Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides

Aim: Development of fluorometholone-loaded PEG-PLGA nanoparticles (NPs) functionalized with cellpenetrating peptides for the treatment of ocular inflammatory disorders. Materials & methods: Synthesized polymers and peptides were used for elaboration of functionalized NPs, which were characterize...

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Detalhes bibliográficos
Autores: González Pizarro, Roberto Carlos, Parrotta, Graziella, Vera-García, Rodrigo, Sánchez-López, E. (Elena), Galindo Camacho, Ruth Milagros, Kjeldsen, Frank, Badía Palacín, Josefa, Baldomà Llavinés, Laura, Espina García, Marta, García López, María Luisa
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/164191
Acesso em linha:https://hdl.handle.net/2445/164191
Access Level:acceso abierto
Palavra-chave:Farmacologia ocular
Agents antiinflamatoris
Sistemes d'alliberament de medicaments
Nanopartícules
Uveïtis
Polímers
Pèptids
Ocular pharmacology
Antiinflammatory agents
Drug delivery systems
Nanoparticles
Uveitis
Polymers
Peptides
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oai_identifier_str oai:diposit.ub.edu:2445/164191
network_acronym_str ES
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repository_id_str
spelling Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptidesGonzález Pizarro, Roberto CarlosParrotta, GraziellaVera-García, RodrigoSánchez-López, E. (Elena)Galindo Camacho, Ruth MilagrosKjeldsen, FrankBadía Palacín, JosefaBaldomà Llavinés, LauraEspina García, MartaGarcía López, María LuisaFarmacologia ocularAgents antiinflamatorisSistemes d'alliberament de medicamentsNanopartículesUveïtisPolímersPèptidsOcular pharmacologyAntiinflammatory agentsDrug delivery systemsNanoparticlesUveitisPolymersPeptidesAim: Development of fluorometholone-loaded PEG-PLGA nanoparticles (NPs) functionalized with cellpenetrating peptides for the treatment of ocular inflammatory disorders. Materials & methods: Synthesized polymers and peptides were used for elaboration of functionalized NPs, which were characterized physicochemically. Cytotoxicity and ability to modulate the expression of proinflammatory cytokines were evaluated in vitro using human corneal epithelial cells (HCE-2). NP uptake was assayed in both in vitro and in vivo models. Results: NPs showed physicochemical characteristics suitable for ocular administration without evidence of cytotoxicity. TAT-NPs and G2-NPs were internalized and displayed anti-inflammatory activity in both HCE-2 cells and mouse eye. Conclusion: TAT-NPs and G2-NPs could be considered a novel strategy for the treatment of ocular inflammatory diseases of the anterior and posterior segment.Future Medicine2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/164191Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.2217/nnm-2019-0201Nanomedicine, 2019, vol. 14, num. 23, p. 3089-3104https://doi.org/10.2217/nnm-2019-0201info:eu-repo/grantAgreement/EC/H2020/646603(c) Future Medicine, 2019info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1641912026-05-27T06:46:51Z
dc.title.none.fl_str_mv Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
title Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
spellingShingle Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
González Pizarro, Roberto Carlos
Farmacologia ocular
Agents antiinflamatoris
Sistemes d'alliberament de medicaments
Nanopartícules
Uveïtis
Polímers
Pèptids
Ocular pharmacology
Antiinflammatory agents
Drug delivery systems
Nanoparticles
Uveitis
Polymers
Peptides
title_short Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
title_full Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
title_fullStr Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
title_full_unstemmed Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
title_sort Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
dc.creator.none.fl_str_mv González Pizarro, Roberto Carlos
Parrotta, Graziella
Vera-García, Rodrigo
Sánchez-López, E. (Elena)
Galindo Camacho, Ruth Milagros
Kjeldsen, Frank
Badía Palacín, Josefa
Baldomà Llavinés, Laura
Espina García, Marta
García López, María Luisa
author González Pizarro, Roberto Carlos
author_facet González Pizarro, Roberto Carlos
Parrotta, Graziella
Vera-García, Rodrigo
Sánchez-López, E. (Elena)
Galindo Camacho, Ruth Milagros
Kjeldsen, Frank
Badía Palacín, Josefa
Baldomà Llavinés, Laura
Espina García, Marta
García López, María Luisa
author_role author
author2 Parrotta, Graziella
Vera-García, Rodrigo
Sánchez-López, E. (Elena)
Galindo Camacho, Ruth Milagros
Kjeldsen, Frank
Badía Palacín, Josefa
Baldomà Llavinés, Laura
Espina García, Marta
García López, María Luisa
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Farmacologia ocular
Agents antiinflamatoris
Sistemes d'alliberament de medicaments
Nanopartícules
Uveïtis
Polímers
Pèptids
Ocular pharmacology
Antiinflammatory agents
Drug delivery systems
Nanoparticles
Uveitis
Polymers
Peptides
topic Farmacologia ocular
Agents antiinflamatoris
Sistemes d'alliberament de medicaments
Nanopartícules
Uveïtis
Polímers
Pèptids
Ocular pharmacology
Antiinflammatory agents
Drug delivery systems
Nanoparticles
Uveitis
Polymers
Peptides
description Aim: Development of fluorometholone-loaded PEG-PLGA nanoparticles (NPs) functionalized with cellpenetrating peptides for the treatment of ocular inflammatory disorders. Materials & methods: Synthesized polymers and peptides were used for elaboration of functionalized NPs, which were characterized physicochemically. Cytotoxicity and ability to modulate the expression of proinflammatory cytokines were evaluated in vitro using human corneal epithelial cells (HCE-2). NP uptake was assayed in both in vitro and in vivo models. Results: NPs showed physicochemical characteristics suitable for ocular administration without evidence of cytotoxicity. TAT-NPs and G2-NPs were internalized and displayed anti-inflammatory activity in both HCE-2 cells and mouse eye. Conclusion: TAT-NPs and G2-NPs could be considered a novel strategy for the treatment of ocular inflammatory diseases of the anterior and posterior segment.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/164191
url https://hdl.handle.net/2445/164191
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.2217/nnm-2019-0201
Nanomedicine, 2019, vol. 14, num. 23, p. 3089-3104
https://doi.org/10.2217/nnm-2019-0201
info:eu-repo/grantAgreement/EC/H2020/646603
dc.rights.none.fl_str_mv (c) Future Medicine, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Future Medicine, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406381634748416
score 15,228081

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