Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.

Castells-Sánchez A; Roig-Coll F; Dacosta-Aguayo R; Lamonja-Vicente N; Sawicka AK; Torán-Monserrat P; Pera G; Montero-Alía P; Heras-Tebar A; Domènech S; Via M; Erickson KI; Mataró M

Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.

Background: Although exercise is known to have a neuroprotective effect in aging, the mediators underlying the exercise-cognition association remain poorly understood. In this paper we aimed to study the molecular, brain, and behavioral changes related to physical activity and their potential role a...

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Autores:	Castells-Sánchez A, Roig-Coll F, Dacosta-Aguayo R, Lamonja-Vicente N, Sawicka AK, Torán-Monserrat P, Pera G, Montero-Alía P, Heras-Tebar A, Domènech S, Via M, Erickson KI, Mataró M
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Recursos:	Fundació Sant Joan de Déu
Repositorio:	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:	oai:fsjd.fundanetsuite.com:p19335
Acesso em linha:	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19335 https://www.frontiersin.org/articles/10.3389/fnagi.2021.615247/full
Access Level:	acceso abierto
Palavra-chave:	brain volume cognition exercise fitness molecular biomarkers psychological health

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spelling	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.Castells-Sánchez ARoig-Coll FDacosta-Aguayo RLamonja-Vicente NSawicka AKTorán-Monserrat PPera GMontero-Alía PHeras-Tebar ADomènech SVia MErickson KIMataró Mbrain volumecognitionexercisefitnessmolecular biomarkerspsychological healthBackground: Although exercise is known to have a neuroprotective effect in aging, the mediators underlying the exercise-cognition association remain poorly understood. In this paper we aimed to study the molecular, brain, and behavioral changes related to physical activity and their potential role as mediators. Methods: We obtained demographic, physical activity outcomes [sportive physical activity and cardiorespiratory fitness (CRF)], plasma biomarkers (TNF-a, ICAM-1, HGF, SDF1-a, and BDNF), structural-MRI (brain volume areas), psychological and sleep health (mood, depressive and distress symptoms, and sleep quality), and multi-domain cognitive data from 115 adults aged 50-70 years. We conducted linear regression models and mediation analyses stratifying results by sex in a final sample of 104 individuals [65 women (age = 56.75 ± 4.96) and 39 men (age = 58.59 ± 5.86)]. Results: Women engaging in greater amounts of exercising showed lower TNF-a levels and greater dorsolateral prefrontal cortex and temporal lobe volumes. Men engaging in greater amounts of exercise showed greater temporal lobe volumes. CRF levels were not related to any of the analyzed outcomes in women but in men higher CRF was associated with lower TNF-a, HGF and ventricle volumes, greater volume of temporal and parietal lobes and fewer depressive symptoms and better mood. In men, reduced TNF-a and HGF levels mediated brain and cognitive CRF-related benefits. Conclusion: Our results show that exercise is a promising approach for influencing inflammation and brain volume and also contributes to ongoing discussions about the physiological mediators for the association between CRF and cognition in men.FRONTIERS MEDIA SA2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19335https://www.frontiersin.org/articles/10.3389/fnagi.2021.615247/fullFrontiers in Aging NeuroscienceISSN: 16634365reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p193352026-05-27T12:37:41Z
dc.title.none.fl_str_mv	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.
title	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.
spellingShingle	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men. Castells-Sánchez A brain volume cognition exercise fitness molecular biomarkers psychological health
title_short	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.
title_full	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.
title_fullStr	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.
title_full_unstemmed	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.
title_sort	Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.
dc.creator.none.fl_str_mv	Castells-Sánchez A Roig-Coll F Dacosta-Aguayo R Lamonja-Vicente N Sawicka AK Torán-Monserrat P Pera G Montero-Alía P Heras-Tebar A Domènech S Via M Erickson KI Mataró M
author	Castells-Sánchez A
author_facet	Castells-Sánchez A Roig-Coll F Dacosta-Aguayo R Lamonja-Vicente N Sawicka AK Torán-Monserrat P Pera G Montero-Alía P Heras-Tebar A Domènech S Via M Erickson KI Mataró M
author_role	author
author2	Roig-Coll F Dacosta-Aguayo R Lamonja-Vicente N Sawicka AK Torán-Monserrat P Pera G Montero-Alía P Heras-Tebar A Domènech S Via M Erickson KI Mataró M
author2_role	author author author author author author author author author author author author
dc.subject.none.fl_str_mv	brain volume cognition exercise fitness molecular biomarkers psychological health
topic	brain volume cognition exercise fitness molecular biomarkers psychological health
description	Background: Although exercise is known to have a neuroprotective effect in aging, the mediators underlying the exercise-cognition association remain poorly understood. In this paper we aimed to study the molecular, brain, and behavioral changes related to physical activity and their potential role as mediators. Methods: We obtained demographic, physical activity outcomes [sportive physical activity and cardiorespiratory fitness (CRF)], plasma biomarkers (TNF-a, ICAM-1, HGF, SDF1-a, and BDNF), structural-MRI (brain volume areas), psychological and sleep health (mood, depressive and distress symptoms, and sleep quality), and multi-domain cognitive data from 115 adults aged 50-70 years. We conducted linear regression models and mediation analyses stratifying results by sex in a final sample of 104 individuals [65 women (age = 56.75 ± 4.96) and 39 men (age = 58.59 ± 5.86)]. Results: Women engaging in greater amounts of exercising showed lower TNF-a levels and greater dorsolateral prefrontal cortex and temporal lobe volumes. Men engaging in greater amounts of exercise showed greater temporal lobe volumes. CRF levels were not related to any of the analyzed outcomes in women but in men higher CRF was associated with lower TNF-a, HGF and ventricle volumes, greater volume of temporal and parietal lobes and fewer depressive symptoms and better mood. In men, reduced TNF-a and HGF levels mediated brain and cognitive CRF-related benefits. Conclusion: Our results show that exercise is a promising approach for influencing inflammation and brain volume and also contributes to ongoing discussions about the physiological mediators for the association between CRF and cognition in men.
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19335 https://www.frontiersin.org/articles/10.3389/fnagi.2021.615247/full
url	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19335 https://www.frontiersin.org/articles/10.3389/fnagi.2021.615247/full
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	FRONTIERS MEDIA SA
publisher.none.fl_str_mv	FRONTIERS MEDIA SA
dc.source.none.fl_str_mv	Frontiers in Aging Neuroscience ISSN: 16634365 reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname:Fundació Sant Joan de Déu
instname_str	Fundació Sant Joan de Déu
reponame_str	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,228081

Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.

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