Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitocho...

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Autores: Alarcón-Gil, Jesús, Sierra-Magro, Ana, Morales-García, José A., Sanz-SanCristóbal, Marina, Alonso-Gil, Sandra, Cortés-Canteli, Marta, Niso-Santano, Mireia, Martinez-Chacon, Guadalupe, Fuentes, José M., Santos, Ángel, Pérez-Castillo, Ana
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/289766
Acesso em linha:http://hdl.handle.net/10261/289766
Access Level:acceso abierto
Palavra-chave:Autophagy
Lipophagy
Neurodegeneration
Lipid droplets
Oxidative Stress
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spelling Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagyAlarcón-Gil, JesúsSierra-Magro, AnaMorales-García, José A.Sanz-SanCristóbal, MarinaAlonso-Gil, SandraCortés-Canteli, MartaNiso-Santano, MireiaMartinez-Chacon, GuadalupeFuentes, José M.Santos, ÁngelPérez-Castillo, AnaAutophagyLipophagyNeurodegenerationLipid dropletsOxidative StressParkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitochondrial dysfunction, loss of proteostasis, and autophagy impairment. Moreover, in recent years, lipid metabolism alterations have become relevant in PD pathogeny. The modification of lipid metabolism has become a possible way to treat the disease. Because of this, we analyzed the effect and possible mechanism of action of linoleic acid (LA) on an SH-SY5Y PD cell line model and a PD mouse model, both induced by 6-hydroxydopamine (6-OHDA) treatment. The results show that LA acts as a potent neuroprotective and anti-inflammatory agent in these PD models. We also observed that LA stimulates the biogenesis of lipid droplets and improves the autophagy/lipophagy flux, which resulted in an antioxidant effect in the in vitro PD model. In summary, we confirmed the neuroprotective effect of LA in vitro and in vivo against PD. We also obtained some clues about the novel neuroprotective mechanism of LA against PD through the regulation of lipid droplet dynamics.This research was supported by the Health Institute “Carlos III”-CIBERNED (CB06/05/0041 and 2015/03), “MINECO” (SAF2014-52940-R, SAF2017-85199-P and SAF 2016-78666-R), “Comunidadde Madrid” (PEJ-2019-AI/SAL-12877), “Erasmus+ funding programme”, UCM-Santander (PR44/21-29931 to J.A.M.-G.), and partially supported by “Fondo Europeo de Desarrollo Regional” (FEDER) from the European Union.Multidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIIMinisterio de Economía y Competitividad (España)Comunidad de MadridUniversidad Complutense de MadridBanco SantanderEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320222023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/289766reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//SAF2014-52940-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-85199-Pinfo:eu-repo/grantAgreement/MINECO//SAF2016-78666-RS2019/SAL-12877http://dx.doi.org/10.3390/cells11152297Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2897662026-05-22T06:33:51Z
dc.title.none.fl_str_mv Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
title Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
spellingShingle Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
Alarcón-Gil, Jesús
Autophagy
Lipophagy
Neurodegeneration
Lipid droplets
Oxidative Stress
title_short Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
title_full Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
title_fullStr Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
title_full_unstemmed Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
title_sort Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
dc.creator.none.fl_str_mv Alarcón-Gil, Jesús
Sierra-Magro, Ana
Morales-García, José A.
Sanz-SanCristóbal, Marina
Alonso-Gil, Sandra
Cortés-Canteli, Marta
Niso-Santano, Mireia
Martinez-Chacon, Guadalupe
Fuentes, José M.
Santos, Ángel
Pérez-Castillo, Ana
author Alarcón-Gil, Jesús
author_facet Alarcón-Gil, Jesús
Sierra-Magro, Ana
Morales-García, José A.
Sanz-SanCristóbal, Marina
Alonso-Gil, Sandra
Cortés-Canteli, Marta
Niso-Santano, Mireia
Martinez-Chacon, Guadalupe
Fuentes, José M.
Santos, Ángel
Pérez-Castillo, Ana
author_role author
author2 Sierra-Magro, Ana
Morales-García, José A.
Sanz-SanCristóbal, Marina
Alonso-Gil, Sandra
Cortés-Canteli, Marta
Niso-Santano, Mireia
Martinez-Chacon, Guadalupe
Fuentes, José M.
Santos, Ángel
Pérez-Castillo, Ana
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
Universidad Complutense de Madrid
Banco Santander
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Autophagy
Lipophagy
Neurodegeneration
Lipid droplets
Oxidative Stress
topic Autophagy
Lipophagy
Neurodegeneration
Lipid droplets
Oxidative Stress
description Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitochondrial dysfunction, loss of proteostasis, and autophagy impairment. Moreover, in recent years, lipid metabolism alterations have become relevant in PD pathogeny. The modification of lipid metabolism has become a possible way to treat the disease. Because of this, we analyzed the effect and possible mechanism of action of linoleic acid (LA) on an SH-SY5Y PD cell line model and a PD mouse model, both induced by 6-hydroxydopamine (6-OHDA) treatment. The results show that LA acts as a potent neuroprotective and anti-inflammatory agent in these PD models. We also observed that LA stimulates the biogenesis of lipid droplets and improves the autophagy/lipophagy flux, which resulted in an antioxidant effect in the in vitro PD model. In summary, we confirmed the neuroprotective effect of LA in vitro and in vivo against PD. We also obtained some clues about the novel neuroprotective mechanism of LA against PD through the regulation of lipid droplet dynamics.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/289766
url http://hdl.handle.net/10261/289766
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//SAF2014-52940-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-85199-P
info:eu-repo/grantAgreement/MINECO//SAF2016-78666-R
S2019/SAL-12877
http://dx.doi.org/10.3390/cells11152297
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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