Associations between clinical canine leishmaniosis and multiple vector-borne co-infections

Background: Dogs that have clinical leishmaniosis (ClinL), caused by the parasite Leishmania infantum, are commonly co-infected with other pathogens, especially vector-borne pathogens (VBP). A recent PCR-based study found that ClinL dogs are more likely to be additionally infected with the rickettsi...

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Autores: Attipa, Charalampos|||0000-0001-6039-6586, Solano Gallego, Laia.|||0000-0001-8479-4896, Leutenegger, Christian M., Papasouliotis, Kostas, Soutter, Francesca, Balzer, Jörg, Carver, Scott, Buch, Jesse S., Tasker, Séverine|||0000-0002-4059-1402
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:223629
Acesso em linha:https://ddd.uab.cat/record/223629
https://dx.doi.org/urn:doi:10.1186/s12917-019-2083-6
Access Level:acceso abierto
Palavra-chave:Gossos
Leishmaniosi
Ehrlichia canis
Borrelia burgdorferi
Acanthocheilonema reconditum
Vectorborne pathogen
Co-infection
Cyprus
Leishmania infantum
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spelling Associations between clinical canine leishmaniosis and multiple vector-borne co-infectionsA case-control serological studyAttipa, Charalampos|||0000-0001-6039-6586Solano Gallego, Laia.|||0000-0001-8479-4896Leutenegger, Christian M.Papasouliotis, KostasSoutter, FrancescaBalzer, JörgCarver, ScottBuch, Jesse S.Tasker, Séverine|||0000-0002-4059-1402GossosLeishmaniosiEhrlichia canisBorrelia burgdorferiAcanthocheilonema reconditumVectorborne pathogenCo-infectionCyprusLeishmania infantumBackground: Dogs that have clinical leishmaniosis (ClinL), caused by the parasite Leishmania infantum, are commonly co-infected with other pathogens, especially vector-borne pathogens (VBP). A recent PCR-based study found that ClinL dogs are more likely to be additionally infected with the rickettsial bacteria Ehrlichia canis. Further information on co-infections in ClinL cases with VBP, as assessed by serology, is required. The research described in this report determined if dogs with ClinL are at higher risk of exposure to VBP than healthy control dogs using a case-control serology study. Results: Of the 47 dogs with ClinL, anti-E. canis/Ehrlichia ewingii antibodies were detected in 17 (36.2%), anti-Anaplasma phagocytophilum/Anaplasma platys antibodies in 5 (10.6%) and antigen for Dirofilaria immitis in 2 (4.3%). Of the 87 control dogs, anti-E. canis/E. ewingii antibodies were detected in 14 (16.1%) and anti-A. phagocytophilum/A. platys antibodies in 2 (2.3%). No anti-Borrelia burgdorferi antibody tests were positive. No statistical differences between the ClinL dogs and control dogs regarding lifestyle or use of ectoparasitic prevention, were identified. The ClinL was significantly associated with anti-E. canis/E. ewingii antibodies (odds ratio = 2.9, 95% confidence interval: 1.3-6.7, P = 0.010) compared to controls by both multivariable logistic regression and structural equation modelling. Conclusions: It was demonstrated that an increased risk for E. canis/E. ewingii seropositivity is present in dogs with ClinL compared to clinically healthy control dogs, despite similar ectoparasitic prevention use and lifestyle. Based on these findings it is suggested that dogs with ClinL should not only be tested for E. canis co-infection using PCR but also serologically for E. canis/E. ewingii. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/223629https://dx.doi.org/urn:doi:10.1186/s12917-019-2083-6reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2236292026-06-06T12:50:31Z
dc.title.none.fl_str_mv Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
A case-control serological study
title Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
spellingShingle Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
Attipa, Charalampos|||0000-0001-6039-6586
Gossos
Leishmaniosi
Ehrlichia canis
Borrelia burgdorferi
Acanthocheilonema reconditum
Vectorborne pathogen
Co-infection
Cyprus
Leishmania infantum
title_short Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
title_full Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
title_fullStr Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
title_full_unstemmed Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
title_sort Associations between clinical canine leishmaniosis and multiple vector-borne co-infections
dc.creator.none.fl_str_mv Attipa, Charalampos|||0000-0001-6039-6586
Solano Gallego, Laia.|||0000-0001-8479-4896
Leutenegger, Christian M.
Papasouliotis, Kostas
Soutter, Francesca
Balzer, Jörg
Carver, Scott
Buch, Jesse S.
Tasker, Séverine|||0000-0002-4059-1402
author Attipa, Charalampos|||0000-0001-6039-6586
author_facet Attipa, Charalampos|||0000-0001-6039-6586
Solano Gallego, Laia.|||0000-0001-8479-4896
Leutenegger, Christian M.
Papasouliotis, Kostas
Soutter, Francesca
Balzer, Jörg
Carver, Scott
Buch, Jesse S.
Tasker, Séverine|||0000-0002-4059-1402
author_role author
author2 Solano Gallego, Laia.|||0000-0001-8479-4896
Leutenegger, Christian M.
Papasouliotis, Kostas
Soutter, Francesca
Balzer, Jörg
Carver, Scott
Buch, Jesse S.
Tasker, Séverine|||0000-0002-4059-1402
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Gossos
Leishmaniosi
Ehrlichia canis
Borrelia burgdorferi
Acanthocheilonema reconditum
Vectorborne pathogen
Co-infection
Cyprus
Leishmania infantum
topic Gossos
Leishmaniosi
Ehrlichia canis
Borrelia burgdorferi
Acanthocheilonema reconditum
Vectorborne pathogen
Co-infection
Cyprus
Leishmania infantum
description Background: Dogs that have clinical leishmaniosis (ClinL), caused by the parasite Leishmania infantum, are commonly co-infected with other pathogens, especially vector-borne pathogens (VBP). A recent PCR-based study found that ClinL dogs are more likely to be additionally infected with the rickettsial bacteria Ehrlichia canis. Further information on co-infections in ClinL cases with VBP, as assessed by serology, is required. The research described in this report determined if dogs with ClinL are at higher risk of exposure to VBP than healthy control dogs using a case-control serology study. Results: Of the 47 dogs with ClinL, anti-E. canis/Ehrlichia ewingii antibodies were detected in 17 (36.2%), anti-Anaplasma phagocytophilum/Anaplasma platys antibodies in 5 (10.6%) and antigen for Dirofilaria immitis in 2 (4.3%). Of the 87 control dogs, anti-E. canis/E. ewingii antibodies were detected in 14 (16.1%) and anti-A. phagocytophilum/A. platys antibodies in 2 (2.3%). No anti-Borrelia burgdorferi antibody tests were positive. No statistical differences between the ClinL dogs and control dogs regarding lifestyle or use of ectoparasitic prevention, were identified. The ClinL was significantly associated with anti-E. canis/E. ewingii antibodies (odds ratio = 2.9, 95% confidence interval: 1.3-6.7, P = 0.010) compared to controls by both multivariable logistic regression and structural equation modelling. Conclusions: It was demonstrated that an increased risk for E. canis/E. ewingii seropositivity is present in dogs with ClinL compared to clinically healthy control dogs, despite similar ectoparasitic prevention use and lifestyle. Based on these findings it is suggested that dogs with ClinL should not only be tested for E. canis co-infection using PCR but also serologically for E. canis/E. ewingii.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/223629
https://dx.doi.org/urn:doi:10.1186/s12917-019-2083-6
url https://ddd.uab.cat/record/223629
https://dx.doi.org/urn:doi:10.1186/s12917-019-2083-6
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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