Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats

A principal animal paradigm employed in Anorexia Nervosa (AN) study is the activity-based anorexia (ABA) model. The model's efficacy in recapitulating the core features of AN in humans allows for the study of the parameters involved in the disorder. The current study examined the susceptibility...

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Autores: Kojo Morgan, Godstime Stephen, Mata, Yolanda, Carrillo Urbano, Beatriz, Pellón Suárez de Puga, Ricardo, Collado Guirao, Paloma, Gotti, Stefano, Pinos Sánchez, María Elena
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Nacional de Educación a Distancia
Repositorio:e-spacio. Repositorio Institucional de la UNED
Idioma:español
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/25128
Acceso en línea:https://hdl.handle.net/20.500.14468/25128
Access Level:acceso abierto
Palabra clave:61 Psicología
Maternal separation
anorexia nervosa
activity-based anorexia
food anticipatory activity
sex differences
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spelling Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley ratsKojo Morgan, Godstime StephenMata, YolandaCarrillo Urbano, BeatrizPellón Suárez de Puga, RicardoCollado Guirao, PalomaGotti, StefanoPinos Sánchez, María Elena61 PsicologíaMaternal separationanorexia nervosaactivity-based anorexiafood anticipatory activitysex differencesA principal animal paradigm employed in Anorexia Nervosa (AN) study is the activity-based anorexia (ABA) model. The model's efficacy in recapitulating the core features of AN in humans allows for the study of the parameters involved in the disorder. The current study examined the susceptibility to the ABA protocol in the presence of a significant stressor (maternal separation) in male and female Sprague Dawley rats. More importantly, we analysed the sex-differences on activity levels during different periods of the ABA protocol to determine the period(s) influencing the most pathological weight loss. Both components of the ABA protocol contributed to the subjects’ bodyweight loss. Stress in the first two weeks of development conferred a protective effect in males. Time spent and activity levels on the running wheel were higher in females compared to males. Hyperactivity in ABA subjects was observed during the food-anticipatory activity (FAA) and postprandial activity in males and during the FAA and nocturnal activity periods in females. This study aids in understanding the effect of intensity of activity during specific periods on the pathological weight loss in ABA rats. These observations are informative for therapies aimed at ameliorating body mass index in AN patients.Elseviere-Spacio UNED20252025-01-0820222022-11-0120222022-11-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/25128reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/251282026-06-06T12:38:31Z
dc.title.none.fl_str_mv Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
title Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
spellingShingle Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
Kojo Morgan, Godstime Stephen
61 Psicología
Maternal separation
anorexia nervosa
activity-based anorexia
food anticipatory activity
sex differences
title_short Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
title_full Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
title_fullStr Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
title_full_unstemmed Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
title_sort Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats
dc.creator.none.fl_str_mv Kojo Morgan, Godstime Stephen
Mata, Yolanda
Carrillo Urbano, Beatriz
Pellón Suárez de Puga, Ricardo
Collado Guirao, Paloma
Gotti, Stefano
Pinos Sánchez, María Elena
author Kojo Morgan, Godstime Stephen
author_facet Kojo Morgan, Godstime Stephen
Mata, Yolanda
Carrillo Urbano, Beatriz
Pellón Suárez de Puga, Ricardo
Collado Guirao, Paloma
Gotti, Stefano
Pinos Sánchez, María Elena
author_role author
author2 Mata, Yolanda
Carrillo Urbano, Beatriz
Pellón Suárez de Puga, Ricardo
Collado Guirao, Paloma
Gotti, Stefano
Pinos Sánchez, María Elena
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv e-Spacio UNED
dc.subject.none.fl_str_mv 61 Psicología
Maternal separation
anorexia nervosa
activity-based anorexia
food anticipatory activity
sex differences
topic 61 Psicología
Maternal separation
anorexia nervosa
activity-based anorexia
food anticipatory activity
sex differences
description A principal animal paradigm employed in Anorexia Nervosa (AN) study is the activity-based anorexia (ABA) model. The model's efficacy in recapitulating the core features of AN in humans allows for the study of the parameters involved in the disorder. The current study examined the susceptibility to the ABA protocol in the presence of a significant stressor (maternal separation) in male and female Sprague Dawley rats. More importantly, we analysed the sex-differences on activity levels during different periods of the ABA protocol to determine the period(s) influencing the most pathological weight loss. Both components of the ABA protocol contributed to the subjects’ bodyweight loss. Stress in the first two weeks of development conferred a protective effect in males. Time spent and activity levels on the running wheel were higher in females compared to males. Hyperactivity in ABA subjects was observed during the food-anticipatory activity (FAA) and postprandial activity in males and during the FAA and nocturnal activity periods in females. This study aids in understanding the effect of intensity of activity during specific periods on the pathological weight loss in ABA rats. These observations are informative for therapies aimed at ameliorating body mass index in AN patients.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-11-01
2022
2022-11-01
2025
2025-01-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/25128
url https://hdl.handle.net/20.500.14468/25128
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e-spacio. Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio. Repositorio Institucional de la UNED
collection e-spacio. Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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