Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device

Background and aim: Recent randomized data comparing percutaneous mitral valve repair (PMVR) versus optimal medical treatment in patients with functional MR (FMR) seemed to highlight the importance of the learning curve not only for procedural outcomes but also for patient selection. The aim of the...

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Autores: Freixa, X, Estevez-Loureiro, R, Carrasco-Chinchilla, F, Millan, X, Amat-Santos, I, Regueiro, A, Nombela-Franco, L, Pascual, I, Cid, B, Lopez-Minguez, JR, Hernandez-Antolin, RA, Cruz-Gonzalez, I, Andraka, L, Goicolea, J, Ruiz-Quevedo, V, Diez, JL, Berenguer, A, Baz, JA, Pan, MU, Benito-Gonzalez, T, Briales, JHA, Li, CH, Sanchis, L, Serrador, A, Jimenez-Quevedo, P, Avanzas, P, Salido, L, Fernandez-Vazquez, F, Hernandez-Garcia, JM, Arzamendi, D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p5056
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5056
Access Level:acceso abierto
Palabra clave:transcatheter mitral valve repair
mitral regurgitation
MitraClip
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spelling Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation DeviceFreixa, XEstevez-Loureiro, RCarrasco-Chinchilla, FMillan, XAmat-Santos, IRegueiro, ANombela-Franco, LPascual, ICid, BLopez-Minguez, JRHernandez-Antolin, RACruz-Gonzalez, IAndraka, LGoicolea, JRuiz-Quevedo, VDiez, JLBerenguer, ABaz, JAPan, MUBenito-Gonzalez, TBriales, JHALi, CHSanchis, LSerrador, AJimenez-Quevedo, PAvanzas, PSalido, LFernandez-Vazquez, FHernandez-Garcia, JMArzamendi, Dtranscatheter mitral valve repairmitral regurgitationMitraClipBackground and aim: Recent randomized data comparing percutaneous mitral valve repair (PMVR) versus optimal medical treatment in patients with functional MR (FMR) seemed to highlight the importance of the learning curve not only for procedural outcomes but also for patient selection. The aim of the study was to compare a contemporary series of patients undergoing PMVR using a second-generation Mitraclip device (Mitraclip NT) with previous cohorts treated with a first-generation system. Methods: This multicenter study collected individual data from 18 centers between 2012 and 2017. The cohort was divided into three groups according to the use of the first-generation Mitraclip during the first (control-1) or second half (control-2) or the Mitraclip NT system. Results: A total of 545 consecutive patients were included in the study. Among all, 182 (33.3%), 183 (33.3%), and 180 (33.3%) patients underwent mitral repair in the control-1, control-2, and NT cohorts, respectively. Procedural success was achieved in 93.3% of patients without differences between groups. Major adverse events did not statistically differ among groups, but there was a higher rate of pericardial effusion in the control-1 group (4.3%, 0.6%, and 2.6%, respectively; p = 0.025). The composite endpoint of death, surgery, and admission for congestive heart failure (CHF) at 12 months was lower in the NT group (23.5% in control-1, 22.5% in control-2, and 8.3% in the NT group; p = 0.032). Conclusions: The present paper shows that contemporary clinical outcomes of patients undergoing PMVR with the Mitraclip system have improved over time.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5056Journal of Clinical MedicineISSN: 20770383reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p50562026-06-14T12:41:47Z
dc.title.none.fl_str_mv Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
title Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
spellingShingle Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
Freixa, X
transcatheter mitral valve repair
mitral regurgitation
MitraClip
title_short Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
title_full Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
title_fullStr Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
title_full_unstemmed Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
title_sort Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device
dc.creator.none.fl_str_mv Freixa, X
Estevez-Loureiro, R
Carrasco-Chinchilla, F
Millan, X
Amat-Santos, I
Regueiro, A
Nombela-Franco, L
Pascual, I
Cid, B
Lopez-Minguez, JR
Hernandez-Antolin, RA
Cruz-Gonzalez, I
Andraka, L
Goicolea, J
Ruiz-Quevedo, V
Diez, JL
Berenguer, A
Baz, JA
Pan, MU
Benito-Gonzalez, T
Briales, JHA
Li, CH
Sanchis, L
Serrador, A
Jimenez-Quevedo, P
Avanzas, P
Salido, L
Fernandez-Vazquez, F
Hernandez-Garcia, JM
Arzamendi, D
author Freixa, X
author_facet Freixa, X
Estevez-Loureiro, R
Carrasco-Chinchilla, F
Millan, X
Amat-Santos, I
Regueiro, A
Nombela-Franco, L
Pascual, I
Cid, B
Lopez-Minguez, JR
Hernandez-Antolin, RA
Cruz-Gonzalez, I
Andraka, L
Goicolea, J
Ruiz-Quevedo, V
Diez, JL
Berenguer, A
Baz, JA
Pan, MU
Benito-Gonzalez, T
Briales, JHA
Li, CH
Sanchis, L
Serrador, A
Jimenez-Quevedo, P
Avanzas, P
Salido, L
Fernandez-Vazquez, F
Hernandez-Garcia, JM
Arzamendi, D
author_role author
author2 Estevez-Loureiro, R
Carrasco-Chinchilla, F
Millan, X
Amat-Santos, I
Regueiro, A
Nombela-Franco, L
Pascual, I
Cid, B
Lopez-Minguez, JR
Hernandez-Antolin, RA
Cruz-Gonzalez, I
Andraka, L
Goicolea, J
Ruiz-Quevedo, V
Diez, JL
Berenguer, A
Baz, JA
Pan, MU
Benito-Gonzalez, T
Briales, JHA
Li, CH
Sanchis, L
Serrador, A
Jimenez-Quevedo, P
Avanzas, P
Salido, L
Fernandez-Vazquez, F
Hernandez-Garcia, JM
Arzamendi, D
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv transcatheter mitral valve repair
mitral regurgitation
MitraClip
topic transcatheter mitral valve repair
mitral regurgitation
MitraClip
description Background and aim: Recent randomized data comparing percutaneous mitral valve repair (PMVR) versus optimal medical treatment in patients with functional MR (FMR) seemed to highlight the importance of the learning curve not only for procedural outcomes but also for patient selection. The aim of the study was to compare a contemporary series of patients undergoing PMVR using a second-generation Mitraclip device (Mitraclip NT) with previous cohorts treated with a first-generation system. Methods: This multicenter study collected individual data from 18 centers between 2012 and 2017. The cohort was divided into three groups according to the use of the first-generation Mitraclip during the first (control-1) or second half (control-2) or the Mitraclip NT system. Results: A total of 545 consecutive patients were included in the study. Among all, 182 (33.3%), 183 (33.3%), and 180 (33.3%) patients underwent mitral repair in the control-1, control-2, and NT cohorts, respectively. Procedural success was achieved in 93.3% of patients without differences between groups. Major adverse events did not statistically differ among groups, but there was a higher rate of pericardial effusion in the control-1 group (4.3%, 0.6%, and 2.6%, respectively; p = 0.025). The composite endpoint of death, surgery, and admission for congestive heart failure (CHF) at 12 months was lower in the NT group (23.5% in control-1, 22.5% in control-2, and 8.3% in the NT group; p = 0.032). Conclusions: The present paper shows that contemporary clinical outcomes of patients undergoing PMVR with the Mitraclip system have improved over time.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5056
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5056
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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