An emerging role for synaptic Zn2+ in substance use disorders
Synaptic zinc (Zn<sup>2+</sup>) modulates dopamine and glutamate neurotransmission by binding to the dopamine transporter and glutamate receptors. Among other neurotransmitters, dopamine and glutamate critically regulate physiological processes and behaviors relevant to substance use dis...
| Autores: | , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:dnet:recercat____::f3298137c30d5531fa59cfc815b3e372 |
| Acesso em linha: | https://hdl.handle.net/2445/229332 |
| Access Level: | acceso abierto |
| Palavra-chave: | Opiacis Receptors de neurotransmissors Dopamina Zinc en l'organisme Opioids Neurotransmitter receptors Dopamine Zinc in the body |
| Resumo: | Synaptic zinc (Zn<sup>2+</sup>) modulates dopamine and glutamate neurotransmission by binding to the dopamine transporter and glutamate receptors. Among other neurotransmitters, dopamine and glutamate critically regulate physiological processes and behaviors relevant to substance use disorders (SUDs) and addiction. In addition, Zn<sup>2+</sup> interacts with inhibitory neurotransmitter systems, including GABA and glycine receptors, further influencing the excitatory-inhibitory balance within circuits relevant to addiction. Nevertheless, the specific involvement of synaptic Zn<sup>2+</sup> in such processes is unknown. We propose that synaptic Zn<sup>2+</sup> serves as an environmentally derived factor that can influence the vulnerability to and development of SUDs and addiction via its interaction with proteins that regulate dopamine and glutamate neurotransmission in addiction-relevant brain circuits. |
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