Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).

Immune thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare disease that seldom occurs in the elderly. Few reports have studied the clinical course of iTTP in older patients. In this study, we have analysed the clinical characteristics at presentation and response to therapy in a series of 44...

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Autores: Gómez-Seguí I, Francés Aracil E, Mingot-Castellano ME, Vara Pampliega M, Goterris Viciedo R, García Candel F, Pascual Izquierdo C, Del Río Garma J, Guerra Domínguez L, Vicuña Andrés I, Garcia-Arroba Peinado J, Zalba Marcos S, Vidan Estévez JM, González Arias E, Campuzano Saavedra V, García Gala JM, Ortega Sanchez S, Martínez Nieto J, Pardo Gambarte L, Solé Rodríguez M, Fernández-Docampo M, Avila Idrovo LF, Hernández L, Cid J, de la Rubia Comos J
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p15674
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/15674
Access Level:acceso abierto
Palavra-chave:aged
caplacizumab
rituximab
thrombotic thrombocytopenic purpura
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).Gómez-Seguí IFrancés Aracil EMingot-Castellano MEVara Pampliega MGoterris Viciedo RGarcía Candel FPascual Izquierdo CDel Río Garma JGuerra Domínguez LVicuña Andrés IGarcia-Arroba Peinado JZalba Marcos SVidan Estévez JMGonzález Arias ECampuzano Saavedra VGarcía Gala JMOrtega Sanchez SMartínez Nieto JPardo Gambarte LSolé Rodríguez MFernández-Docampo MAvila Idrovo LFHernández LCid Jde la Rubia Comos Jagedcaplacizumabrituximabthrombotic thrombocytopenic purpuraImmune thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare disease that seldom occurs in the elderly. Few reports have studied the clinical course of iTTP in older patients. In this study, we have analysed the clinical characteristics at presentation and response to therapy in a series of 44 patients with iTTP =60 years at diagnosis from the Spanish TTP Registry and compared them with 209 patients with <60 years at diagnosis from the same Registry. Similar symptoms and laboratory results were described in both groups, except for a higher incidence of renal dysfunction among older patients (23% vs. 43.1%; p = 0.008). Front-line treatment in patients =60 years was like that administered in younger patients. Also, no evidence of a difference in clinical response and overall survival was seen in both groups. Of note, 14 and 25 patients =60 years received treatment with caplacizumab and rituximab, respectively, showing a favourable safety and efficacy profile, like that observed in patients <60 years.WILEY2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/15674BRITISH JOURNAL OF HAEMATOLOGYISSN: 00071048ISSNe: 13652141reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p156742026-06-11T12:45:17Z
dc.title.none.fl_str_mv Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
title Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
spellingShingle Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
Gómez-Seguí I
aged
caplacizumab
rituximab
thrombotic thrombocytopenic purpura
title_short Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
title_full Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
title_fullStr Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
title_full_unstemmed Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
title_sort Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT).
dc.creator.none.fl_str_mv Gómez-Seguí I
Francés Aracil E
Mingot-Castellano ME
Vara Pampliega M
Goterris Viciedo R
García Candel F
Pascual Izquierdo C
Del Río Garma J
Guerra Domínguez L
Vicuña Andrés I
Garcia-Arroba Peinado J
Zalba Marcos S
Vidan Estévez JM
González Arias E
Campuzano Saavedra V
García Gala JM
Ortega Sanchez S
Martínez Nieto J
Pardo Gambarte L
Solé Rodríguez M
Fernández-Docampo M
Avila Idrovo LF
Hernández L
Cid J
de la Rubia Comos J
author Gómez-Seguí I
author_facet Gómez-Seguí I
Francés Aracil E
Mingot-Castellano ME
Vara Pampliega M
Goterris Viciedo R
García Candel F
Pascual Izquierdo C
Del Río Garma J
Guerra Domínguez L
Vicuña Andrés I
Garcia-Arroba Peinado J
Zalba Marcos S
Vidan Estévez JM
González Arias E
Campuzano Saavedra V
García Gala JM
Ortega Sanchez S
Martínez Nieto J
Pardo Gambarte L
Solé Rodríguez M
Fernández-Docampo M
Avila Idrovo LF
Hernández L
Cid J
de la Rubia Comos J
author_role author
author2 Francés Aracil E
Mingot-Castellano ME
Vara Pampliega M
Goterris Viciedo R
García Candel F
Pascual Izquierdo C
Del Río Garma J
Guerra Domínguez L
Vicuña Andrés I
Garcia-Arroba Peinado J
Zalba Marcos S
Vidan Estévez JM
González Arias E
Campuzano Saavedra V
García Gala JM
Ortega Sanchez S
Martínez Nieto J
Pardo Gambarte L
Solé Rodríguez M
Fernández-Docampo M
Avila Idrovo LF
Hernández L
Cid J
de la Rubia Comos J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv aged
caplacizumab
rituximab
thrombotic thrombocytopenic purpura
topic aged
caplacizumab
rituximab
thrombotic thrombocytopenic purpura
description Immune thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare disease that seldom occurs in the elderly. Few reports have studied the clinical course of iTTP in older patients. In this study, we have analysed the clinical characteristics at presentation and response to therapy in a series of 44 patients with iTTP =60 years at diagnosis from the Spanish TTP Registry and compared them with 209 patients with <60 years at diagnosis from the same Registry. Similar symptoms and laboratory results were described in both groups, except for a higher incidence of renal dysfunction among older patients (23% vs. 43.1%; p = 0.008). Front-line treatment in patients =60 years was like that administered in younger patients. Also, no evidence of a difference in clinical response and overall survival was seen in both groups. Of note, 14 and 25 patients =60 years received treatment with caplacizumab and rituximab, respectively, showing a favourable safety and efficacy profile, like that observed in patients <60 years.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/15674
url https://fisabio.portalinvestigacion.com/publicaciones/15674
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv BRITISH JOURNAL OF HAEMATOLOGY
ISSN: 00071048
ISSNe: 13652141
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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