Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts

Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer's disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do not fully reflect the patient landscape found in clinical settings. Therefore, in this multicentre st...

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Detalles Bibliográficos
Autores: Lantero Rodríguez, Juan|||0000-0002-7426-678X, Vrillon, Agathe, Fernández-Lebrero, Aida|||0000-0002-2097-4430, Ortiz-Romero, Paula|||0000-0002-6378-6763, Snellman, Anniina, Montoliu Gaya, Laia|||0000-0001-7684-6318, Brum, Wagner S., Cognat, Emmanuel, Dumurgier, Julien, Puig-Pijoan, Albert|||0000-0002-9848-3711, Navalpotro-Gómez, Irene, García-Escobar, Greta, Karikari, Thomas K.|||0000-0003-1422-4358, Vanmechelen, Eugeen|||0000-0002-9466-5366, Ashton, Nicholas J.|||0000-0002-3579-8804, Zetterberg, Henrik|||0000-0003-3930-4354, Suárez-Calvet, Marc|||0000-0002-2993-569X, Paquet, Claire|||0000-0002-2273-7316, Blennow, Kaj|||0000-0002-1890-4193
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:273221
Acceso en línea:https://ddd.uab.cat/record/273221
https://dx.doi.org/urn:doi:10.1186/s13195-023-01201-0
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
CSF
Biomarkers
P-tau235
P-tau181
P-tau217
P-tau231
Memory clinic
Descripción
Sumario:Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer's disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do not fully reflect the patient landscape found in clinical settings. Therefore, in this multicentre study, we investigated the performance of CSF p-tau235 to detect symptomatic AD in clinical settings and compared it with CSF p-tau181, p-tau217 and p-tau231. CSF p-tau235 was measured using an in-house single molecule array (Simoa) assay in two independent memory clinic cohorts: Paris cohort (Lariboisière Fernand-Widal University Hospital Paris, France; n.

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