Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study

Background Telomere length (TL) has been reported to be associated with conditions such as endometriosis and polycystic ovary syndrome, with some studies finding associations with shorter TL and others with longer TL. In men, studies mostly report associations between shorter TL and sperm quality. T...

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Detalhes bibliográficos
Autores: Skåra, Karoline Hansen, Lee, Yunsung, Jugessur, Astanand, Gjessing, Håkon K., Aviv, Abraham, Brumpton, Ben, Næss, Øyvind, Hernáez, Álvaro, Hanevik, Hans Ivar, Magnus, Per, Magnus, Maria Christine
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/5135
Acesso em linha:http://hdl.handle.net/20.500.14342/5135
https://doi.org/10.1186/s12916-024-03795-0
Access Level:acceso abierto
Palavra-chave:Reproducció assistida
Fecunditat
Esterilitat
Aleatorització Mendeliana
MoBa
MRBN
Telòmer
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spelling Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort studySkåra, Karoline HansenLee, YunsungJugessur, AstanandGjessing, Håkon K.Aviv, AbrahamBrumpton, BenNæss, ØyvindHernáez, ÁlvaroHanevik, Hans IvarMagnus, PerMagnus, Maria ChristineReproducció assistidaFecunditatEsterilitatAleatorització MendelianaMoBaMRBNTelòmerBackground Telomere length (TL) has been reported to be associated with conditions such as endometriosis and polycystic ovary syndrome, with some studies finding associations with shorter TL and others with longer TL. In men, studies mostly report associations between shorter TL and sperm quality. To our knowledge, no studies have thus far investigated associations between TL and fecundability or the use of assisted reproductive technologies (ART). Methods This study is based on the Norwegian Mother, Father, and Child Cohort (MoBa) Study and uses data from the Medical Birth Registry of Norway (MBRN). We included women (24,645 with genotype data and 1054 with TL measurements) and men (18,339 with genotype data and 965 with TL measurements) participating between 1998 and 2008. We investigated associations between leukocyte TL (LTL) and fecundability (defined as the probability to conceive within a given menstrual cycle), infertility (defined has having spent 12 months or more trying to conceive without success), and ART use. We also repeated the analyses using instrumental variables for LTL consisting of genetic risk scores for LTL and genetically predicted LTL. Results Approximately 11% of couples had experienced infertility and 4% had used ART. LTL was not associated with fecundability in women (fecundability ratio [FR], 0.98; 95% confidence interval [CI], 0.92–1.04) or men (FR, 0.99; CI, 0.93–1.06), nor with infertility in women (odds ratio [OR], 1.03; CI, 0.85–1.24) or men (OR, 1.05; CI, 0.87–1.28). We observed an increased likelihood of using ART with increasing LTL in men (OR, 1.22; CI, 1.03–1.46), but not in women (OR, 1.10; CI, 0.92–1.31). No significant associations were observed using the instrumental variables for LTL. Conclusions We found no indication that LTL is a suitable biomarker for assessing fecundability, infertility, or ART use. Additional studies are required to replicate the association observed between LTL and ART use in men.info:eu-repo/semantics/publishedVersionBioMed CentralUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna2024info:eu-repo/semantics/article12 p.http://hdl.handle.net/20.500.14342/5135https://doi.org/10.1186/s12916-024-03795-0reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBMC Medicine, 2024, 22: 580info:eu-repo/grantAgreement/EU/H2020/Grant agreement 947684© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/51352026-05-29T05:05:01Z
dc.title.none.fl_str_mv Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
title Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
spellingShingle Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
Skåra, Karoline Hansen
Reproducció assistida
Fecunditat
Esterilitat
Aleatorització Mendeliana
MoBa
MRBN
Telòmer
title_short Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
title_full Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
title_fullStr Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
title_full_unstemmed Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
title_sort Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
dc.creator.none.fl_str_mv Skåra, Karoline Hansen
Lee, Yunsung
Jugessur, Astanand
Gjessing, Håkon K.
Aviv, Abraham
Brumpton, Ben
Næss, Øyvind
Hernáez, Álvaro
Hanevik, Hans Ivar
Magnus, Per
Magnus, Maria Christine
author Skåra, Karoline Hansen
author_facet Skåra, Karoline Hansen
Lee, Yunsung
Jugessur, Astanand
Gjessing, Håkon K.
Aviv, Abraham
Brumpton, Ben
Næss, Øyvind
Hernáez, Álvaro
Hanevik, Hans Ivar
Magnus, Per
Magnus, Maria Christine
author_role author
author2 Lee, Yunsung
Jugessur, Astanand
Gjessing, Håkon K.
Aviv, Abraham
Brumpton, Ben
Næss, Øyvind
Hernáez, Álvaro
Hanevik, Hans Ivar
Magnus, Per
Magnus, Maria Christine
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv Reproducció assistida
Fecunditat
Esterilitat
Aleatorització Mendeliana
MoBa
MRBN
Telòmer
topic Reproducció assistida
Fecunditat
Esterilitat
Aleatorització Mendeliana
MoBa
MRBN
Telòmer
description Background Telomere length (TL) has been reported to be associated with conditions such as endometriosis and polycystic ovary syndrome, with some studies finding associations with shorter TL and others with longer TL. In men, studies mostly report associations between shorter TL and sperm quality. To our knowledge, no studies have thus far investigated associations between TL and fecundability or the use of assisted reproductive technologies (ART). Methods This study is based on the Norwegian Mother, Father, and Child Cohort (MoBa) Study and uses data from the Medical Birth Registry of Norway (MBRN). We included women (24,645 with genotype data and 1054 with TL measurements) and men (18,339 with genotype data and 965 with TL measurements) participating between 1998 and 2008. We investigated associations between leukocyte TL (LTL) and fecundability (defined as the probability to conceive within a given menstrual cycle), infertility (defined has having spent 12 months or more trying to conceive without success), and ART use. We also repeated the analyses using instrumental variables for LTL consisting of genetic risk scores for LTL and genetically predicted LTL. Results Approximately 11% of couples had experienced infertility and 4% had used ART. LTL was not associated with fecundability in women (fecundability ratio [FR], 0.98; 95% confidence interval [CI], 0.92–1.04) or men (FR, 0.99; CI, 0.93–1.06), nor with infertility in women (odds ratio [OR], 1.03; CI, 0.85–1.24) or men (OR, 1.05; CI, 0.87–1.28). We observed an increased likelihood of using ART with increasing LTL in men (OR, 1.22; CI, 1.03–1.46), but not in women (OR, 1.10; CI, 0.92–1.31). No significant associations were observed using the instrumental variables for LTL. Conclusions We found no indication that LTL is a suitable biomarker for assessing fecundability, infertility, or ART use. Additional studies are required to replicate the association observed between LTL and ART use in men.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5135
https://doi.org/10.1186/s12916-024-03795-0
url http://hdl.handle.net/20.500.14342/5135
https://doi.org/10.1186/s12916-024-03795-0
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BMC Medicine, 2024, 22: 580
info:eu-repo/grantAgreement/EU/H2020/Grant agreement 947684
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405763246489600
score 15,812455

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