Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women

This study was performed on scalp hair samples from postmenopausal women (n26; 12 normotensives and 14 hypertensives) to determine the relationship between blood pressure and metal and metalloids in hair samples. Hair concentrations of Al, Ba, Cd, Co, Cr, Mn, Mo, Ni, Pb, Sb, Se, Sr and V were measur...

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Autores: González-Muñoz, M. José, Sánchez-Muniz, F. J., Ródenas, S., Sevillano, M. I., Larrea, María Teresa, Bastida, Sara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/222253
Acceso en línea:http://hdl.handle.net/10261/222253
Access Level:acceso abierto
Palabra clave:Blood pressure
Hair minerals
Metals and metalloids
Postmenopausal women
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spelling Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal womenGonzález-Muñoz, M. JoséSánchez-Muniz, F. J.Ródenas, S.Sevillano, M. I.Larrea, María TeresaBastida, SaraBlood pressureHair mineralsMetals and metalloidsPostmenopausal womenThis study was performed on scalp hair samples from postmenopausal women (n26; 12 normotensives and 14 hypertensives) to determine the relationship between blood pressure and metal and metalloids in hair samples. Hair concentrations of Al, Ba, Cd, Co, Cr, Mn, Mo, Ni, Pb, Sb, Se, Sr and V were measured using inductively coupled plasma mass spectrometry, whereas Ca, Cu, Fe, K, Mg, Na and Zn concentrations were measured by inductively coupled plasma optical emission spectrometry. Methods were optimized and then validated using certified reference material GBW 09101 human hair. Although Cd, Co and Mo levels in hypertensive volunteers were significantly higher than in normotensive individuals (P<0.05), the concentrations of Fe, Mn, Na (all P<0.05) and K (P<0.001) were significantly lower. Concentrations of K (P<0.001; P<0.001) were negatively correlated with systolic and diastolic blood pressure. The concentration of Co (P<0.004; P<0.001) displayed a positive correlation with both types of pressure, whereas Cu (P<0.013) and Ni (P<0.001) concentrations correlated significantly with diastolic blood pressure and Mn negatively correlated with systolic blood pressure (P<0.031). Overweight and hypertension concurred in 27% of volunteers. This concurrence did not modify differences in hair mineral levels attributed to hypertension. The present results indicate that scalp hair concentrations of certain metals and metalloids can be used as biomarkers for hypertension in postmenopausal women.Springer NatureConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020102020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/222253reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1038/hr.2009.221Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2222532026-05-22T06:33:51Z
dc.title.none.fl_str_mv Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
title Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
spellingShingle Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
González-Muñoz, M. José
Blood pressure
Hair minerals
Metals and metalloids
Postmenopausal women
title_short Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
title_full Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
title_fullStr Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
title_full_unstemmed Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
title_sort Differences in metal and metalloid content in the hair of normo-and hypertensive postmenopausal women
dc.creator.none.fl_str_mv González-Muñoz, M. José
Sánchez-Muniz, F. J.
Ródenas, S.
Sevillano, M. I.
Larrea, María Teresa
Bastida, Sara
author González-Muñoz, M. José
author_facet González-Muñoz, M. José
Sánchez-Muniz, F. J.
Ródenas, S.
Sevillano, M. I.
Larrea, María Teresa
Bastida, Sara
author_role author
author2 Sánchez-Muniz, F. J.
Ródenas, S.
Sevillano, M. I.
Larrea, María Teresa
Bastida, Sara
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Blood pressure
Hair minerals
Metals and metalloids
Postmenopausal women
topic Blood pressure
Hair minerals
Metals and metalloids
Postmenopausal women
description This study was performed on scalp hair samples from postmenopausal women (n26; 12 normotensives and 14 hypertensives) to determine the relationship between blood pressure and metal and metalloids in hair samples. Hair concentrations of Al, Ba, Cd, Co, Cr, Mn, Mo, Ni, Pb, Sb, Se, Sr and V were measured using inductively coupled plasma mass spectrometry, whereas Ca, Cu, Fe, K, Mg, Na and Zn concentrations were measured by inductively coupled plasma optical emission spectrometry. Methods were optimized and then validated using certified reference material GBW 09101 human hair. Although Cd, Co and Mo levels in hypertensive volunteers were significantly higher than in normotensive individuals (P<0.05), the concentrations of Fe, Mn, Na (all P<0.05) and K (P<0.001) were significantly lower. Concentrations of K (P<0.001; P<0.001) were negatively correlated with systolic and diastolic blood pressure. The concentration of Co (P<0.004; P<0.001) displayed a positive correlation with both types of pressure, whereas Cu (P<0.013) and Ni (P<0.001) concentrations correlated significantly with diastolic blood pressure and Mn negatively correlated with systolic blood pressure (P<0.031). Overweight and hypertension concurred in 27% of volunteers. This concurrence did not modify differences in hair mineral levels attributed to hypertension. The present results indicate that scalp hair concentrations of certain metals and metalloids can be used as biomarkers for hypertension in postmenopausal women.
publishDate 2010
dc.date.none.fl_str_mv 2010
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/222253
url http://hdl.handle.net/10261/222253
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1038/hr.2009.221
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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