Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis

In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, alpha-sAPP, beta-sAPP, and A beta 38, A beta 40, A beta 42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the...

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Detalhes bibliográficos
Autores: Mañé Martínez, M. Alba, Olsson, Bob, Bau, Laura, Matas Martín, Elisabet, Cobo Calvo, Álvaro, Andreasson, Ulf, Blennow, Kaj, Romero Pinel, Lucía María, Martínez Yélamos, Sergio, Zetterberg, Henrik
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2016
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/128986
Acesso em linha:https://hdl.handle.net/2445/128986
Access Level:Acceso aberto
Palavra-chave:Esclerosi múltiple
Marcadors bioquímics
Multiple sclerosis
Biochemical markers
Descrição
Resumo:In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, alpha-sAPP, beta-sAPP, and A beta 38, A beta 40, A beta 42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.

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