An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration
Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to incr...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/174532 |
| Acceso en línea: | https://hdl.handle.net/2445/174532 |
| Access Level: | acceso abierto |
| Palabra clave: | Neurosi obsessiva Neurobiologia Cervell Psiquiatria Obsessive-compulsive disorder Neurobiology Brain Psychiatry |
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An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaborationVan den Heuvel, Odile A.Boedhoe, Premika S. W.Bertolín Triquell, SaraBruin, Willem B.Francks, ClydeIvanov, IliyanJahanshad, NedaKong, Xiang-ZhenKwon, Ju SooO'Neill, JosephPaus, TomasPatel, YashPiras, FabrizioSchmaal, LianneSoriano Mas, CarlesSpalletta, GianfrancoWingen, Guido vanYun, Je YeonVriend, ChrisSimpson, Helen BlairVan Rooij, DaanHoexter, Marcelo Q.Hoogman, MartineBuitelaar, Jan K.Arnold, Paul D.Beucke, Jan C.Benedetti, FrancescoBollettini, IreneBose, AnushreeBrennan, Brian P.De Nadai, Alessandro S.FitzGerald, KateGruner, PatriciaGrünblatt, EdnaHirano, YoshiyukiHuyser, ChaimJames, AnthonyKoch, KathrinKvale, GerdLázaro García, LuisaLochner, ChristineMarsh, RachelMataix-Cols, DavidMorgado, PedroNakamae, TakashiNakao, TomohiroNarayanaswamy, Janardhanan C.Nurmi, Erika L.Pittenger, ChristopherReddy, Y. C. JanardhanSato, João R.Soreni, NoamStewart, S. EvelynTaylor, Stephan F.Tolin, DavidThomopoulos, Shopia I.Veltman, Dick J.Venkatasubramanian, GanesanWalitza, SusanneWang, ZhenThompson, Paul M.Stein, Dan J.ENIGMA-OCD working groupNeurosi obsessivaNeurobiologiaCervellPsiquiatriaObsessive-compulsive disorderNeurobiologyBrainPsychiatryNeuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA-OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA.Wiley2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/174532Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/hbm.24972Human Brain Mapping, 2022, vol. 43, num. 1, p. 23-26https://doi.org/10.1002/hbm.24972cc-by (c) Van den Heuvel, Odile A. et al., 2022http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1745322026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration |
| title |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration |
| spellingShingle |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration Van den Heuvel, Odile A. Neurosi obsessiva Neurobiologia Cervell Psiquiatria Obsessive-compulsive disorder Neurobiology Brain Psychiatry |
| title_short |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration |
| title_full |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration |
| title_fullStr |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration |
| title_full_unstemmed |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration |
| title_sort |
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration |
| dc.creator.none.fl_str_mv |
Van den Heuvel, Odile A. Boedhoe, Premika S. W. Bertolín Triquell, Sara Bruin, Willem B. Francks, Clyde Ivanov, Iliyan Jahanshad, Neda Kong, Xiang-Zhen Kwon, Ju Soo O'Neill, Joseph Paus, Tomas Patel, Yash Piras, Fabrizio Schmaal, Lianne Soriano Mas, Carles Spalletta, Gianfranco Wingen, Guido van Yun, Je Yeon Vriend, Chris Simpson, Helen Blair Van Rooij, Daan Hoexter, Marcelo Q. Hoogman, Martine Buitelaar, Jan K. Arnold, Paul D. Beucke, Jan C. Benedetti, Francesco Bollettini, Irene Bose, Anushree Brennan, Brian P. De Nadai, Alessandro S. FitzGerald, Kate Gruner, Patricia Grünblatt, Edna Hirano, Yoshiyuki Huyser, Chaim James, Anthony Koch, Kathrin Kvale, Gerd Lázaro García, Luisa Lochner, Christine Marsh, Rachel Mataix-Cols, David Morgado, Pedro Nakamae, Takashi Nakao, Tomohiro Narayanaswamy, Janardhanan C. Nurmi, Erika L. Pittenger, Christopher Reddy, Y. C. Janardhan Sato, João R. Soreni, Noam Stewart, S. Evelyn Taylor, Stephan F. Tolin, David Thomopoulos, Shopia I. Veltman, Dick J. Venkatasubramanian, Ganesan Walitza, Susanne Wang, Zhen Thompson, Paul M. Stein, Dan J. ENIGMA-OCD working group |
| author |
Van den Heuvel, Odile A. |
| author_facet |
Van den Heuvel, Odile A. Boedhoe, Premika S. W. Bertolín Triquell, Sara Bruin, Willem B. Francks, Clyde Ivanov, Iliyan Jahanshad, Neda Kong, Xiang-Zhen Kwon, Ju Soo O'Neill, Joseph Paus, Tomas Patel, Yash Piras, Fabrizio Schmaal, Lianne Soriano Mas, Carles Spalletta, Gianfranco Wingen, Guido van Yun, Je Yeon Vriend, Chris Simpson, Helen Blair Van Rooij, Daan Hoexter, Marcelo Q. Hoogman, Martine Buitelaar, Jan K. Arnold, Paul D. Beucke, Jan C. Benedetti, Francesco Bollettini, Irene Bose, Anushree Brennan, Brian P. De Nadai, Alessandro S. FitzGerald, Kate Gruner, Patricia Grünblatt, Edna Hirano, Yoshiyuki Huyser, Chaim James, Anthony Koch, Kathrin Kvale, Gerd Lázaro García, Luisa Lochner, Christine Marsh, Rachel Mataix-Cols, David Morgado, Pedro Nakamae, Takashi Nakao, Tomohiro Narayanaswamy, Janardhanan C. Nurmi, Erika L. Pittenger, Christopher Reddy, Y. C. Janardhan Sato, João R. Soreni, Noam Stewart, S. Evelyn Taylor, Stephan F. Tolin, David Thomopoulos, Shopia I. Veltman, Dick J. Venkatasubramanian, Ganesan Walitza, Susanne Wang, Zhen Thompson, Paul M. Stein, Dan J. ENIGMA-OCD working group |
| author_role |
author |
| author2 |
Boedhoe, Premika S. W. Bertolín Triquell, Sara Bruin, Willem B. Francks, Clyde Ivanov, Iliyan Jahanshad, Neda Kong, Xiang-Zhen Kwon, Ju Soo O'Neill, Joseph Paus, Tomas Patel, Yash Piras, Fabrizio Schmaal, Lianne Soriano Mas, Carles Spalletta, Gianfranco Wingen, Guido van Yun, Je Yeon Vriend, Chris Simpson, Helen Blair Van Rooij, Daan Hoexter, Marcelo Q. Hoogman, Martine Buitelaar, Jan K. Arnold, Paul D. Beucke, Jan C. Benedetti, Francesco Bollettini, Irene Bose, Anushree Brennan, Brian P. De Nadai, Alessandro S. FitzGerald, Kate Gruner, Patricia Grünblatt, Edna Hirano, Yoshiyuki Huyser, Chaim James, Anthony Koch, Kathrin Kvale, Gerd Lázaro García, Luisa Lochner, Christine Marsh, Rachel Mataix-Cols, David Morgado, Pedro Nakamae, Takashi Nakao, Tomohiro Narayanaswamy, Janardhanan C. Nurmi, Erika L. Pittenger, Christopher Reddy, Y. C. Janardhan Sato, João R. Soreni, Noam Stewart, S. Evelyn Taylor, Stephan F. Tolin, David Thomopoulos, Shopia I. Veltman, Dick J. Venkatasubramanian, Ganesan Walitza, Susanne Wang, Zhen Thompson, Paul M. Stein, Dan J. ENIGMA-OCD working group |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Neurosi obsessiva Neurobiologia Cervell Psiquiatria Obsessive-compulsive disorder Neurobiology Brain Psychiatry |
| topic |
Neurosi obsessiva Neurobiologia Cervell Psiquiatria Obsessive-compulsive disorder Neurobiology Brain Psychiatry |
| description |
Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA-OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/174532 |
| url |
https://hdl.handle.net/2445/174532 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1002/hbm.24972 Human Brain Mapping, 2022, vol. 43, num. 1, p. 23-26 https://doi.org/10.1002/hbm.24972 |
| dc.rights.none.fl_str_mv |
cc-by (c) Van den Heuvel, Odile A. et al., 2022 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
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cc-by (c) Van den Heuvel, Odile A. et al., 2022 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15,301629 |