Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.

In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meio...

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Authors: Daga, Rafael, Salas-Pino, Silvia, Flor-Parra, Ignacio, Iglesias Romero, Ana Belén, Lucena Rafael, Jiménez, Juan
Format: article
Publication Date:2018
Country:España
Institution:Universidad Pablo de Olavide (UPO)
Repository:RIO. Repositorio Institucional Olavide
Language:English
OAI Identifier:oai:rio.upo.es:10433/25242
Online Access:https://hdl.handle.net/10433/25242
Access Level:Open access
Keyword:Schizosaccharomyces pombe
Fission yeast
Nucleocytoplasmic transport
Imp1
vNEBD
Nuclear envelope
Meiosis
Spindle disassembly
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spelling Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.Daga, RafaelSalas-Pino, SilviaFlor-Parra, IgnacioIglesias Romero, Ana BelénLucena RafaelJiménez, JuanSchizosaccharomyces pombeFission yeastNucleocytoplasmic transportImp1vNEBDNuclear envelopeMeiosisSpindle disassemblyIn metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also maintained, but nuclear and cytoplasmic molecules are mixed similarly to open mitosis, a phenomenon of unknown biological significance called "virtual" NEBD (vNEBD). Here, we show that importin-α-dependent nucleocytoplasmic transport regulates spindle disassembly late in anaphase B at MI, as previously reported for mitosis. At MII, however, spindle dissolution is triggered by vNEBD early in anaphase B, a mechanism that short-circuits the nucleocytoplasmic transport system. We demonstrate that the sequential action of these two spindle disassembly systems regulates the spatiotemporal order and ploidy of the meiotic products.Cell Press20252025-12-1720182018-04-2420182018-04-24journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10433/25242reponame:RIO. Repositorio Institucional Olavideinstname:Universidad Pablo de Olavide (UPO)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:rio.upo.es:10433/252422026-06-13T12:46:27Z
dc.title.none.fl_str_mv Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
title Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
spellingShingle Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
Daga, Rafael
Schizosaccharomyces pombe
Fission yeast
Nucleocytoplasmic transport
Imp1
vNEBD
Nuclear envelope
Meiosis
Spindle disassembly
title_short Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
title_full Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
title_fullStr Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
title_full_unstemmed Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
title_sort Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
dc.creator.none.fl_str_mv Daga, Rafael
Salas-Pino, Silvia
Flor-Parra, Ignacio
Iglesias Romero, Ana Belén
Lucena Rafael
Jiménez, Juan
author Daga, Rafael
author_facet Daga, Rafael
Salas-Pino, Silvia
Flor-Parra, Ignacio
Iglesias Romero, Ana Belén
Lucena Rafael
Jiménez, Juan
author_role author
author2 Salas-Pino, Silvia
Flor-Parra, Ignacio
Iglesias Romero, Ana Belén
Lucena Rafael
Jiménez, Juan
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Schizosaccharomyces pombe
Fission yeast
Nucleocytoplasmic transport
Imp1
vNEBD
Nuclear envelope
Meiosis
Spindle disassembly
topic Schizosaccharomyces pombe
Fission yeast
Nucleocytoplasmic transport
Imp1
vNEBD
Nuclear envelope
Meiosis
Spindle disassembly
description In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also maintained, but nuclear and cytoplasmic molecules are mixed similarly to open mitosis, a phenomenon of unknown biological significance called "virtual" NEBD (vNEBD). Here, we show that importin-α-dependent nucleocytoplasmic transport regulates spindle disassembly late in anaphase B at MI, as previously reported for mitosis. At MII, however, spindle dissolution is triggered by vNEBD early in anaphase B, a mechanism that short-circuits the nucleocytoplasmic transport system. We demonstrate that the sequential action of these two spindle disassembly systems regulates the spatiotemporal order and ploidy of the meiotic products.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-04-24
2018
2018-04-24
2025
2025-12-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10433/25242
url https://hdl.handle.net/10433/25242
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:RIO. Repositorio Institucional Olavide
instname:Universidad Pablo de Olavide (UPO)
instname_str Universidad Pablo de Olavide (UPO)
reponame_str RIO. Repositorio Institucional Olavide
collection RIO. Repositorio Institucional Olavide
repository.name.fl_str_mv
repository.mail.fl_str_mv
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