Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems

Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capa...

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Detalhes bibliográficos
Autores: Jichuan, Qiu, Zhang, Ruibin, Li, Jianhua, Sang, Yuanhua, Wei, Tang, Rivera Gil, Pilar, 1976-, Liu, Hong
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2015
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/60729
Acesso em linha:http://hdl.handle.net/10230/60729
http://dx.doi.org/10.2147/IJN.S91864
Access Level:Acceso aberto
Palavra-chave:Controlled release
Drug delivery
Graphene quantum dots
pH-sensitive
Traceable
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spelling Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systemsJichuan, QiuZhang, RuibinLi, JianhuaSang, YuanhuaWei, TangRivera Gil, Pilar, 1976-Liu, HongControlled releaseDrug deliveryGraphene quantum dotspH-sensitiveTraceableGraphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells.Editor de càrrega202420242015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60729http://dx.doi.org/10.2147/IJN.S91864reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInt J Nanomedicine. 2015 Oct 28;10:6709-24© 2015 Qiu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.phphttp://creativecommons.org/licenses/by-nc/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/607292026-05-29T05:05:01Z
dc.title.none.fl_str_mv Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
title Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
spellingShingle Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
Jichuan, Qiu
Controlled release
Drug delivery
Graphene quantum dots
pH-sensitive
Traceable
title_short Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
title_full Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
title_fullStr Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
title_full_unstemmed Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
title_sort Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
dc.creator.none.fl_str_mv Jichuan, Qiu
Zhang, Ruibin
Li, Jianhua
Sang, Yuanhua
Wei, Tang
Rivera Gil, Pilar, 1976-
Liu, Hong
author Jichuan, Qiu
author_facet Jichuan, Qiu
Zhang, Ruibin
Li, Jianhua
Sang, Yuanhua
Wei, Tang
Rivera Gil, Pilar, 1976-
Liu, Hong
author_role author
author2 Zhang, Ruibin
Li, Jianhua
Sang, Yuanhua
Wei, Tang
Rivera Gil, Pilar, 1976-
Liu, Hong
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Controlled release
Drug delivery
Graphene quantum dots
pH-sensitive
Traceable
topic Controlled release
Drug delivery
Graphene quantum dots
pH-sensitive
Traceable
description Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells.
publishDate 2015
dc.date.none.fl_str_mv 2015
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60729
http://dx.doi.org/10.2147/IJN.S91864
url http://hdl.handle.net/10230/60729
http://dx.doi.org/10.2147/IJN.S91864
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Nanomedicine. 2015 Oct 28;10:6709-24
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editor de càrrega
publisher.none.fl_str_mv Editor de càrrega
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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