Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis

4 pages, 2 figures.-- PMID: 15178065 [PubMed].-- Printed version published in issue Aug-Dec 2004.-- Issue title: "Twelfth International Symposium on Pollutant Responses in Marine Organisms" (Tampa Bay, FL, United States, May 9-13, 2003).

Detalhes bibliográficos
Autores: Janer, Gemma, Lavado Parra, Ramón, Thibaut, Rémi, Porte Visa, Cinta
Formato: artículo
Fecha de publicación:2004
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/17645
Acesso em linha:http://hdl.handle.net/10261/17645
Access Level:acceso abierto
Palavra-chave:Estradiol
Mytilus galloprovincialis
P450-aromatase
Esterification
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spelling Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialisJaner, GemmaLavado Parra, RamónThibaut, RémiPorte Visa, CintaEstradiolMytilus galloprovincialisP450-aromataseEsterification4 pages, 2 figures.-- PMID: 15178065 [PubMed].-- Printed version published in issue Aug-Dec 2004.-- Issue title: "Twelfth International Symposium on Pollutant Responses in Marine Organisms" (Tampa Bay, FL, United States, May 9-13, 2003).Mussels Mytilus galloprovincialis were exposed to different concentrations of estradiol (20, 200, and 2000 ng/l) in a semi-static regime (1-day dosing intervals) for up to 7 days in an attempt to see how mussels dealt with exogenous estrogenic compounds. Sex hormone levels were determined in whole tissue. Free-estradiol was only significantly elevated at the highest exposure dose (up to 10-fold). Most of the estradiol was in the tissues as fatty acid esters (>78%), which sharply increased in a dose-dependent manner (from 4 ng/g in controls to 258 ng/g at the high exposure group). In contrast, neither free nor esterified testosterone levels showed significant differences between control and exposure groups. The results suggest the existence of mechanisms that allow mussels to maintain their hormonal status, and the important role that fatty acid esterification may play within those mechanisms. Synthesis and conjugation rates of estradiol were further investigated by measuring the activity of P450 aromatase, and palmitoyl-CoA:estradiol acyltransferase, in digestive gland microsomal fractions. Overall, the study contributes to the better knowledge of molluscan endocrinology, and defines new mechanisms of regulation of free steroid-levels in mussels.Predoctoral fellowship from the Spanish Government and partial support from EU Project BEEP (ENVK3-CT-2000-00025).Peer reviewedElsevier200920092004info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_650122195 bytesapplication/pdfhttp://hdl.handle.net/10261/17645reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.marenvres.2004.03.028info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/176452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
title Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
spellingShingle Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
Janer, Gemma
Estradiol
Mytilus galloprovincialis
P450-aromatase
Esterification
title_short Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
title_full Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
title_fullStr Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
title_full_unstemmed Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
title_sort Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis
dc.creator.none.fl_str_mv Janer, Gemma
Lavado Parra, Ramón
Thibaut, Rémi
Porte Visa, Cinta
author Janer, Gemma
author_facet Janer, Gemma
Lavado Parra, Ramón
Thibaut, Rémi
Porte Visa, Cinta
author_role author
author2 Lavado Parra, Ramón
Thibaut, Rémi
Porte Visa, Cinta
author2_role author
author
author
dc.subject.none.fl_str_mv Estradiol
Mytilus galloprovincialis
P450-aromatase
Esterification
topic Estradiol
Mytilus galloprovincialis
P450-aromatase
Esterification
description 4 pages, 2 figures.-- PMID: 15178065 [PubMed].-- Printed version published in issue Aug-Dec 2004.-- Issue title: "Twelfth International Symposium on Pollutant Responses in Marine Organisms" (Tampa Bay, FL, United States, May 9-13, 2003).
publishDate 2004
dc.date.none.fl_str_mv 2004
2009
2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/17645
url http://hdl.handle.net/10261/17645
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.marenvres.2004.03.028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22195 bytes
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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