Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts

The “primary” or “first-order relay” nuclei of the thalamus feed the cerebral cortex with information about ongoing activity in the environment or the subcortical motor systems. Because of the small size of these nuclei and the high specificity of their input and output pathways, new imaging protoco...

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Autores: Liu, Mengxing, Lerma-Usabiaga, Garikoitz, Clasca Cabre, Francisco, Paz-Alonso, Pedro M.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/708373
Acceso en línea:http://hdl.handle.net/10486/708373
https://dx.doi.org/10.1016/j.neuroimage.2022.119558
Access Level:acceso abierto
Palabra clave:thalamus
thalamocortica
cerebellum
diffusion MRI
tractography
reproducibility
Medicina
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spelling Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tractsLiu, MengxingLerma-Usabiaga, GarikoitzClasca Cabre, FranciscoPaz-Alonso, Pedro M.thalamusthalamocorticacerebellumdiffusion MRItractographyreproducibilityMedicinaThe “primary” or “first-order relay” nuclei of the thalamus feed the cerebral cortex with information about ongoing activity in the environment or the subcortical motor systems. Because of the small size of these nuclei and the high specificity of their input and output pathways, new imaging protocols are required to investigate thalamocortical interactions in human perception, cognition and language. The goal of the present study was twofold: I) to develop a reconstruction protocol based on in vivo diffusion MRI to extract and measure the axonal fiber tracts that originate or terminate specifically in individual first-order relay nuclei; and, II) to test the reliability of this reconstruction protocol. In left and right hemispheres, we investigated the thalamocortical/corticothalamic axon bundles linking each of the first-order relay nuclei and their main cortical target areas, namely, the lateral geniculate nucleus (optic radiation), the medial geniculate nucleus (acoustic radiation), the ventral posterior nucleus (somatosensory radiation) and the ventral lateral nucleus (motor radiation). In addition, we examined the main subcortical input pathway to the ventral lateral posterior nucleus, which originates in the dentate nucleus of the cerebellum. Our protocol comprised three components: defining regions-of-interest; preprocessing diffusion data; and modeling white-matter tracts and tractometry. We then used computation and test-retest methods to check whether our protocol could reliably reconstruct these tracts of interest and their profiles. Our results demonstrated that the protocol had nearly perfect computational reproducibility and good-to-excellent test-retest reproducibility. This new protocol may be of interest for both basic human brain neuroscience and clinical studies and has been made publicly available to the scientific communityWe thank David Carcedo for helping with data collection and Magda Altman and Caroline Handley for helping with manuscript proofreading. This work was supported by grants from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie (grant agreement No. 713673), and from “la Caixa” Foundation (grant No. 11660016) to M.L.; grants from the Spanish Ministerio de Ciencia e Innovación (IJC2020-042887-I; PID2021- 123577NA-I00) to G.L.-U.; grants from the European Union’s Horizon 2020 Research and Innovation Program, European Commission (grant agreement No. 945539 - HBP SGA3) and from the Ministerio de Ciencia e Innovación FLAG-ERA grant NeuronsReunited (MICINN-AEI PCI2019-1119002) to F.C.; and grants from the Ministerio de Ciencia e Innovación (PGC2018-093408-B-I00; PID2021-123574NB-I00), Neuroscience projects from the Fundación Tatiana Pérez de Guzmán el Bueno, Basque Government (PIBA-2021-1-0003), and a grant from “la Caixa” Banking Foundation under the project code LCF/PR/HR19/52160002 to P.M.P.-A. BCBL acknowledges support by the Basque Government through the BERC 2022-2025 program and by the Spanish State Research Agency through BCBL Severo Ochoa excellence accreditation CEX2020-001010-SElsevier BVDepartamento de Anatomía, Histología y NeurocienciaFacultad de Medicina20222022-08-11research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/708373https://dx.doi.org/10.1016/j.neuroimage.2022.119558reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 713673open accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7083732026-06-23T12:46:27Z
dc.title.none.fl_str_mv Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
title Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
spellingShingle Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
Liu, Mengxing
thalamus
thalamocortica
cerebellum
diffusion MRI
tractography
reproducibility
Medicina
title_short Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
title_full Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
title_fullStr Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
title_full_unstemmed Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
title_sort Reproducible protocol to obtain and measure first-order relay human thalamic white-matter tracts
dc.creator.none.fl_str_mv Liu, Mengxing
Lerma-Usabiaga, Garikoitz
Clasca Cabre, Francisco
Paz-Alonso, Pedro M.
author Liu, Mengxing
author_facet Liu, Mengxing
Lerma-Usabiaga, Garikoitz
Clasca Cabre, Francisco
Paz-Alonso, Pedro M.
author_role author
author2 Lerma-Usabiaga, Garikoitz
Clasca Cabre, Francisco
Paz-Alonso, Pedro M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Anatomía, Histología y Neurociencia
Facultad de Medicina
dc.subject.none.fl_str_mv thalamus
thalamocortica
cerebellum
diffusion MRI
tractography
reproducibility
Medicina
topic thalamus
thalamocortica
cerebellum
diffusion MRI
tractography
reproducibility
Medicina
description The “primary” or “first-order relay” nuclei of the thalamus feed the cerebral cortex with information about ongoing activity in the environment or the subcortical motor systems. Because of the small size of these nuclei and the high specificity of their input and output pathways, new imaging protocols are required to investigate thalamocortical interactions in human perception, cognition and language. The goal of the present study was twofold: I) to develop a reconstruction protocol based on in vivo diffusion MRI to extract and measure the axonal fiber tracts that originate or terminate specifically in individual first-order relay nuclei; and, II) to test the reliability of this reconstruction protocol. In left and right hemispheres, we investigated the thalamocortical/corticothalamic axon bundles linking each of the first-order relay nuclei and their main cortical target areas, namely, the lateral geniculate nucleus (optic radiation), the medial geniculate nucleus (acoustic radiation), the ventral posterior nucleus (somatosensory radiation) and the ventral lateral nucleus (motor radiation). In addition, we examined the main subcortical input pathway to the ventral lateral posterior nucleus, which originates in the dentate nucleus of the cerebellum. Our protocol comprised three components: defining regions-of-interest; preprocessing diffusion data; and modeling white-matter tracts and tractometry. We then used computation and test-retest methods to check whether our protocol could reliably reconstruct these tracts of interest and their profiles. Our results demonstrated that the protocol had nearly perfect computational reproducibility and good-to-excellent test-retest reproducibility. This new protocol may be of interest for both basic human brain neuroscience and clinical studies and has been made publicly available to the scientific community
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-11
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/708373
https://dx.doi.org/10.1016/j.neuroimage.2022.119558
url http://hdl.handle.net/10486/708373
https://dx.doi.org/10.1016/j.neuroimage.2022.119558
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 713673
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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