Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study

To assess the iron status among European adolescents through selected biochemical parameters in a cross-sectional study performed in 10 European cities. SUBJECTS/METHODS: Iron status was defined utilising biochemical indicators. Iron depletion was defined as low serum ferritin (SF<15 ¿g/l). Iron...

ver descrição completa

Detalhes bibliográficos
Autores: Ferrari, Marika, Díaz-Prieto, Ligia E., Nova, Esther, Gómez-Martínez, Sonia, Romeo, J., Veses, Ana M., Zapatera, Belén, Pozo Rubio, Tamara, Marcos, Ascensión
Tipo de documento: artigo
Data de publicação:2011
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/93804
Acesso em linha:http://hdl.handle.net/10261/93804
Access Level:Acceso aberto
Palavra-chave:Anaemia
Adolescent
Europe
Iron deficiency
id ES_1bb39fb02152c0c4f497cbe9be47a254
oai_identifier_str oai:digital.csic.es:10261/93804
network_acronym_str ES
network_name_str España
repository_id_str
spelling Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA StudyFerrari, MarikaDíaz-Prieto, Ligia E.Nova, EstherGómez-Martínez, SoniaRomeo, J.Veses, Ana M.Zapatera, BelénPozo Rubio, TamaraMarcos, AscensiónAnaemiaAdolescentEuropeIron deficiencyTo assess the iron status among European adolescents through selected biochemical parameters in a cross-sectional study performed in 10 European cities. SUBJECTS/METHODS: Iron status was defined utilising biochemical indicators. Iron depletion was defined as low serum ferritin (SF<15 ¿g/l). Iron deficiency (ID) was defined as high-soluble transferrin receptor (sTfR>8.5 mg/l) plus iron depletion. Iron deficiency anaemia (IDA) was defined as ID with haemoglobin (Hb) below the WHO cutoff for age and sex: 12.0 g/dl for girls and for boys aged 12.5-14.99 years and 13.0 g/dl for boys aged ¿15 years. Enzyme linked immunosorbent assay was used as analytical method for SF, sTfR and C-reactive protein (CRP). Subjects with indication of inflammation (CRP >5 mg/l) were excluded from the analyses. A total of 940 adolescents aged 12.5-17.49 years (438 boys and 502 girls) were involved. RESULTS: The percentage of iron depletion was 17.6%, significantly higher in girls (21.0%) compared with boys (13.8%). The overall percentage of ID and IDA was 4.7 and 1.3%, respectively, with no significant differences between boys and girls. A correlation was observed between log (SF) and Hb (r = 0.36, P < 0.01), and between log (sTfR) and mean corpuscular haemoglobin (r = -0.30, P < 0.01). Iron body stores were estimated on the basis of log (sTfR/SF). A higher percentage of negative values of body iron was recorded in girls (16.5%) with respect to boys (8.3%), and body iron values tended to increase with age in boys, whereas the values remained stable in girls. CONCLUSIONS: To ensure adequate iron stores, specific attention should be given to girls at European level to ensure that their dietary intake of iron is adequate.The HELENA Study was supported financially by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034).Peer reviewedPeer ReviewedNature Publishing GroupConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2014201420112014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/93804reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1038/ejcn.2010.279Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/938042026-05-22T06:33:51Z
dc.title.none.fl_str_mv Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
title Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
spellingShingle Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
Ferrari, Marika
Anaemia
Adolescent
Europe
Iron deficiency
title_short Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
title_full Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
title_fullStr Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
title_full_unstemmed Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
title_sort Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA Study
dc.creator.none.fl_str_mv Ferrari, Marika
Díaz-Prieto, Ligia E.
Nova, Esther
Gómez-Martínez, Sonia
Romeo, J.
Veses, Ana M.
Zapatera, Belén
Pozo Rubio, Tamara
Marcos, Ascensión
author Ferrari, Marika
author_facet Ferrari, Marika
Díaz-Prieto, Ligia E.
Nova, Esther
Gómez-Martínez, Sonia
Romeo, J.
Veses, Ana M.
Zapatera, Belén
Pozo Rubio, Tamara
Marcos, Ascensión
author_role author
author2 Díaz-Prieto, Ligia E.
Nova, Esther
Gómez-Martínez, Sonia
Romeo, J.
Veses, Ana M.
Zapatera, Belén
Pozo Rubio, Tamara
Marcos, Ascensión
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Anaemia
Adolescent
Europe
Iron deficiency
topic Anaemia
Adolescent
Europe
Iron deficiency
description To assess the iron status among European adolescents through selected biochemical parameters in a cross-sectional study performed in 10 European cities. SUBJECTS/METHODS: Iron status was defined utilising biochemical indicators. Iron depletion was defined as low serum ferritin (SF<15 ¿g/l). Iron deficiency (ID) was defined as high-soluble transferrin receptor (sTfR>8.5 mg/l) plus iron depletion. Iron deficiency anaemia (IDA) was defined as ID with haemoglobin (Hb) below the WHO cutoff for age and sex: 12.0 g/dl for girls and for boys aged 12.5-14.99 years and 13.0 g/dl for boys aged ¿15 years. Enzyme linked immunosorbent assay was used as analytical method for SF, sTfR and C-reactive protein (CRP). Subjects with indication of inflammation (CRP >5 mg/l) were excluded from the analyses. A total of 940 adolescents aged 12.5-17.49 years (438 boys and 502 girls) were involved. RESULTS: The percentage of iron depletion was 17.6%, significantly higher in girls (21.0%) compared with boys (13.8%). The overall percentage of ID and IDA was 4.7 and 1.3%, respectively, with no significant differences between boys and girls. A correlation was observed between log (SF) and Hb (r = 0.36, P < 0.01), and between log (sTfR) and mean corpuscular haemoglobin (r = -0.30, P < 0.01). Iron body stores were estimated on the basis of log (sTfR/SF). A higher percentage of negative values of body iron was recorded in girls (16.5%) with respect to boys (8.3%), and body iron values tended to increase with age in boys, whereas the values remained stable in girls. CONCLUSIONS: To ensure adequate iron stores, specific attention should be given to girls at European level to ensure that their dietary intake of iron is adequate.
publishDate 2011
dc.date.none.fl_str_mv 2011
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/93804
url http://hdl.handle.net/10261/93804
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1038/ejcn.2010.279
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404180956839936
score 15,228081

Registros relacionados