Involvement of dopamine in the regulation of dysfunctions related to depression in rodent models: motivational versus emotional symptoms
Depression is characterized by motivational symptoms such as anergia, fatigue and psychomotor slowing. These are highly resistant to treatment and often remain as residual symptoms after antidepressant drug therapy. It has been suggested that these effort-based symptoms are related to dysfunctions i...
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| Tipo de documento: | tese |
| Estado: | Versão publicada |
| Data de publicação: | 2020 |
| País: | España |
| Recursos: | CBUC, CESCA |
| Repositório: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/668932 |
| Acesso em linha: | http://hdl.handle.net/10803/668932 http://dx.doi.org/10.6035/14109.2020.368729 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Motivation Behavioral activation Dopamine Serotonin Depression Mice Salut i Serveis Socials 159.9 |
| Resumo: | Depression is characterized by motivational symptoms such as anergia, fatigue and psychomotor slowing. These are highly resistant to treatment and often remain as residual symptoms after antidepressant drug therapy. It has been suggested that these effort-based symptoms are related to dysfunctions in mesolimbic dopamine (DA). Thus, in the present dissertation has been characterized the impact of DA depletion and the ability of different antidepressants in reverse this DA depletion in several animal models that evaluate behavioral activation to escape an aversive situation or to approach and vigorously interact with a highly preferred reinforcer that competes with reinforcers by more passive behaviors. The effect of DA depletion and antidepressants also was studied in rodent models of anxiety-related behavior, another symptom common in some depressed people. |
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