Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?

Microbiota fecal; Microbioma intestinal; Consistencia de las heces

Bibliographic Details
Authors: Vork, Lisa, Penders, John, Jalanka, Jonna, Bojic, Svetlana, van Kuijk, Sander M. J., Salonen, Anne, Pozuelo Del Rio, Marta, Manichanh, Chaysavanh
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7444
Online Access:https://hdl.handle.net/11351/7444
http://hdl.handle.net/11351/7444
Access Level:Open access
Keyword:Còlon irritable
Intestins - Microbiologia
PHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome
DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases, Functional::Irritable Bowel Syndrome
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota::microbiota intestinal
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritable
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
title Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
spellingShingle Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
Vork, Lisa
Còlon irritable
Intestins - Microbiologia
PHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome
DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases, Functional::Irritable Bowel Syndrome
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota::microbiota intestinal
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritable
title_short Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
title_full Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
title_fullStr Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
title_full_unstemmed Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
title_sort Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?
dc.creator.none.fl_str_mv Vork, Lisa
Penders, John
Jalanka, Jonna
Bojic, Svetlana
van Kuijk, Sander M. J.
Salonen, Anne
Pozuelo Del Rio, Marta
Manichanh, Chaysavanh
author Vork, Lisa
author_facet Vork, Lisa
Penders, John
Jalanka, Jonna
Bojic, Svetlana
van Kuijk, Sander M. J.
Salonen, Anne
Pozuelo Del Rio, Marta
Manichanh, Chaysavanh
author_role author
author2 Penders, John
Jalanka, Jonna
Bojic, Svetlana
van Kuijk, Sander M. J.
Salonen, Anne
Pozuelo Del Rio, Marta
Manichanh, Chaysavanh
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Vork L] Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, Netherlands. [Penders J] Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, Netherlands. [Jalanka J, Salonen A] Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. [Bojic S] Department of Biochemical Engineering and Biotechnology, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia. [van Kuijk SMJ] Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, Maastricht, Netherlands. [Pozuelo M] Unitat de Recerca en l’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Manichanh C] Unitat de Recerca en l’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Còlon irritable
Intestins - Microbiologia
PHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome
DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases, Functional::Irritable Bowel Syndrome
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota::microbiota intestinal
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritable
topic Còlon irritable
Intestins - Microbiologia
PHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome
DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases, Functional::Irritable Bowel Syndrome
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota::microbiota intestinal
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritable
description Microbiota fecal; Microbioma intestinal; Consistencia de las heces
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7444
http://hdl.handle.net/11351/7444
url https://hdl.handle.net/11351/7444
http://hdl.handle.net/11351/7444
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in cellular and infection microbiology;11
https://doi.org/10.3389/fcimb.2021.639667
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406086796148736
spelling Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?Vork, LisaPenders, JohnJalanka, JonnaBojic, Svetlanavan Kuijk, Sander M. J.Salonen, AnnePozuelo Del Rio, MartaManichanh, ChaysavanhCòlon irritableIntestins - MicrobiologiaPHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota::Gastrointestinal MicrobiomeDISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases, Functional::Irritable Bowel SyndromeFENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota::microbiota intestinalENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritableMicrobiota fecal; Microbioma intestinal; Consistencia de las hecesMicrobiota fecal; Microbioma intestinal; Consistència de les femtesFecal microbiota; Intestinal microbiome; Stool consistencyIntroduction: Stool consistency has been associated with fecal microbial composition. Stool consistency often varies over time, in subjects with and without gastrointestinal disorders, raising the question whether variability in the microbial composition should be considered in microbiota studies. We evaluated within-subject day-to-day variability in stool consistency and the association with the fecal microbiota in irritable bowel syndrome (IBS) and healthy subjects, over seven days. Methods: Twelve IBS patients and 12 healthy subjects collected fecal samples during seven consecutive days. Stool consistency was determined by the patient-reported Bristol Stool Scale (BSS) and fecal dry weight percentage. 16S rRNA V4 gene sequencing was performed and microbial richness (alpha diversity; Chao1 index, observed number of species, effective Shannon index) and microbial community structure (beta diversity; Bray-Curtis distance, generalized UniFrac, and taxa abundance on family level) were determined. Results: Linear mixed-effects models showed significant associations between stool consistency and microbial richness, but no time effect. This implies that between-subject but not within-subject variation in microbiota over time can partially be explained by variation in stool consistency. Redundancy analysis showed a significant association between stool consistency and microbial community structure, but additional linear mixed-effects models did not demonstrate a time effect on this. Conclusion: This study supports an association between stool consistency and fecal microbiota, but no effect of day-to-day fluctuations in stool consistency within seven days. This consolidates the importance of considering stool consistency in gut microbiota research, though confirms the validity of single fecal sampling to represent an individual’s microbiota at a given time point. NCT00775060.This manuscript results in part from collaboration and network activities promoted under the frame of the international network GENIEUR (Genes in Irritable Bowel Syndrome Research Network Europe), which has been funded by the COST program (BM1106, www.GENIEUR.eu) and is currently supported by the European Society of Neurogastroenterology and Motility (ESNM, www.ESNM.eu).Frontiers MediaInstitut Català de la Salut[Vork L] Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, Netherlands. [Penders J] Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, Netherlands. [Jalanka J, Salonen A] Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. [Bojic S] Department of Biochemical Engineering and Biotechnology, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia. [van Kuijk SMJ] Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, Maastricht, Netherlands. [Pozuelo M] Unitat de Recerca en l’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Manichanh C] Unitat de Recerca en l’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/7444http://hdl.handle.net/11351/7444Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in cellular and infection microbiology;11https://doi.org/10.3389/fcimb.2021.639667Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/74442026-05-29T05:05:01Z
score 15.812455

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