Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer

Objectives: The prevalence, clinical characteristics and prognosis of pleural effusions (PEs) associated with ovarian cancer (OC) have seldom been addressed systematically, as in the current investigation. Methods: All records of consecutive women with a newly diagnosed OC in our institution over a...

Descripción completa

Detalles Bibliográficos
Autores: Porcel Pérez, José Manuel, Murata, Paola, Porcel, Laura, Bielsa Martín, Silvia, Pardina Solano, Marina Asunción, Salud Salvia, Maria Antonieta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/72070
Acceso en línea:https://doi.org/10.1515/pp-2020-0152
http://hdl.handle.net/10459.1/72070
Access Level:acceso abierto
Palabra clave:Indwelling pleural catheter
Ovarian cancer
Pleural effusion
Pleurodesis
Survival
id ES_22dfd14e35ab0ce2e02d220106ecfdd9
oai_identifier_str oai:repositori.udl.cat:10459.1/72070
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancerPorcel Pérez, José ManuelMurata, PaolaPorcel, LauraBielsa Martín, SilviaPardina Solano, Marina AsunciónSalud Salvia, Maria AntonietaIndwelling pleural catheterOvarian cancerPleural effusionPleurodesisSurvivalObjectives: The prevalence, clinical characteristics and prognosis of pleural effusions (PEs) associated with ovarian cancer (OC) have seldom been addressed systematically, as in the current investigation. Methods: All records of consecutive women with a newly diagnosed OC in our institution over a 13-year period were retrospectively reviewed. Features of PEs on CT scans, pleural fluid analyses, need for definitive therapy of PEs, and the influence of PEs on the overall survival (OS) and progression-free survival (PFS) were evaluated. Results: PEs were observed in 81 (43%) of 189 women with OC, either at presentation of cancer (55 patients) or during the course of the disease (26 patients). The causes of PEs were malignancy (55.5%), unknown (37%), or surgery-related (7.4%). The sensitivity of the cytologic diagnosis of malignant PEs was 79.1%. Sixty percent of malignant PEs required pleurodesis or indwelling pleural catheters for symptomatic relief. The presence of ascites strongly predicted PE development (odds ratio 43.2). Women with PEs fared much worse compared with those without PEs, in terms of OS (26.7 vs. 90.4 months), PFS (9.8 vs. 55.3 months) and tumor recurrences (86.4 vs. 43%). In multivariate analyses, PE remained as a relevant independent variable associated with poor outcome (hazard ratio 9.73 for OS, and 3.87 for PFS). Notably, PEs small enough to preclude tapping, and thus of unknown origin, had a similar bad prognosis as malignant PEs. Conclusions: OC patients with PEs experience decreased survival, including those with trace effusions not amenable to tappingDe Gruyter2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1515/pp-2020-0152http://hdl.handle.net/10459.1/72070reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.1515/pp-2020-0152Pleura and Peritoneum, 2021, vol. 6, núm. 2, p. 75-81cc-by (c) Porcel et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/720702026-06-24T12:42:17Z
dc.title.none.fl_str_mv Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
title Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
spellingShingle Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
Porcel Pérez, José Manuel
Indwelling pleural catheter
Ovarian cancer
Pleural effusion
Pleurodesis
Survival
title_short Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
title_full Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
title_fullStr Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
title_full_unstemmed Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
title_sort Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer
dc.creator.none.fl_str_mv Porcel Pérez, José Manuel
Murata, Paola
Porcel, Laura
Bielsa Martín, Silvia
Pardina Solano, Marina Asunción
Salud Salvia, Maria Antonieta
author Porcel Pérez, José Manuel
author_facet Porcel Pérez, José Manuel
Murata, Paola
Porcel, Laura
Bielsa Martín, Silvia
Pardina Solano, Marina Asunción
Salud Salvia, Maria Antonieta
author_role author
author2 Murata, Paola
Porcel, Laura
Bielsa Martín, Silvia
Pardina Solano, Marina Asunción
Salud Salvia, Maria Antonieta
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Indwelling pleural catheter
Ovarian cancer
Pleural effusion
Pleurodesis
Survival
topic Indwelling pleural catheter
Ovarian cancer
Pleural effusion
Pleurodesis
Survival
description Objectives: The prevalence, clinical characteristics and prognosis of pleural effusions (PEs) associated with ovarian cancer (OC) have seldom been addressed systematically, as in the current investigation. Methods: All records of consecutive women with a newly diagnosed OC in our institution over a 13-year period were retrospectively reviewed. Features of PEs on CT scans, pleural fluid analyses, need for definitive therapy of PEs, and the influence of PEs on the overall survival (OS) and progression-free survival (PFS) were evaluated. Results: PEs were observed in 81 (43%) of 189 women with OC, either at presentation of cancer (55 patients) or during the course of the disease (26 patients). The causes of PEs were malignancy (55.5%), unknown (37%), or surgery-related (7.4%). The sensitivity of the cytologic diagnosis of malignant PEs was 79.1%. Sixty percent of malignant PEs required pleurodesis or indwelling pleural catheters for symptomatic relief. The presence of ascites strongly predicted PE development (odds ratio 43.2). Women with PEs fared much worse compared with those without PEs, in terms of OS (26.7 vs. 90.4 months), PFS (9.8 vs. 55.3 months) and tumor recurrences (86.4 vs. 43%). In multivariate analyses, PE remained as a relevant independent variable associated with poor outcome (hazard ratio 9.73 for OS, and 3.87 for PFS). Notably, PEs small enough to preclude tapping, and thus of unknown origin, had a similar bad prognosis as malignant PEs. Conclusions: OC patients with PEs experience decreased survival, including those with trace effusions not amenable to tapping
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1515/pp-2020-0152
http://hdl.handle.net/10459.1/72070
url https://doi.org/10.1515/pp-2020-0152
http://hdl.handle.net/10459.1/72070
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1515/pp-2020-0152
Pleura and Peritoneum, 2021, vol. 6, núm. 2, p. 75-81
dc.rights.none.fl_str_mv cc-by (c) Porcel et al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Porcel et al., 2021
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404607015288832
score 15.812455

Similares en LA Referencia