Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals
Plasma biomarkers for Alzheimer's disease (AD) are a promising tool that may help in early diagnosis. However, their levels may be influenced by physiological parameters and comorbidities that should be considered before they can be used at the population level. For this purpose, we assessed th...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2024 |
| País: | España |
| Recursos: | Universidad de Cantabria (UC) |
| Repositório: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.unican.es:10902/32746 |
| Acesso em linha: | https://hdl.handle.net/10902/32746 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Alzheimer’s disease Plasma biomarkers Presymptomatic stages Comorbidities Amyloid Tau protein |
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Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individualsMartínez Dubarbie, FranciscoGuerra Ruiz, AntonioLópez García, SaraIrure Ventura, JuanLage Martínez, CarmenFernández Matarrubia, MartaPozueta Cantudo, AnaGarcía-Martínez, MariaCorrales Pardo, Andrea|||0000-0001-9616-6985Bravo González, María PazMartín-Arroyo, JuanInfante Ceberio, Jon|||0000-0003-4025-4606López Hoyos, MarcosGarcía Unzueta, María TeresaSánchez-Juan, Pascual|||0000-0002-6081-8037Rodríguez Rodríguez, Eloy ManuelAlzheimer’s diseasePlasma biomarkersPresymptomatic stagesComorbiditiesAmyloidTau proteinPlasma biomarkers for Alzheimer's disease (AD) are a promising tool that may help in early diagnosis. However, their levels may be influenced by physiological parameters and comorbidities that should be considered before they can be used at the population level. For this purpose, we assessed the influences of different comorbidities on AD plasma markers in 208 cognitively unimpaired subjects. We analyzed both plasma and cerebrospinal fluid levels of Aβ40, Aβ42, and p-tau181 using the fully automated Lumipulse platform. The relationships between the different plasma markers and physiological variables were studied using linear regression models. The mean differences in plasma markers according to comorbidity groups were also studied. The glomerular filtration rate showed an influence on plasma Aβ40 and Aβ42 levels but not on the Aβ42/Aβ40 ratio. The amyloid ratio was significantly lower in diabetic and hypertensive subjects, and the mean p-tau181 levels were higher in hypertensive subjects. The glomerular filtration rate may have an inverse relationship on plasma Aβ40 and Aβ42 levels but not on the amyloid ratio, suggesting that the latter is a more stable marker to use in the general population. Cardiovascular risk factors might have a long-term effect on the amyloid ratio and plasma levels of p-tau181.Funding: This research received no external funding. Acknowledgments: This study was made possible thanks to donations from Germán González, Unidos por un Reto, Trail Nocturno de Cicero, La Trasmerana, and Primer Memorial Ángel Negrete. We would like to thank the participants of the Valdecilla Cohort for their selfless help and collaboration with research on neurodegenerative diseases. We would like to particularly acknowledge the patients and the Biobank Valdecilla (PT20/00067) in the Spanish Biobank Network for their collaboration.MDPIUniversidad de Cantabria20242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/32746International Journal of Molecular Sciences, 2024, 25, 1481reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/327462026-06-02T12:39:31Z |
| dc.title.none.fl_str_mv |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals |
| title |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals |
| spellingShingle |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals Martínez Dubarbie, Francisco Alzheimer’s disease Plasma biomarkers Presymptomatic stages Comorbidities Amyloid Tau protein |
| title_short |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals |
| title_full |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals |
| title_fullStr |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals |
| title_full_unstemmed |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals |
| title_sort |
Influence of physiological variables and comorbidities on plasma Aβ40, Aβ42, and p-tau181 levels in cognitively unimpaired individuals |
| dc.creator.none.fl_str_mv |
Martínez Dubarbie, Francisco Guerra Ruiz, Antonio López García, Sara Irure Ventura, Juan Lage Martínez, Carmen Fernández Matarrubia, Marta Pozueta Cantudo, Ana García-Martínez, Maria Corrales Pardo, Andrea|||0000-0001-9616-6985 Bravo González, María Paz Martín-Arroyo, Juan Infante Ceberio, Jon|||0000-0003-4025-4606 López Hoyos, Marcos García Unzueta, María Teresa Sánchez-Juan, Pascual|||0000-0002-6081-8037 Rodríguez Rodríguez, Eloy Manuel |
| author |
Martínez Dubarbie, Francisco |
| author_facet |
Martínez Dubarbie, Francisco Guerra Ruiz, Antonio López García, Sara Irure Ventura, Juan Lage Martínez, Carmen Fernández Matarrubia, Marta Pozueta Cantudo, Ana García-Martínez, Maria Corrales Pardo, Andrea|||0000-0001-9616-6985 Bravo González, María Paz Martín-Arroyo, Juan Infante Ceberio, Jon|||0000-0003-4025-4606 López Hoyos, Marcos García Unzueta, María Teresa Sánchez-Juan, Pascual|||0000-0002-6081-8037 Rodríguez Rodríguez, Eloy Manuel |
| author_role |
author |
| author2 |
Guerra Ruiz, Antonio López García, Sara Irure Ventura, Juan Lage Martínez, Carmen Fernández Matarrubia, Marta Pozueta Cantudo, Ana García-Martínez, Maria Corrales Pardo, Andrea|||0000-0001-9616-6985 Bravo González, María Paz Martín-Arroyo, Juan Infante Ceberio, Jon|||0000-0003-4025-4606 López Hoyos, Marcos García Unzueta, María Teresa Sánchez-Juan, Pascual|||0000-0002-6081-8037 Rodríguez Rodríguez, Eloy Manuel |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Alzheimer’s disease Plasma biomarkers Presymptomatic stages Comorbidities Amyloid Tau protein |
| topic |
Alzheimer’s disease Plasma biomarkers Presymptomatic stages Comorbidities Amyloid Tau protein |
| description |
Plasma biomarkers for Alzheimer's disease (AD) are a promising tool that may help in early diagnosis. However, their levels may be influenced by physiological parameters and comorbidities that should be considered before they can be used at the population level. For this purpose, we assessed the influences of different comorbidities on AD plasma markers in 208 cognitively unimpaired subjects. We analyzed both plasma and cerebrospinal fluid levels of Aβ40, Aβ42, and p-tau181 using the fully automated Lumipulse platform. The relationships between the different plasma markers and physiological variables were studied using linear regression models. The mean differences in plasma markers according to comorbidity groups were also studied. The glomerular filtration rate showed an influence on plasma Aβ40 and Aβ42 levels but not on the Aβ42/Aβ40 ratio. The amyloid ratio was significantly lower in diabetic and hypertensive subjects, and the mean p-tau181 levels were higher in hypertensive subjects. The glomerular filtration rate may have an inverse relationship on plasma Aβ40 and Aβ42 levels but not on the amyloid ratio, suggesting that the latter is a more stable marker to use in the general population. Cardiovascular risk factors might have a long-term effect on the amyloid ratio and plasma levels of p-tau181. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10902/32746 |
| url |
https://hdl.handle.net/10902/32746 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
| dc.source.none.fl_str_mv |
International Journal of Molecular Sciences, 2024, 25, 1481 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
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Universidad de Cantabria (UC) |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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15.198674 |