approved for addressing different stages of bipolar disorder. The revelation of valproate’s antimanic properties aligns with the pure serendipitous pattern (type I). Conversely, the discovery of lithium’s antimanic effects corresponds to the mixed type II pattern, where the initial serendipitous observation of sedation in research animals, prompted by adding lithium salts to enhance uric acid solubility, led to the planned discovery of its calming impact on manic patients. On the contrary, the recognition of the mood-stabilizing attributes of lamotrigine aligns with the type III archetype. This particular pattern is defined by serendipity emerging as a consequence of a discovery that was initially nonserendipitous, as mood-stabilizing efficacy was incidentally observed during the treatment of epileptic patients for whom the drug was originally developed. Finally, carbamazepine and, notably, atypical antipsychotics fall within the type IV pattern. In this category, serendipity is entirely absent, as the antimanic use of carbamazepine was a straightforward extension of the use of other antiepileptic drugs. Atypical antipsychotics were introduced into bipolar disorder therapy through a deliberate and targeted design process, seeking drugs capable of acting on specific biological targets.WileyUniversidad Complutense de Madrid20242024-06-2020242024-06-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/105910reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1059102026-06-02T12:44:21Z
dc.title.none.fl_str_mv Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
title Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
spellingShingle Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
López-Muñoz, Francisco
615.9
Toxicología (Farmacia)
3214 Toxicología
title_short Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
title_full Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
title_fullStr Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
title_full_unstemmed Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
title_sort Discovery Patterns of Drugs Approved for Treating Bipolar Disorder by Applying Operational Criteria of Serendipity: A Historical Analysis
dc.creator.none.fl_str_mv López-Muñoz, Francisco
D'Ocón, Pilar
Romero Martínez, Manuel Alejandro
Guerra Guirao, José Antonio
De Berardis, Domenico
Álamo, Cecilio
author López-Muñoz, Francisco
author_facet López-Muñoz, Francisco
D'Ocón, Pilar
Romero Martínez, Manuel Alejandro
Guerra Guirao, José Antonio
De Berardis, Domenico
Álamo, Cecilio
author_role author
author2 D'Ocón, Pilar
Romero Martínez, Manuel Alejandro
Guerra Guirao, José Antonio
De Berardis, Domenico
Álamo, Cecilio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.9
Toxicología (Farmacia)
3214 Toxicología
topic 615.9
Toxicología (Farmacia)
3214 Toxicología
description While the scientific community has long acknowledged the significant role of serendipity in shaping the field of contemporary psychopharmacology, its impact has not undergone a comprehensive analysis using operational methodologies. Serendipity, originally defined as discoveries stemming from a blend of luck and astuteness by Walpole, has been operationalized by our research group. Our definition builds upon Walpole’s notion of fortuitous accidents and keen insight leading to the unexpected revelation of something unintended. We have discerned four unique serendipitous attributability patterns. In this paper, we delve into the historical aspect of how serendipity has played a role in the discovery and advancement of drugs approved for addressing different stages of bipolar disorder. The revelation of valproate’s antimanic properties aligns with the pure serendipitous pattern (type I). Conversely, the discovery of lithium’s antimanic effects corresponds to the mixed type II pattern, where the initial serendipitous observation of sedation in research animals, prompted by adding lithium salts to enhance uric acid solubility, led to the planned discovery of its calming impact on manic patients. On the contrary, the recognition of the mood-stabilizing attributes of lamotrigine aligns with the type III archetype. This particular pattern is defined by serendipity emerging as a consequence of a discovery that was initially nonserendipitous, as mood-stabilizing efficacy was incidentally observed during the treatment of epileptic patients for whom the drug was originally developed. Finally, carbamazepine and, notably, atypical antipsychotics fall within the type IV pattern. In this category, serendipity is entirely absent, as the antimanic use of carbamazepine was a straightforward extension of the use of other antiepileptic drugs. Atypical antipsychotics were introduced into bipolar disorder therapy through a deliberate and targeted design process, seeking drugs capable of acting on specific biological targets.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-06-20
2024
2024-06-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/105910
url https://hdl.handle.net/20.500.14352/105910
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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