Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)

Introduction: The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This...

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Autores: Sánchez Pérez, Belinda, Alcazar López, Cándido F., Serradilla Martín, Mario, Villodres-Tudela, Celia, Hernández, Belén, Santoyo, Julio, Gómez Bravo, Miguel Ángel, Suárez Artacho, Gonzalo, Rubio García, Juan J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/179319
Acceso en línea:https://hdl.handle.net/11441/179319
https://doi.org/10.1016/j.asjsur.2025.04.182
Access Level:acceso abierto
Palabra clave:Left pancreatectomy
Adenocarcinoma
Neuroendocrine tumor
Cystic lesions
Postoperative complication
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spelling Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)Sánchez Pérez, BelindaAlcazar López, Cándido F.Serradilla Martín, MarioVillodres-Tudela, CeliaHernández, BelénSantoyo, JulioGómez Bravo, Miguel ÁngelSuárez Artacho, GonzaloRubio García, Juan J.Left pancreatectomyAdenocarcinomaNeuroendocrine tumorCystic lesionsPostoperative complicationIntroduction: The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This uncertainty raises the question of whether LP presents different morbidity and mortality profiles depending on the neoplasm type, potentially aiding decision-making. Objective: To compare postoperative outcomes by tumor type in a prospective series of LPs in Spain. Methods: The SPANDISPAN Project is a prospective, multicenter, observational study conducted in hepato-pancreato-biliary units from February 2022 to January 2023. A total of 311 patients from 41 Spanish centers participated. Patients were categorized by etiology: Adenocarcinoma (ADC), Intraductal Papillary Mucinous + Mucinous Cystic Neoplasms (IPMN + MCN), Neuroendocrine Tumors (NET), and Others. Pancreatic surgery-specific complications were defined by the International Study Group on Pancreatic Surgery (ISGPS). Results: Postoperative complications were similar overall and for Clavien-Dindo grade > II. No significant differences were observed in POPF, except that grade B/C was more frequent in NET (29.6 %, p < 0.039), mainly due to grade B (53.3 %). No differences were found in PPH or DGE, though the severity of hemorrhage differed significantly (p < 0.035), with grade B more common in Others and grade C in NET (66.7 %). Conclusion: No significant differences in complication rates were found based on etiology. Non-functioning NETs in elderly patients should be carefully assessed due to the increased severity of POPF, PPH, and reoperation rates.ElsevierCirugíaCTS664: Cirugía Avanzada y Trasplantes. Terapia Celular y Bioingeniería Aplicada a la Cirugía2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/179319https://doi.org/10.1016/j.asjsur.2025.04.182reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésAsian Journal of Surgery, 48 (7), 4137-4143.https://www.sciencedirect.com/science/article/pii/S1015958425011480?via%3Dihubinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1793192026-06-17T12:51:07Z
dc.title.none.fl_str_mv Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
title Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
spellingShingle Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
Sánchez Pérez, Belinda
Left pancreatectomy
Adenocarcinoma
Neuroendocrine tumor
Cystic lesions
Postoperative complication
title_short Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
title_full Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
title_fullStr Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
title_full_unstemmed Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
title_sort Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
dc.creator.none.fl_str_mv Sánchez Pérez, Belinda
Alcazar López, Cándido F.
Serradilla Martín, Mario
Villodres-Tudela, Celia
Hernández, Belén
Santoyo, Julio
Gómez Bravo, Miguel Ángel
Suárez Artacho, Gonzalo
Rubio García, Juan J.
author Sánchez Pérez, Belinda
author_facet Sánchez Pérez, Belinda
Alcazar López, Cándido F.
Serradilla Martín, Mario
Villodres-Tudela, Celia
Hernández, Belén
Santoyo, Julio
Gómez Bravo, Miguel Ángel
Suárez Artacho, Gonzalo
Rubio García, Juan J.
author_role author
author2 Alcazar López, Cándido F.
Serradilla Martín, Mario
Villodres-Tudela, Celia
Hernández, Belén
Santoyo, Julio
Gómez Bravo, Miguel Ángel
Suárez Artacho, Gonzalo
Rubio García, Juan J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Cirugía
CTS664: Cirugía Avanzada y Trasplantes. Terapia Celular y Bioingeniería Aplicada a la Cirugía
dc.subject.none.fl_str_mv Left pancreatectomy
Adenocarcinoma
Neuroendocrine tumor
Cystic lesions
Postoperative complication
topic Left pancreatectomy
Adenocarcinoma
Neuroendocrine tumor
Cystic lesions
Postoperative complication
description Introduction: The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This uncertainty raises the question of whether LP presents different morbidity and mortality profiles depending on the neoplasm type, potentially aiding decision-making. Objective: To compare postoperative outcomes by tumor type in a prospective series of LPs in Spain. Methods: The SPANDISPAN Project is a prospective, multicenter, observational study conducted in hepato-pancreato-biliary units from February 2022 to January 2023. A total of 311 patients from 41 Spanish centers participated. Patients were categorized by etiology: Adenocarcinoma (ADC), Intraductal Papillary Mucinous + Mucinous Cystic Neoplasms (IPMN + MCN), Neuroendocrine Tumors (NET), and Others. Pancreatic surgery-specific complications were defined by the International Study Group on Pancreatic Surgery (ISGPS). Results: Postoperative complications were similar overall and for Clavien-Dindo grade > II. No significant differences were observed in POPF, except that grade B/C was more frequent in NET (29.6 %, p < 0.039), mainly due to grade B (53.3 %). No differences were found in PPH or DGE, though the severity of hemorrhage differed significantly (p < 0.035), with grade B more common in Others and grade C in NET (66.7 %). Conclusion: No significant differences in complication rates were found based on etiology. Non-functioning NETs in elderly patients should be carefully assessed due to the increased severity of POPF, PPH, and reoperation rates.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/179319
https://doi.org/10.1016/j.asjsur.2025.04.182
url https://hdl.handle.net/11441/179319
https://doi.org/10.1016/j.asjsur.2025.04.182
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Asian Journal of Surgery, 48 (7), 4137-4143.
https://www.sciencedirect.com/science/article/pii/S1015958425011480?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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