Mimicking the extracellular matrix by incorporating functionalized graphene into hybrid hydrogels
The efficient functionalization of graphene with sulfonic groups using a sustainable approach facilitates the interaction of biomolecules with its surface. The inclusion of these graphene sheets inside a photopolymerized acrylamide-based hydrogel provides a 3D scaffold with viscoelastic behaviour cl...
| Autores: | , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Universidad de Castilla-La Mancha |
| Repositorio: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/32403 |
| Acesso em linha: | https://doi.org/10.1039/D3NR02689B https://hdl.handle.net/10578/32403 |
| Access Level: | acceso abierto |
| Palavra-chave: | Acrilamida Acrylamide Extracellular Matrix Graphite Hidrogeles Humans Hydrogels Matriz extracelular Neuroblastoma* |
| Resumo: | The efficient functionalization of graphene with sulfonic groups using a sustainable approach facilitates the interaction of biomolecules with its surface. The inclusion of these graphene sheets inside a photopolymerized acrylamide-based hydrogel provides a 3D scaffold with viscoelastic behaviour closer to that found in natural tissues. Cell-culture experiments and differentiation assays with SH-SY5Y cells showed that these hybrid hydrogels are non-cytotoxic, thus making them potentially useful as scaffold materials mimicking the extracellular environment |
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