High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011 June 2014 that had optimize...

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Detalhes bibliográficos
Autores: San Juan, Rafael, Viedma, Esther, Chaves, Fernando, Lalueza, Antonio, Fortún, Jesús, Loza, Elena, Pujol Rojo, Miquel, Ardanuy Tisaire, María Carmen, Morales, Isabel, Cueto, Marina de, Resino Foz, Elena, Morales Cartagena, Alejandra, Rico, Alicia, Romero, María P., Orellana, María Ángeles, López Medrano, Francisco, Fernández Ruiz, Mario, Aguado, José María
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126909
Acesso em linha:https://hdl.handle.net/2445/126909
Access Level:acceso abierto
Palavra-chave:Sang
Malalties bacterianes
Factors de risc en les malalties
Efecte dels medicaments sobre els microorganismes
Blood
Bacterial diseases
Risk factors in diseases
Effect of drugs on microorganisms
Descrição
Resumo:We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011 June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 mu g/mL and 0.5 mu g/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.

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