Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement

Grape and pomegranate are rich sources of phenolic compounds, and their derived products could be used as ingredients for the development of functional foods and dietary supplements. However, the profile of nonextractable or macromolecular phenolic compounds in these samples has not been evaluated....

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Authors: Pérez-Ramírez, Iza F., Reynoso-Camacho, Rosalía, Saura Calixto, Fulgencio D., Pérez-Jiménez, Jara
Format: article
Status:Versión aceptada para publicación
Publication Date:2018
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/170878
Online Access:http://hdl.handle.net/10261/170878
Access Level:Open access
Keyword:Ellagitannins
Pomaces
Phenolic compounds
Grape
Mass spectrometry
Pomegranate
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spelling Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplementPérez-Ramírez, Iza F.Reynoso-Camacho, RosalíaSaura Calixto, Fulgencio D.Pérez-Jiménez, JaraEllagitanninsPomacesPhenolic compoundsGrapeMass spectrometryPomegranateGrape and pomegranate are rich sources of phenolic compounds, and their derived products could be used as ingredients for the development of functional foods and dietary supplements. However, the profile of nonextractable or macromolecular phenolic compounds in these samples has not been evaluated. Here, we show a comprehensive characterization of extractable and nonextractable phenolic compounds of a grape/pomegranate pomace dietary supplement using high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight (HPLC-ESI-QTOF) and matrix-assisted laser desorption/ionization (MALDI)-TOF techniques. The main extractable phenolic compounds were several anthocyanins (principally malvidin 3-O-glucoside) as well as gallotannins and gallagyl derivatives; some phenolic compounds were reported in grape or pomegranate for the first time. Additionally, there was a high proportion of nonextractable phenolic compounds, including vanillic acid, and dihydroxybenzoic acid. Unidentified polymeric structures were detected by MALDI-TOF MS analysis. This study shows that mixed grape and pomegranate pomaces are a source of different classes of phenolic compounds including a high proportion of nonextractable phenolic compounds.Spanish Ministry of Science and Innovation (Grant No. AGL2014−55102-JIN). The authors are grateful for the CONACyT for the international scholarship granted to I.F.P.-R.Peer ReviewedAmerican Chemical SocietyMinisterio de Economía y Competitividad (España)Consejo Nacional de Ciencia y Tecnología (México)Ministerio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/170878reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014−55102-JINhttps://doi.org/10.1021/acs.jafc.7b05901Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1708782026-05-22T06:33:51Z
dc.title.none.fl_str_mv Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
title Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
spellingShingle Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
Pérez-Ramírez, Iza F.
Ellagitannins
Pomaces
Phenolic compounds
Grape
Mass spectrometry
Pomegranate
title_short Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
title_full Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
title_fullStr Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
title_full_unstemmed Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
title_sort Comprehensive characterization of extractable and nonextractable phenolic compounds by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight of a grape/pomegranate pomace dietary supplement
dc.creator.none.fl_str_mv Pérez-Ramírez, Iza F.
Reynoso-Camacho, Rosalía
Saura Calixto, Fulgencio D.
Pérez-Jiménez, Jara
author Pérez-Ramírez, Iza F.
author_facet Pérez-Ramírez, Iza F.
Reynoso-Camacho, Rosalía
Saura Calixto, Fulgencio D.
Pérez-Jiménez, Jara
author_role author
author2 Reynoso-Camacho, Rosalía
Saura Calixto, Fulgencio D.
Pérez-Jiménez, Jara
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Nacional de Ciencia y Tecnología (México)
Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ellagitannins
Pomaces
Phenolic compounds
Grape
Mass spectrometry
Pomegranate
topic Ellagitannins
Pomaces
Phenolic compounds
Grape
Mass spectrometry
Pomegranate
description Grape and pomegranate are rich sources of phenolic compounds, and their derived products could be used as ingredients for the development of functional foods and dietary supplements. However, the profile of nonextractable or macromolecular phenolic compounds in these samples has not been evaluated. Here, we show a comprehensive characterization of extractable and nonextractable phenolic compounds of a grape/pomegranate pomace dietary supplement using high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight (HPLC-ESI-QTOF) and matrix-assisted laser desorption/ionization (MALDI)-TOF techniques. The main extractable phenolic compounds were several anthocyanins (principally malvidin 3-O-glucoside) as well as gallotannins and gallagyl derivatives; some phenolic compounds were reported in grape or pomegranate for the first time. Additionally, there was a high proportion of nonextractable phenolic compounds, including vanillic acid, and dihydroxybenzoic acid. Unidentified polymeric structures were detected by MALDI-TOF MS analysis. This study shows that mixed grape and pomegranate pomaces are a source of different classes of phenolic compounds including a high proportion of nonextractable phenolic compounds.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/170878
url http://hdl.handle.net/10261/170878
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014−55102-JIN
https://doi.org/10.1021/acs.jafc.7b05901
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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