Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications
[EN] Acoustic wave resonators have become suitable devices for a broad range of sensing applications due to their sensitivity, low cost, and integration capability, which are all factors that meet the requirements for the resonators to be used as sensing elements for portable point of care (PoC) pla...
| Autores: | , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/148911 |
| Acesso em linha: | https://riunet.upv.es/handle/10251/148911 |
| Access Level: | acceso abierto |
| Palavra-chave: | HFF-QCM(high fundamental frequency quartz crystalmicrobalance) Finite elementmethod (FEM) Flow cell,biosensor PoC (point of care) MQCM(monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
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Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing ApplicationsFERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653García Narbón, José Vicente|||0000-0001-6303-8258Jiménez Jiménez, Yolanda|||0000-0003-4835-9007Arnau Vives, Antonio|||0000-0002-5709-1690García Molla, PabloGarcía, MaríaHFF-QCM(high fundamental frequency quartz crystalmicrobalance)Finite elementmethod (FEM)Flow cell,biosensorPoC (point of care)MQCM(monolithic quartz crystal microbalance)TECNOLOGIA ELECTRONICA[EN] Acoustic wave resonators have become suitable devices for a broad range of sensing applications due to their sensitivity, low cost, and integration capability, which are all factors that meet the requirements for the resonators to be used as sensing elements for portable point of care (PoC) platforms. In this work, the design, characterization, and validation of a 150 MHz high fundamental frequency quartz crystal microbalance (HFF-QCM) sensor for bio-sensing applications are introduced. Finite element method (FEM) simulations of the proposed design are in good agreement with the electrical characterization of the manufactured resonators. The sensor is also validated for bio-sensing applications. For this purpose, a specific sensor cell was designed and manufactured that addresses the critical requirements associated with this type of sensor and application. Due to the small sensing area and the sensor's fragility, these requirements include a low-volume flow chamber in the nanoliter range, and a system approach that provides the appropriate pressure control for assuring liquid confinement while maintaining the integrity of the sensor with a good base line stability and easy sensor replacement. The sensor characteristics make it suitable for consideration as the elemental part of a sensor matrix in a multichannel platform for point of care applications.This work was funded by the European Commission Horizon 2020 Programme under Grant Agreement number ICT-28-2015/687785-LIQBIOPSENS (Reliable Liquid Biopsy technology for early detection of colorectal cancer).MDPI AGDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería de TelecomunicaciónEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialCentro de Investigación e Innovación en BioingenieríaRepositorio Institucional de la Universitat Politècnica de València Riunet20172017-09-08journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/148911reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengEuropean Commission https://doi.org/10.13039/501100000780 H2020 687785 Reliable Novel Liquid Biopsy technology for early detection of colorectal canceropen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1489112026-06-13T07:49:27Z |
| dc.title.none.fl_str_mv |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications |
| title |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications |
| spellingShingle |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 HFF-QCM(high fundamental frequency quartz crystalmicrobalance) Finite elementmethod (FEM) Flow cell,biosensor PoC (point of care) MQCM(monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
| title_short |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications |
| title_full |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications |
| title_fullStr |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications |
| title_full_unstemmed |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications |
| title_sort |
Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications |
| dc.creator.none.fl_str_mv |
FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 García Narbón, José Vicente|||0000-0001-6303-8258 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 Arnau Vives, Antonio|||0000-0002-5709-1690 García Molla, Pablo García, María |
| author |
FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 |
| author_facet |
FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 García Narbón, José Vicente|||0000-0001-6303-8258 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 Arnau Vives, Antonio|||0000-0002-5709-1690 García Molla, Pablo García, María |
| author_role |
author |
| author2 |
García Narbón, José Vicente|||0000-0001-6303-8258 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 Arnau Vives, Antonio|||0000-0002-5709-1690 García Molla, Pablo García, María |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Ingeniería Electrónica Escuela Técnica Superior de Ingeniería de Telecomunicación Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial Centro de Investigación e Innovación en Bioingeniería Repositorio Institucional de la Universitat Politècnica de València Riunet |
| dc.subject.none.fl_str_mv |
HFF-QCM(high fundamental frequency quartz crystalmicrobalance) Finite elementmethod (FEM) Flow cell,biosensor PoC (point of care) MQCM(monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
| topic |
HFF-QCM(high fundamental frequency quartz crystalmicrobalance) Finite elementmethod (FEM) Flow cell,biosensor PoC (point of care) MQCM(monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
| description |
[EN] Acoustic wave resonators have become suitable devices for a broad range of sensing applications due to their sensitivity, low cost, and integration capability, which are all factors that meet the requirements for the resonators to be used as sensing elements for portable point of care (PoC) platforms. In this work, the design, characterization, and validation of a 150 MHz high fundamental frequency quartz crystal microbalance (HFF-QCM) sensor for bio-sensing applications are introduced. Finite element method (FEM) simulations of the proposed design are in good agreement with the electrical characterization of the manufactured resonators. The sensor is also validated for bio-sensing applications. For this purpose, a specific sensor cell was designed and manufactured that addresses the critical requirements associated with this type of sensor and application. Due to the small sensing area and the sensor's fragility, these requirements include a low-volume flow chamber in the nanoliter range, and a system approach that provides the appropriate pressure control for assuring liquid confinement while maintaining the integrity of the sensor with a good base line stability and easy sensor replacement. The sensor characteristics make it suitable for consideration as the elemental part of a sensor matrix in a multichannel platform for point of care applications. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-09-08 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://riunet.upv.es/handle/10251/148911 |
| url |
https://riunet.upv.es/handle/10251/148911 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 H2020 687785 Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reconocimiento (by) http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Reconocimiento (by) http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI AG |
| publisher.none.fl_str_mv |
MDPI AG |
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reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname:Universitat Politècnica de València (UPV) |
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Universitat Politècnica de València (UPV) |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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