Outcomes of Frail Patients While Waiting for Kidney Transplantation

Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physica...

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Autores: Pérez-Sáez, María José|||0000-0002-8601-2699, Redondo-Pachón, Dolores|||0000-0002-0458-0052, Arias Cabrales, Carlos E|||0000-0002-1729-8152, Faura, Anna|||0000-0002-1440-3922, Bach Pascual, Anna|||0000-0003-0571-6131, Buxeda, Anna|||0000-0001-7305-3259, Burballa, Carla|||0000-0002-0091-1459, Junyent, Ernestina, Crespo, Marta|||0000-0001-6992-6379, Marco, Ester|||0000-0002-3412-0356, Rodríguez-Mañas, Leocadio|||0000-0002-6551-1333, Pascual, Julio|||0000-0002-4735-7838
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256043
Acceso en línea:https://ddd.uab.cat/record/256043
https://dx.doi.org/urn:doi:10.3390/jcm11030672
Access Level:acceso abierto
Palabra clave:Frailty
FRAIL
Kidney transplant waiting list
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spelling Outcomes of Frail Patients While Waiting for Kidney TransplantationDifferences between Physical Frailty Phenotype and FRAIL ScalePérez-Sáez, María José|||0000-0002-8601-2699Redondo-Pachón, Dolores|||0000-0002-0458-0052Arias Cabrales, Carlos E|||0000-0002-1729-8152Faura, Anna|||0000-0002-1440-3922Bach Pascual, Anna|||0000-0003-0571-6131Buxeda, Anna|||0000-0001-7305-3259Burballa, Carla|||0000-0002-0091-1459Junyent, ErnestinaCrespo, Marta|||0000-0001-6992-6379Marco, Ester|||0000-0002-3412-0356Rodríguez-Mañas, Leocadio|||0000-0002-6551-1333Pascual, Julio|||0000-0002-4735-7838FrailtyFRAILKidney transplant waiting listFrailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16.3 vs. 7.4%, p = 0.013). Robust patients had fewer hospital admissions during the 1st year after listing (20.8% if PFP = 0 vs. 43.4% if ≥1, and 27.1% if FRAIL = 0 vs. 48.9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0.45 [0.26-0.77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256043https://dx.doi.org/urn:doi:10.3390/jcm11030672reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00037open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2560432026-06-06T12:50:31Z
dc.title.none.fl_str_mv Outcomes of Frail Patients While Waiting for Kidney Transplantation
Differences between Physical Frailty Phenotype and FRAIL Scale
title Outcomes of Frail Patients While Waiting for Kidney Transplantation
spellingShingle Outcomes of Frail Patients While Waiting for Kidney Transplantation
Pérez-Sáez, María José|||0000-0002-8601-2699
Frailty
FRAIL
Kidney transplant waiting list
title_short Outcomes of Frail Patients While Waiting for Kidney Transplantation
title_full Outcomes of Frail Patients While Waiting for Kidney Transplantation
title_fullStr Outcomes of Frail Patients While Waiting for Kidney Transplantation
title_full_unstemmed Outcomes of Frail Patients While Waiting for Kidney Transplantation
title_sort Outcomes of Frail Patients While Waiting for Kidney Transplantation
dc.creator.none.fl_str_mv Pérez-Sáez, María José|||0000-0002-8601-2699
Redondo-Pachón, Dolores|||0000-0002-0458-0052
Arias Cabrales, Carlos E|||0000-0002-1729-8152
Faura, Anna|||0000-0002-1440-3922
Bach Pascual, Anna|||0000-0003-0571-6131
Buxeda, Anna|||0000-0001-7305-3259
Burballa, Carla|||0000-0002-0091-1459
Junyent, Ernestina
Crespo, Marta|||0000-0001-6992-6379
Marco, Ester|||0000-0002-3412-0356
Rodríguez-Mañas, Leocadio|||0000-0002-6551-1333
Pascual, Julio|||0000-0002-4735-7838
author Pérez-Sáez, María José|||0000-0002-8601-2699
author_facet Pérez-Sáez, María José|||0000-0002-8601-2699
Redondo-Pachón, Dolores|||0000-0002-0458-0052
Arias Cabrales, Carlos E|||0000-0002-1729-8152
Faura, Anna|||0000-0002-1440-3922
Bach Pascual, Anna|||0000-0003-0571-6131
Buxeda, Anna|||0000-0001-7305-3259
Burballa, Carla|||0000-0002-0091-1459
Junyent, Ernestina
Crespo, Marta|||0000-0001-6992-6379
Marco, Ester|||0000-0002-3412-0356
Rodríguez-Mañas, Leocadio|||0000-0002-6551-1333
Pascual, Julio|||0000-0002-4735-7838
author_role author
author2 Redondo-Pachón, Dolores|||0000-0002-0458-0052
Arias Cabrales, Carlos E|||0000-0002-1729-8152
Faura, Anna|||0000-0002-1440-3922
Bach Pascual, Anna|||0000-0003-0571-6131
Buxeda, Anna|||0000-0001-7305-3259
Burballa, Carla|||0000-0002-0091-1459
Junyent, Ernestina
Crespo, Marta|||0000-0001-6992-6379
Marco, Ester|||0000-0002-3412-0356
Rodríguez-Mañas, Leocadio|||0000-0002-6551-1333
Pascual, Julio|||0000-0002-4735-7838
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Frailty
FRAIL
Kidney transplant waiting list
topic Frailty
FRAIL
Kidney transplant waiting list
description Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16.3 vs. 7.4%, p = 0.013). Robust patients had fewer hospital admissions during the 1st year after listing (20.8% if PFP = 0 vs. 43.4% if ≥1, and 27.1% if FRAIL = 0 vs. 48.9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0.45 [0.26-0.77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/256043
https://dx.doi.org/urn:doi:10.3390/jcm11030672
url https://ddd.uab.cat/record/256043
https://dx.doi.org/urn:doi:10.3390/jcm11030672
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00037
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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