Understanding blood oxygenation in a microfluidic meander double side membrane contactor

Lung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has b...

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Autores: Malankowska, M., Julian, I., Pellejero, I., Rho, H.S., Schlautmann, S., Tiggelaar, R.M., Pina, M.P., Gardeniers, H.J.G.E., Mallada, R.
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2019
País:España
Recursos:Universidad de Zaragoza
Repositório:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:78022
Acesso em linha:http://zaguan.unizar.es/record/78022
Access Level:Acceso aberto
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spelling Understanding blood oxygenation in a microfluidic meander double side membrane contactorMalankowska, M.Julian, I.Pellejero, I.Rho, H.S.Schlautmann, S.Tiggelaar, R.M.Pina, M.P.Gardeniers, H.J.G.E.Mallada, R.Lung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has been selected as reference model to investigate the oxygenation process. The design criteria for the fabricated devices has been to maximize the oxygen saturation level while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. A mathematical model for the oxygen transfer has been developed and validated by the experimental study. The obtained results demonstrate that blood was successfully oxygenated up to approximately 98% of O2 saturation and that the oxygen transfer rate at 1 mL/min blood flow rate was approximately 92 mL/min·m2. Finally, a sensitivity analysis of the key parameters, i.e. size of the channel, oxygen concentration in the gas phase and oxygen permeation properties of the membrane, is carried out to discuss the performance limits and to settle the guidelines for future developments.2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://zaguan.unizar.es/record/78022reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/DGA/EU-EACEAinfo:eu-repo/grantAgreement/ES/DGA/EU-EACEAinfo:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBNinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:780222026-05-29T13:59:51Z
dc.title.none.fl_str_mv Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title Understanding blood oxygenation in a microfluidic meander double side membrane contactor
spellingShingle Understanding blood oxygenation in a microfluidic meander double side membrane contactor
Malankowska, M.
title_short Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_full Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_fullStr Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_full_unstemmed Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_sort Understanding blood oxygenation in a microfluidic meander double side membrane contactor
dc.creator.none.fl_str_mv Malankowska, M.
Julian, I.
Pellejero, I.
Rho, H.S.
Schlautmann, S.
Tiggelaar, R.M.
Pina, M.P.
Gardeniers, H.J.G.E.
Mallada, R.
author Malankowska, M.
author_facet Malankowska, M.
Julian, I.
Pellejero, I.
Rho, H.S.
Schlautmann, S.
Tiggelaar, R.M.
Pina, M.P.
Gardeniers, H.J.G.E.
Mallada, R.
author_role author
author2 Julian, I.
Pellejero, I.
Rho, H.S.
Schlautmann, S.
Tiggelaar, R.M.
Pina, M.P.
Gardeniers, H.J.G.E.
Mallada, R.
author2_role author
author
author
author
author
author
author
author
description Lung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has been selected as reference model to investigate the oxygenation process. The design criteria for the fabricated devices has been to maximize the oxygen saturation level while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. A mathematical model for the oxygen transfer has been developed and validated by the experimental study. The obtained results demonstrate that blood was successfully oxygenated up to approximately 98% of O2 saturation and that the oxygen transfer rate at 1 mL/min blood flow rate was approximately 92 mL/min·m2. Finally, a sensitivity analysis of the key parameters, i.e. size of the channel, oxygen concentration in the gas phase and oxygen permeation properties of the membrane, is carried out to discuss the performance limits and to settle the guidelines for future developments.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/78022
url http://zaguan.unizar.es/record/78022
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/DGA/EU-EACEA
info:eu-repo/grantAgreement/ES/DGA/EU-EACEA
info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
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repository.mail.fl_str_mv
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