Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach
Bioaccumulation of pharmaceuticals in fish exposed to contaminated water can be shaped by their capability to metabolize these xenobiotics, affecting their toxicity and animal welfare. In this study the in vivo metabolization of the antidepressant venlafaxine by the juvenile marine fish meagre (Argy...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10256/18369 |
| Acceso en línea: | http://hdl.handle.net/10256/18369 |
| Access Level: | acceso abierto |
| Palabra clave: | Toxicologia ambiental Environmental toxicology Contaminants emergents en l'aigua Emerging contaminants in water Peixos -- Efecte de la contaminació de l'aigua Fishes -- Effect of water pollution on Peixos -- Efecte dels productes químics Fishes -- Effect of chemicals on |
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Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approachSantos, Lúcia HelenaMaulvault, Ana LuísaJaén Gil, AdriánMarques, AntónioBarceló i Cullerés, DamiàRodríguez Mozaz, SaraToxicologia ambientalEnvironmental toxicologyContaminants emergents en l'aiguaEmerging contaminants in waterPeixos -- Efecte de la contaminació de l'aiguaFishes -- Effect of water pollution onPeixos -- Efecte dels productes químicsFishes -- Effect of chemicals onBioaccumulation of pharmaceuticals in fish exposed to contaminated water can be shaped by their capability to metabolize these xenobiotics, affecting their toxicity and animal welfare. In this study the in vivo metabolization of the antidepressant venlafaxine by the juvenile marine fish meagre (Argyrosomus regius) was evaluated using a combined target and suspect screening analytical approach. Thirteen venlafaxine metabolites were identified, namely N-desmethylvenlafaxine and N,N-didesmethylvenlafaxine, which were unequivocally identified using analytical standards, and 11 more tentatively identified by suspect screening analysis, including two Phase II metabolites formed by amino acid conjugation. All of them were detected in the liver, while in plasma and brain only 9 and 6 metabolites, respectively, were detected. Based on these findings, for the first time, a tentative metabolization pathway of venlafaxine by A. regius is proposed. Contrarily to what happen in humans, N-demethylation was identified as the main route of metabolization of venlafaxine by fish. Our findings highlight species-specificity in the metabolization of venlafaxine and allow a better understanding of venlafaxine's toxicokinetic in fish. These results emphasize the need to investigate the biotransformation of xenobiotics by non-target organisms to have an integrated overview of their environmental exposure and to improve future evaluations of environmental risk assessmentThis work was funded by the 7th EU-FP (ECsafeSEAFOOD project; GA n° 311820) and the European Regional Development Fund (FEDER) and by Spanish Ministry of Economy and Competitiveness (PGE-2010). This work was also funded by the Spanish State Research Agency of the Spanish Ministry of Science, Innovation and Universities and European Fund for Regional Development (project PLAS-MED; FEDER-MCIU-AEI/CTM2017-89701-C3-2-R). Authors thank Generalitat de Catalunya through Consolidated Research Group (ICRA-ENV 2017 SGR 1124 & 2017 SGR 1404). ICRA researchers thank funding from CERCA program. Lúcia H.M.L.M. Santos thanks the Juan de la Cierva program (IJCI-2017-32747) and Sara Rodríguez-Mozaz thanks the Ramon y Cajal program (RYC-2014-16707) from the Spanish State Research Agency of the Spanish Ministry of Science, Innovation and Universities (AEI-MCIU). A. Jaén-Gil thanks the predoctoral grant from the Agency for Management of University and Research Grants (AGAUR) (2019FI_B2_00202) co-financed by the European Social Fund. A. Marques (IF program) and A.L. Maulvault (Project FishBudget PTDC/BIA-BMA/28630/2017) thank the Portuguese Foundation for Science and TechnologyElsevierMinisterio de Ciencia e Innovación (Espanya)info2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/18369© Science of The Total Environment, 2020. vol. 737, art. núm. 140226Articles publicats (ICRA)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.scitotenv.2020.140226info:eu-repo/semantics/altIdentifier/issn/0048-9697info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTM2017-89701-C3-2-Rinfo:eu-repo/grantAgreement/EC/FP7/311820InChttps://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/183692026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach |
| title |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach |
| spellingShingle |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach Santos, Lúcia Helena Toxicologia ambiental Environmental toxicology Contaminants emergents en l'aigua Emerging contaminants in water Peixos -- Efecte de la contaminació de l'aigua Fishes -- Effect of water pollution on Peixos -- Efecte dels productes químics Fishes -- Effect of chemicals on |
| title_short |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach |
| title_full |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach |
| title_fullStr |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach |
| title_full_unstemmed |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach |
| title_sort |
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach |
| dc.creator.none.fl_str_mv |
Santos, Lúcia Helena Maulvault, Ana Luísa Jaén Gil, Adrián Marques, António Barceló i Cullerés, Damià Rodríguez Mozaz, Sara |
| author |
Santos, Lúcia Helena |
| author_facet |
Santos, Lúcia Helena Maulvault, Ana Luísa Jaén Gil, Adrián Marques, António Barceló i Cullerés, Damià Rodríguez Mozaz, Sara |
| author_role |
author |
| author2 |
Maulvault, Ana Luísa Jaén Gil, Adrián Marques, António Barceló i Cullerés, Damià Rodríguez Mozaz, Sara |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Ciencia e Innovación (Espanya) |
| dc.subject.none.fl_str_mv |
Toxicologia ambiental Environmental toxicology Contaminants emergents en l'aigua Emerging contaminants in water Peixos -- Efecte de la contaminació de l'aigua Fishes -- Effect of water pollution on Peixos -- Efecte dels productes químics Fishes -- Effect of chemicals on |
| topic |
Toxicologia ambiental Environmental toxicology Contaminants emergents en l'aigua Emerging contaminants in water Peixos -- Efecte de la contaminació de l'aigua Fishes -- Effect of water pollution on Peixos -- Efecte dels productes químics Fishes -- Effect of chemicals on |
| description |
Bioaccumulation of pharmaceuticals in fish exposed to contaminated water can be shaped by their capability to metabolize these xenobiotics, affecting their toxicity and animal welfare. In this study the in vivo metabolization of the antidepressant venlafaxine by the juvenile marine fish meagre (Argyrosomus regius) was evaluated using a combined target and suspect screening analytical approach. Thirteen venlafaxine metabolites were identified, namely N-desmethylvenlafaxine and N,N-didesmethylvenlafaxine, which were unequivocally identified using analytical standards, and 11 more tentatively identified by suspect screening analysis, including two Phase II metabolites formed by amino acid conjugation. All of them were detected in the liver, while in plasma and brain only 9 and 6 metabolites, respectively, were detected. Based on these findings, for the first time, a tentative metabolization pathway of venlafaxine by A. regius is proposed. Contrarily to what happen in humans, N-demethylation was identified as the main route of metabolization of venlafaxine by fish. Our findings highlight species-specificity in the metabolization of venlafaxine and allow a better understanding of venlafaxine's toxicokinetic in fish. These results emphasize the need to investigate the biotransformation of xenobiotics by non-target organisms to have an integrated overview of their environmental exposure and to improve future evaluations of environmental risk assessment |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 info |
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info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion peer-reviewed |
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article |
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acceptedVersion |
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http://hdl.handle.net/10256/18369 |
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http://hdl.handle.net/10256/18369 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.scitotenv.2020.140226 info:eu-repo/semantics/altIdentifier/issn/0048-9697 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTM2017-89701-C3-2-R info:eu-repo/grantAgreement/EC/FP7/311820 |
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InC https://rightsstatements.org/vocab/InC/1.0/ info:eu-repo/semantics/openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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© Science of The Total Environment, 2020. vol. 737, art. núm. 140226 Articles publicats (ICRA) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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