Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial

Aims Iron deficiency (ID) is associated with an impaired cardiac function and remodelling in heart failure (HF). Treatment with ferric carboxymaltose (FCM) has been showed recently to improve biventricular systolic function and ventricular strain parameters in patients with HF with reduced ejection...

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Autores: Santas, E, Del Canto, I, Cardells, I, Miñana, G, Llácer, P, Almenar, L, Fácila, L, Maceira, AM, Sanchis, J, Núñez, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17892
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/17892
Access Level:acceso abierto
Palabra clave:Heart failure
Iron deficiency
Ferric carboxymaltose
Cardiovascular magnetic resonance
Feature tracking
Left atrial
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spelling Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trialSantas, EDel Canto, ICardells, IMiñana, GLlácer, PAlmenar, LFácila, LMaceira, AMSanchis, JNúñez, JHeart failureIron deficiencyFerric carboxymaltoseCardiovascular magnetic resonanceFeature trackingLeft atrialAims Iron deficiency (ID) is associated with an impaired cardiac function and remodelling in heart failure (HF). Treatment with ferric carboxymaltose (FCM) has been showed recently to improve biventricular systolic function and ventricular strain parameters in patients with HF with reduced ejection fraction and ID, but there is no evidence on the benefit of FCM on the left atrium (LA). In this study, we aimed to evaluate the effect of FCM on LA longitudinal strain (LA-LS).Methods and results This is a post hoc subanalysis of a double-blind, placebo-controlled, randomized clinical trial that enrolled 53 ambulatory patients with HF, left ventricular ejection fraction (LVEF) < 50%, and ID [Myocardial-IRON trial (NCT03398681)], treated with FCM or placebo. Cardiac magnetic resonance-featured tracking (CMR-FT) strain changes were evaluated before and 7 and 30 days after randomization using linear mixed regression analysis. The median age of the sample was 68 years (interquartile range: 64-76), and 20 (69%) were men. Mean +/- standard deviation of LVEF was 39 +/- 11%, and most (97%) were in stable New York Heart Association class II. At baseline, mean LA-LS was -8.9 +/- 3.5%. At 30 days, and compared with placebo, LA-LS significantly improved in those allocated to FCM treatment arm (LA-LS = -12.0 +/- 0.5 and -8.5 +/- 0.6, respectively; - triangle 3.55%, P < 0.001).Conclusions In patients with stable HF, LVEF < 50%, and ID, treatment with FCM was associated with short-term improvements in LA-LS assessed by CMR-FT. Future works should assess the potential benefit of iron repletion on LA function.WILEY PERIODICALS, INC2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17892ESC Heart FailureISSN: 20555822reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p178922026-06-07T16:35:31Z
dc.title.none.fl_str_mv Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
title Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
spellingShingle Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
Santas, E
Heart failure
Iron deficiency
Ferric carboxymaltose
Cardiovascular magnetic resonance
Feature tracking
Left atrial
title_short Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
title_full Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
title_fullStr Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
title_full_unstemmed Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
title_sort Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial
dc.creator.none.fl_str_mv Santas, E
Del Canto, I
Cardells, I
Miñana, G
Llácer, P
Almenar, L
Fácila, L
Maceira, AM
Sanchis, J
Núñez, J
author Santas, E
author_facet Santas, E
Del Canto, I
Cardells, I
Miñana, G
Llácer, P
Almenar, L
Fácila, L
Maceira, AM
Sanchis, J
Núñez, J
author_role author
author2 Del Canto, I
Cardells, I
Miñana, G
Llácer, P
Almenar, L
Fácila, L
Maceira, AM
Sanchis, J
Núñez, J
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Heart failure
Iron deficiency
Ferric carboxymaltose
Cardiovascular magnetic resonance
Feature tracking
Left atrial
topic Heart failure
Iron deficiency
Ferric carboxymaltose
Cardiovascular magnetic resonance
Feature tracking
Left atrial
description Aims Iron deficiency (ID) is associated with an impaired cardiac function and remodelling in heart failure (HF). Treatment with ferric carboxymaltose (FCM) has been showed recently to improve biventricular systolic function and ventricular strain parameters in patients with HF with reduced ejection fraction and ID, but there is no evidence on the benefit of FCM on the left atrium (LA). In this study, we aimed to evaluate the effect of FCM on LA longitudinal strain (LA-LS).Methods and results This is a post hoc subanalysis of a double-blind, placebo-controlled, randomized clinical trial that enrolled 53 ambulatory patients with HF, left ventricular ejection fraction (LVEF) < 50%, and ID [Myocardial-IRON trial (NCT03398681)], treated with FCM or placebo. Cardiac magnetic resonance-featured tracking (CMR-FT) strain changes were evaluated before and 7 and 30 days after randomization using linear mixed regression analysis. The median age of the sample was 68 years (interquartile range: 64-76), and 20 (69%) were men. Mean +/- standard deviation of LVEF was 39 +/- 11%, and most (97%) were in stable New York Heart Association class II. At baseline, mean LA-LS was -8.9 +/- 3.5%. At 30 days, and compared with placebo, LA-LS significantly improved in those allocated to FCM treatment arm (LA-LS = -12.0 +/- 0.5 and -8.5 +/- 0.6, respectively; - triangle 3.55%, P < 0.001).Conclusions In patients with stable HF, LVEF < 50%, and ID, treatment with FCM was associated with short-term improvements in LA-LS assessed by CMR-FT. Future works should assess the potential benefit of iron repletion on LA function.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/17892
url https://incliva.portalinvestigacion.com/publicaciones/17892
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY PERIODICALS, INC
publisher.none.fl_str_mv WILEY PERIODICALS, INC
dc.source.none.fl_str_mv ESC Heart Failure
ISSN: 20555822
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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