Estimating the Contribution of Renal Function to Endothelial Dysfunction and Subclinical Inflammation with a Two-Cohort Study

Living kidney transplantation offers the best results for end-stage renal disease patients, but concerns about cardiovascular risk after nephrectomy for kidney donors have been raised. We aimed to estimate the contribution of renal function to endothelial dysfunction (ED) and subclinical inflammatio...

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Detalhes bibliográficos
Autores: Torres, Irina B.|||0000-0003-3304-0810, Burballa, Carla|||0000-0002-0091-1459, Hernández, Domingo, Porrini, Esteban, Cortina, Vicente, Perelló, Manel|||0000-0003-1859-5279, Redondo-Pachón, Dolores|||0000-0002-0458-0052, Cabello, Mercedes, Pérez-Sáez, María José|||0000-0002-8601-2699, Crespo, Marta|||0000-0001-6992-6379, Seron, Daniel|||0000-0003-2054-653X, Moreso, Francesc|||0000-0002-7267-3963, González-Posada, José M., Perurena, Janire, González-Rine, Ana, Bestard, Oriol|||0000-0001-9468-7920
Tipo de documento: artigo
Data de publicação:2025
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:dnet:uabarcelona_::aef858f122b73f0306e28d368c4c3fba
Acesso em linha:https://ddd.uab.cat/record/328095
https://dx.doi.org/urn:doi:10.3390/ijms26199535
Access Level:Acceso aberto
Palavra-chave:Kidney transplantation
Living donor
Renal function
Iohexol clearance
Endothelial dysfunction
Inflammation
Descrição
Resumo:Living kidney transplantation offers the best results for end-stage renal disease patients, but concerns about cardiovascular risk after nephrectomy for kidney donors have been raised. We aimed to estimate the contribution of renal function to endothelial dysfunction (ED) and subclinical inflammation in a non-interventional, prospective, multicenter, longitudinal study with two cohorts: living kidney donors and their transplant recipients (registered clinical trial ). The measured glomerular filtration rate (mGFR) by iohexol clearance, estimated GFR according to the CKD-EPI and MDRD-4 formulas, and levels of endothelial dysfunction (sVCAM-1, sICAM-1, E-selectin, von Willebrand Factor, pentraxin, and urinary albumin-to-creatinine ratio) and subclinical inflammation biomarkers (sIL-6, sTNF-R1, sTNF-R2, sTWEAK, and high-sensitivity C-reactive protein) were determined at baseline and 1-year follow-up. Fifty pairs of donors and recipients were recruited between 2015 and 2018. Among the endothelial dysfunction biomarkers, sVCAM-1 increased in donors and decreased in recipients (p.

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