Accelerated Ru-Cu Trinuclear Cooperative C-H Bond Functionalization of Carbazoles
The mechanism of a trinuclear cooperative dehydrogenative C-N bond-forming reaction is investigated in this work, which avoids the use of chelate-assisting directing groups. Two new highly efficient Ru/Cu co-catalyzed systems were identified, allowing orders of magnitude greater TOFs than the previo...
| Autores: | , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:227933 |
| Acesso em linha: | https://ddd.uab.cat/record/227933 https://dx.doi.org/urn:doi:10.1002/chem.201802886 |
| Access Level: | acceso abierto |
| Palavra-chave: | C-H bond activation Cooperative reductive elimination Cross dehydrogenative coupling Dehydrogenative amination Trinuclear catalysis |
| Resumo: | The mechanism of a trinuclear cooperative dehydrogenative C-N bond-forming reaction is investigated in this work, which avoids the use of chelate-assisting directing groups. Two new highly efficient Ru/Cu co-catalyzed systems were identified, allowing orders of magnitude greater TOFs than the previous state of the art. In-depth kinetic studies were performed in combination with advanced DFT calculations, which reveal a decisive rate-determining trinuclear Ru-Cu cooperative reductive elimination step (CRE). |
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