The Value of In Vitro Tests to DiminishDrug Challenges.
Drug hypersensitivity reactions have multiple implications for patient safety and health system costs, thus it is important to perform an accurate diagnosis. The diagnostic procedure includes a detailed clinical history, often unreliable; followed by skin tests, sometimes with low sensitivity or una...
| Authors: | , , , , |
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| Format: | article |
| Publication Date: | 2017 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/17316 |
| Online Access: | http://hdl.handle.net/20.500.12105/17316 |
| Access Level: | Open access |
| Keyword: | IgE T-cells allergy basophils cytokines diagnosis drug hypersensitivity immunoassays in vitro Diagnostic Tests, Routine Drug Hypersensitivity Humans Hypersensitivity, Delayed Hypersensitivity, Immediate Immunoglobulin E T-Lymphocytes |
| Summary: | Drug hypersensitivity reactions have multiple implications for patient safety and health system costs, thus it is important to perform an accurate diagnosis. The diagnostic procedure includes a detailed clinical history, often unreliable; followed by skin tests, sometimes with low sensitivity or unavailable; and drug provocation testing, which is not risk-free for the patient, especially in severe reactions. In vitro tests could help to identify correctly the responsible agent, thus improving the diagnosis of these reactions, helping the physician to find safe alternatives, and reducing the need to perform drug provocation testing. However, it is necessary to confirm the sensitivity, specificity, negative and positive predictive values for these in vitro tests to enable their implementation in clinical practice. In this review, we have analyzed these parameters from different studies that have used in vitro test for evaluating drug hypersensitivity reactions and estimated the added value of these tests to the in vivo diagnosis. |
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